Detailed information NTG0142764

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: FCFHV36_RS00260
• Genome accession: NZ_CP011147
• Coordinates: 58489..59838 (-)
• Length: 449 a.a.
• NCBI ID: WP_000815646.1
• Uniprot ID: Q9XB96
• Organism: Staphylococcus aureus strain FCFHV36
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	38511..59838	58489..59838	within	0

Gene organization within MGE regions

Location: 38511..59838

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FCFHV36_RS00160 (FCFHV36_0029)	mecA	38511..40520 (-)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
FCFHV36_RS00165 (FCFHV36_0030)	mecR1	40617..42374 (+)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
FCFHV36_RS00170 (FCFHV36_0031)	mecI	42374..42745 (+)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
FCFHV36_RS16175	psm-mec	42830..42898 (-)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
FCFHV36_RS00175 (FCFHV36_0032)	-	43232..44362 (+)	1131	WP_010922808.1	ROK family transcriptional regulator	-
FCFHV36_RS00185 (FCFHV36_0034)	cstB	44476..45810 (-)	1335	Protein_34	persulfide dioxygenase-sulfurtransferase CstB	-
FCFHV36_RS00190 (FCFHV36_0035)	-	45843..46907 (-)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
FCFHV36_RS00195 (FCFHV36_0036)	cstR	47043..47303 (+)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
FCFHV36_RS00200 (FCFHV36_0037)	-	47303..47941 (+)	639	Protein_37	sulfite exporter TauE/SafE family protein	-
FCFHV36_RS00205 (FCFHV36_0038)	-	48286..48948 (-)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
FCFHV36_RS16600	-	49340..49396 (+)	57	WP_176746567.1	erythromycin resistance leader peptide	-
FCFHV36_RS00210 (FCFHV36_0039)	erm(A)	49444..50175 (+)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
FCFHV36_RS00215 (FCFHV36_0040)	-	50301..51083 (-)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
FCFHV36_RS00220 (FCFHV36_0041)	-	51234..51611 (-)	378	WP_000361059.1	DUF6262 family protein	-
FCFHV36_RS00225 (FCFHV36_0042)	-	51618..53510 (-)	1893	WP_001557544.1	site-specific integrase	-
FCFHV36_RS00230 (FCFHV36_0043)	-	53507..54592 (-)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
FCFHV36_RS00235 (FCFHV36_0044)	-	54711..55028 (-)	318	WP_000659050.1	JAB domain-containing protein	-
FCFHV36_RS00240 (FCFHV36_0045)	-	55049..55555 (-)	507	WP_001092169.1	DUF1643 domain-containing protein	-
FCFHV36_RS00245 (FCFHV36_0046)	-	55573..55884 (-)	312	WP_000700853.1	DUF960 family protein	-
FCFHV36_RS00250 (FCFHV36_0048)	-	55971..56321 (-)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
FCFHV36_RS00255 (FCFHV36_0049)	ccrB	56839..58467 (-)	1629	WP_001186602.1	cassette chromosome recombinase CcrB	Machinery gene
FCFHV36_RS00260 (FCFHV36_0050)	ccrA	58489..59838 (-)	1350	WP_000815646.1	cassette chromosome recombinase CcrA	Machinery gene

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52607.20 Da
• Isoelectric Point: 9.9585

>NTDB_id=142764 FCFHV36_RS00260 WP_000815646.1 58489..59838(-) (ccrA) [Staphylococcus aureus strain FCFHV36]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=142764 FCFHV36_RS00260 WP_000815646.1 58489..59838(-) (ccrA) [Staphylococcus aureus strain FCFHV36]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9XB96

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	100	100	1
ccrA	Staphylococcus aureus COL	74.833	100	0.748