Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | VT08_RS05640 | Genome accession | NZ_CP011069 |
| Coordinates | 1135890..1137695 (-) | Length | 601 a.a. |
| NCBI ID | WP_011054652.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain STAB09014 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1115638..1162694 | 1135890..1137695 | within | 0 |
Gene organization within MGE regions
Location: 1115638..1162694
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VT08_RS05545 (VT08_05570) | - | 1115676..1116950 (-) | 1275 | WP_011284930.1 | polysaccharide deacetylase family protein | - |
| VT08_RS05550 (VT08_05575) | - | 1117045..1118472 (-) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| VT08_RS05555 (VT08_05580) | ptsP | 1118657..1120390 (-) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| VT08_RS05560 (VT08_05585) | - | 1120395..1120658 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| VT08_RS05565 (VT08_05590) | - | 1121051..1121269 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| VT08_RS05570 (VT08_05595) | nrdE | 1121289..1123448 (+) | 2160 | WP_002993430.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| VT08_RS05575 (VT08_05600) | nrdF | 1123781..1124740 (+) | 960 | WP_011017933.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| VT08_RS05580 (VT08_05605) | - | 1124802..1126028 (+) | 1227 | WP_021340858.1 | chloride channel protein | - |
| VT08_RS09645 | - | 1126124..1127280 (+) | 1157 | Protein_1077 | IS3 family transposase | - |
| VT08_RS05605 (VT08_05630) | - | 1127374..1128069 (-) | 696 | WP_002989227.1 | CPBP family intramembrane glutamic endopeptidase | - |
| VT08_RS05610 (VT08_05635) | - | 1128088..1128849 (-) | 762 | WP_002995753.1 | DUF3169 family protein | - |
| VT08_RS05615 (VT08_05640) | - | 1128846..1129061 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| VT08_RS05620 (VT08_05645) | alaS | 1129422..1132040 (-) | 2619 | WP_011284933.1 | alanine--tRNA ligase | - |
| VT08_RS05625 (VT08_05650) | prsA | 1132427..1133482 (-) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| VT08_RS05630 (VT08_05655) | - | 1133545..1134252 (-) | 708 | WP_011284934.1 | O-methyltransferase | - |
| VT08_RS05635 (VT08_05660) | - | 1134318..1135514 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| VT08_RS05640 (VT08_05665) | pepF | 1135890..1137695 (-) | 1806 | WP_011054652.1 | oligoendopeptidase F | Regulator |
| VT08_RS05645 (VT08_05670) | - | 1137708..1138670 (-) | 963 | WP_002995771.1 | competence protein CoiA | - |
| VT08_RS05650 (VT08_05675) | - | 1138965..1139681 (-) | 717 | WP_002989197.1 | pseudouridine synthase | - |
| VT08_RS05655 (VT08_05680) | nagB | 1139800..1140504 (-) | 705 | WP_021340997.1 | glucosamine-6-phosphate deaminase | - |
| VT08_RS05660 (VT08_05685) | queA | 1140706..1141734 (+) | 1029 | WP_011284937.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| VT08_RS05665 (VT08_05690) | - | 1141741..1142961 (+) | 1221 | WP_002989189.1 | DUF3114 domain-containing protein | - |
| VT08_RS05670 (VT08_05695) | - | 1143075..1143665 (-) | 591 | WP_002989185.1 | serine hydrolase | - |
| VT08_RS05675 (VT08_05700) | - | 1143662..1143910 (-) | 249 | WP_002989183.1 | serine hydrolase | - |
| VT08_RS09650 (VT08_05705) | - | 1143966..1144121 (-) | 156 | WP_002989180.1 | hypothetical protein | - |
| VT08_RS05680 (VT08_05710) | sodA | 1144288..1144893 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| VT08_RS05685 (VT08_05715) | holA | 1144990..1146030 (-) | 1041 | WP_002989176.1 | DNA polymerase III subunit delta | - |
| VT08_RS05690 (VT08_05720) | - | 1146101..1148343 (-) | 2243 | Protein_1096 | DNA internalization-related competence protein ComEC/Rec2 | - |
| VT08_RS05695 (VT08_05725) | - | 1148324..1148986 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| VT08_RS05700 (VT08_05730) | - | 1149186..1149926 (-) | 741 | WP_065244899.1 | lysophospholipid acyltransferase family protein | - |
| VT08_RS05705 (VT08_05735) | - | 1150044..1150820 (+) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| VT08_RS05710 (VT08_05740) | - | 1150810..1151088 (+) | 279 | WP_011017953.1 | GIY-YIG nuclease family protein | - |
| VT08_RS05715 (VT08_05745) | - | 1151112..1153112 (-) | 2001 | WP_011284942.1 | potassium transporter Kup | - |
| VT08_RS05720 (VT08_05750) | - | 1153239..1154858 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| VT08_RS05725 (VT08_05755) | - | 1155165..1156709 (-) | 1545 | WP_011284943.1 | peptide chain release factor 3 | - |
| VT08_RS05730 (VT08_05760) | - | 1156957..1157652 (-) | 696 | WP_011017956.1 | TIGR02206 family membrane protein | - |
| VT08_RS05735 (VT08_05765) | - | 1157732..1159123 (-) | 1392 | WP_010922441.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| VT08_RS05740 (VT08_05770) | - | 1159322..1160368 (-) | 1047 | WP_002989146.1 | D-alanine--D-alanine ligase | - |
| VT08_RS05745 (VT08_05775) | recR | 1160469..1161065 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| VT08_RS09985 (VT08_05780) | - | 1161112..1161303 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| VT08_RS05755 (VT08_05785) | - | 1161863..1162642 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69341.19 Da Isoelectric Point: 4.7093
>NTDB_id=141989 VT08_RS05640 WP_011054652.1 1135890..1137695(-) (pepF) [Streptococcus pyogenes strain STAB09014]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=141989 VT08_RS05640 WP_011054652.1 1135890..1137695(-) (pepF) [Streptococcus pyogenes strain STAB09014]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.215 |
100 |
0.712 |