Detailed information
Bioinformatically predicted
Overview
| Name | sepM | Type | Regulator |
| Locus tag | MNA02_RS07815 | Genome accession | NZ_CP010999 |
| Coordinates | 1498053..1499129 (-) | Length | 358 a.a. |
| NCBI ID | WP_011681549.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus strain MN-BM-A02 | ||
| Function | processing of CSP (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1483306..1556103 | 1498053..1499129 | within | 0 |
Gene organization within MGE regions
Location: 1483306..1556103
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNA02_RS07750 (MNA02_1592) | - | 1484197..1484748 (-) | 552 | WP_002946999.1 | cysteine hydrolase family protein | - |
| MNA02_RS07755 (MNA02_1593) | codY | 1484811..1485596 (-) | 786 | WP_002951720.1 | GTP-sensing pleiotropic transcriptional regulator CodY | - |
| MNA02_RS07760 (MNA02_1594) | - | 1485856..1487070 (-) | 1215 | WP_002951721.1 | pyridoxal phosphate-dependent aminotransferase | - |
| MNA02_RS07765 (MNA02_1595) | - | 1487425..1487877 (+) | 453 | WP_002946987.1 | universal stress protein | - |
| MNA02_RS10485 | - | 1488057..1488628 (+) | 572 | Protein_1473 | IS30 family transposase | - |
| MNA02_RS11310 (MNA02_1597) | - | 1488700..1488873 (-) | 174 | WP_011681546.1 | hypothetical protein | - |
| MNA02_RS07775 (MNA02_1598) | - | 1488934..1489308 (-) | 375 | WP_011681547.1 | membrane protein | - |
| MNA02_RS07780 (MNA02_1599) | pflA | 1489520..1490320 (-) | 801 | WP_002946980.1 | pyruvate formate-lyase-activating protein | - |
| MNA02_RS10975 | - | 1490508..1490618 (-) | 111 | WP_014621906.1 | LPXTG cell wall anchor domain-containing protein | - |
| MNA02_RS07785 (MNA02_1600) | - | 1491316..1492647 (-) | 1332 | WP_024703987.1 | hemolysin family protein | - |
| MNA02_RS07790 (MNA02_1601) | - | 1492761..1493543 (+) | 783 | WP_024703988.1 | ABC transporter ATP-binding protein | - |
| MNA02_RS07795 (MNA02_1602) | - | 1494165..1496231 (-) | 2067 | WP_011681548.1 | cation:proton antiporter | - |
| MNA02_RS07800 (MNA02_1603) | - | 1496240..1496482 (-) | 243 | WP_011226461.1 | hypothetical protein | - |
| MNA02_RS07805 (MNA02_1604) | - | 1496479..1497027 (-) | 549 | WP_011226462.1 | tRNA (mnm(5)s(2)U34)-methyltransferase | - |
| MNA02_RS07810 (MNA02_1605) | - | 1497024..1497968 (-) | 945 | WP_011226463.1 | TIGR01212 family radical SAM protein | - |
| MNA02_RS07815 (MNA02_1606) | sepM | 1498053..1499129 (-) | 1077 | WP_011681549.1 | SepM family pheromone-processing serine protease | Regulator |
| MNA02_RS07820 (MNA02_1607) | coaD | 1499107..1499604 (-) | 498 | WP_011681550.1 | pantetheine-phosphate adenylyltransferase | - |
| MNA02_RS07825 (MNA02_1608) | rsmD | 1499638..1500237 (-) | 600 | Protein_1486 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| MNA02_RS07830 (MNA02_1609) | trxB | 1500328..1501281 (-) | 954 | WP_255136104.1 | thioredoxin-disulfide reductase | - |
| MNA02_RS07835 (MNA02_1610) | - | 1501314..1501538 (-) | 225 | WP_014621911.1 | DUF4059 family protein | - |
| MNA02_RS07840 (MNA02_1611) | - | 1501753..1502496 (-) | 744 | WP_014608652.1 | amino acid ABC transporter ATP-binding protein | - |
| MNA02_RS07845 (MNA02_1612) | - | 1502496..1503242 (-) | 747 | WP_100284797.1 | amino acid ABC transporter permease | - |
| MNA02_RS07850 (MNA02_1613) | - | 1503630..1504460 (-) | 831 | WP_014608653.1 | transporter substrate-binding domain-containing protein | - |
| MNA02_RS07855 (MNA02_1614) | - | 1504920..1505153 (-) | 234 | WP_002947030.1 | hypothetical protein | - |
| MNA02_RS07860 (MNA02_1615) | dinB | 1505451..1506554 (-) | 1104 | WP_014608654.1 | DNA polymerase IV | - |
| MNA02_RS07865 (MNA02_1616) | pflB | 1506833..1509142 (+) | 2310 | WP_011226473.1 | formate C-acetyltransferase | - |
| MNA02_RS07870 (MNA02_1617) | - | 1509409..1510191 (+) | 783 | WP_011681555.1 | carbonic anhydrase | - |
| MNA02_RS07875 (MNA02_1618) | - | 1510242..1510694 (+) | 453 | WP_014608655.1 | GNAT family N-acetyltransferase | - |
| MNA02_RS07880 (MNA02_1619) | - | 1511045..1511350 (-) | 306 | WP_014621914.1 | restriction endonuclease subunit S | - |
| MNA02_RS12040 (MNA02_1620) | mobV | 1511375..1511883 (-) | 509 | Protein_1498 | MobV family relaxase | - |
| MNA02_RS07895 (MNA02_1621) | - | 1512328..1513083 (-) | 756 | WP_011681558.1 | ABC transporter permease | - |
| MNA02_RS07900 (MNA02_1622) | - | 1513080..1513730 (-) | 651 | WP_024703990.1 | ATP-binding cassette domain-containing protein | - |
| MNA02_RS07905 (MNA02_1624) | - | 1513933..1514889 (-) | 957 | WP_024703991.1 | serine hydrolase domain-containing protein | - |
| MNA02_RS07910 (MNA02_1625) | - | 1514889..1515644 (-) | 756 | WP_011681560.1 | CppA family protein | - |
| MNA02_RS07915 (MNA02_1626) | - | 1515926..1516288 (+) | 363 | WP_014608659.1 | CPBP family intramembrane glutamic endopeptidase | - |
| MNA02_RS07920 (MNA02_1627) | gla | 1516375..1517238 (-) | 864 | WP_002951781.1 | aquaglyceroporin Gla | - |
| MNA02_RS07925 (MNA02_1628) | - | 1517359..1519626 (+) | 2268 | WP_011681561.1 | Xaa-Pro dipeptidyl-peptidase | - |
| MNA02_RS07930 | - | 1519706..1520086 (-) | 381 | WP_002951783.1 | hypothetical protein | - |
| MNA02_RS10870 | - | 1520211..1520474 (-) | 264 | WP_002945924.1 | hypothetical protein | - |
| MNA02_RS07935 (MNA02_1630) | - | 1520796..1521092 (-) | 297 | WP_004197070.1 | bacteriocin immunity protein | - |
| MNA02_RS07940 (MNA02_1631) | - | 1521257..1521463 (-) | 207 | WP_011681562.1 | hypothetical protein | - |
| MNA02_RS07945 (MNA02_1632) | - | 1521494..1522186 (-) | 693 | WP_224103184.1 | thioredoxin family protein | - |
| MNA02_RS10505 | - | 1522377..1523947 (+) | 1571 | WP_106693466.1 | IS3-like element ISSth1b family transposase | - |
| MNA02_RS07960 (MNA02_1635) | - | 1524093..1524347 (-) | 255 | WP_014608660.1 | Blp family class II bacteriocin | - |
| MNA02_RS12045 | - | 1524598..1524999 (-) | 402 | WP_024703992.1 | hypothetical protein | - |
| MNA02_RS07980 (MNA02_1637) | - | 1526004..1526234 (-) | 231 | WP_014608662.1 | bacteriocin class II family protein | - |
| MNA02_RS07985 (MNA02_1638) | - | 1526590..1526790 (-) | 201 | WP_011681569.1 | hypothetical protein | - |
| MNA02_RS07990 (MNA02_1639) | - | 1526809..1526985 (-) | 177 | WP_011681570.1 | Blp family class II bacteriocin | - |
| MNA02_RS07995 (MNA02_1640) | - | 1527239..1527970 (+) | 732 | WP_002948869.1 | LytR/AlgR family response regulator transcription factor | - |
| MNA02_RS11765 | - | 1528507..1529310 (+) | 804 | WP_224107502.1 | ATP-binding protein | - |
| MNA02_RS08005 (MNA02_1642) | - | 1529328..1529489 (-) | 162 | WP_011681573.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| MNA02_RS08010 (MNA02_1643) | - | 1529504..1530871 (-) | 1368 | WP_011681574.1 | bacteriocin secretion accessory protein | - |
| MNA02_RS08015 (MNA02_1645) | - | 1530887..1533039 (-) | 2153 | Protein_1521 | peptide cleavage/export ABC transporter | - |
| MNA02_RS08020 (MNA02_1647) | - | 1534053..1535798 (-) | 1746 | WP_024703994.1 | ABC transporter ATP-binding protein | - |
| MNA02_RS08025 (MNA02_1648) | - | 1535791..1537548 (-) | 1758 | WP_024703995.1 | ABC transporter ATP-binding protein | - |
| MNA02_RS11770 (MNA02_1649) | - | 1537736..1537942 (-) | 207 | WP_002948879.1 | hypothetical protein | - |
| MNA02_RS08035 (MNA02_1650) | - | 1538147..1538674 (-) | 528 | WP_011226503.1 | VanZ family protein | - |
| MNA02_RS08040 (MNA02_1651) | rlmN | 1538676..1539845 (-) | 1170 | WP_011226504.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| MNA02_RS08045 (MNA02_1652) | - | 1539849..1540571 (-) | 723 | WP_024703996.1 | YutD family protein | - |
| MNA02_RS08050 (MNA02_1653) | - | 1540626..1541981 (-) | 1356 | WP_002948886.1 | bifunctional metallophosphatase/5'-nucleotidase | - |
| MNA02_RS08055 (MNA02_1655) | - | 1542829..1544172 (-) | 1344 | WP_014608670.1 | DEAD/DEAH box helicase | - |
| MNA02_RS08060 (MNA02_1656) | mraY | 1544247..1545269 (-) | 1023 | WP_011227524.1 | phospho-N-acetylmuramoyl-pentapeptide- transferase | - |
| MNA02_RS08065 (MNA02_1657) | pbp2X | 1545271..1547538 (-) | 2268 | WP_011681584.1 | penicillin-binding protein PBP2X | - |
| MNA02_RS08070 (MNA02_1658) | ftsL | 1547542..1547862 (-) | 321 | WP_002948801.1 | cell division protein FtsL | - |
| MNA02_RS08075 (MNA02_1659) | rsmH | 1547865..1548815 (-) | 951 | WP_014621931.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH | - |
| MNA02_RS11775 (MNA02_1660) | - | 1548981..1549409 (-) | 429 | WP_011681585.1 | hypothetical protein | - |
| MNA02_RS11780 (MNA02_1661) | - | 1549375..1549590 (-) | 216 | WP_011681586.1 | hypothetical protein | - |
| MNA02_RS11785 (MNA02_1662) | - | 1549587..1549973 (-) | 387 | WP_011681587.1 | hypothetical protein | - |
| MNA02_RS10885 | - | 1550041..1550304 (+) | 264 | WP_164926319.1 | hypothetical protein | - |
| MNA02_RS08100 (MNA02_1665) | - | 1550610..1550966 (-) | 357 | WP_014621938.1 | DUF805 domain-containing protein | - |
| MNA02_RS08105 (MNA02_1666) | - | 1551186..1551476 (-) | 291 | WP_014621939.1 | hypothetical protein | - |
| MNA02_RS08110 (MNA02_1667) | - | 1551810..1553060 (-) | 1251 | WP_014621940.1 | glutamate-5-semialdehyde dehydrogenase | - |
| MNA02_RS08115 (MNA02_1668) | proB | 1553062..1553865 (-) | 804 | WP_014621941.1 | glutamate 5-kinase | - |
| MNA02_RS08120 (MNA02_1669) | - | 1553986..1555575 (-) | 1590 | WP_014608677.1 | ABC transporter permease | - |
Sequence
Protein
Download Length: 358 a.a. Molecular weight: 39172.02 Da Isoelectric Point: 9.3888
>NTDB_id=141240 MNA02_RS07815 WP_011681549.1 1498053..1499129(-) (sepM) [Streptococcus thermophilus strain MN-BM-A02]
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
Nucleotide
Download Length: 1077 bp
>NTDB_id=141240 MNA02_RS07815 WP_011681549.1 1498053..1499129(-) (sepM) [Streptococcus thermophilus strain MN-BM-A02]
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| sepM | Streptococcus mutans UA159 |
62.757 |
95.251 |
0.598 |