Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | FORC12_RS10480 | Genome accession | NZ_CP010998 |
| Coordinates | 2040377..2042005 (-) | Length | 542 a.a. |
| NCBI ID | WP_001186608.1 | Uniprot ID | - |
| Organism | Staphylococcus aureus strain FORC_012 isolate human sputum | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 2013666..2062078 | 2040377..2042005 | within | 0 |
| SCCmec | 2032053..2048547 | 2040377..2042005 | within | 0 |
Gene organization within MGE regions
Location: 2013666..2062078
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC12_RS10350 (FORC12_1869) | yycF | 2014124..2014825 (+) | 702 | WP_000101976.1 | response regulator YycF | - |
| FORC12_RS10355 (FORC12_1870) | walK | 2014838..2016664 (+) | 1827 | WP_000871607.1 | cell wall metabolism sensor histidine kinase WalK | - |
| FORC12_RS10360 (FORC12_1871) | yycH | 2016657..2017991 (+) | 1335 | WP_001060140.1 | two-component system activity regulator YycH | - |
| FORC12_RS10365 (FORC12_1872) | yycI | 2017992..2018780 (+) | 789 | WP_001104168.1 | two-component system regulatory protein YycI | - |
| FORC12_RS10370 (FORC12_1873) | - | 2019169..2019969 (+) | 801 | WP_000088649.1 | MBL fold metallo-hydrolase | - |
| FORC12_RS10375 (FORC12_1874) | adsA | 2020197..2022515 (+) | 2319 | WP_000645771.1 | LPXTG-anchored adenosine synthase AdsA | - |
| FORC12_RS10385 (FORC12_1876) | rlmH | 2022883..2023362 (+) | 480 | WP_000704775.1 | 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH | - |
| FORC12_RS10390 (FORC12_1877) | - | 2023684..2024940 (+) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| FORC12_RS10395 (FORC12_1878) | - | 2025355..2025594 (+) | 240 | WP_001282728.1 | hypothetical protein | - |
| FORC12_RS10400 (FORC12_1879) | - | 2025626..2026300 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| FORC12_RS10410 (FORC12_1881) | - | 2026391..2027374 (-) | 984 | Protein_1989 | protein rep | - |
| FORC12_RS10415 (FORC12_1882) | mobV | 2027619..2028881 (-) | 1263 | WP_029163598.1 | MobV family relaxase | - |
| FORC12_RS10420 (FORC12_1883) | bleO | 2029388..2029792 (-) | 405 | WP_001242578.1 | bleomycin binding protein | - |
| FORC12_RS10425 (FORC12_1884) | aadD1 | 2030009..2030779 (-) | 771 | WP_001795128.1 | aminoglycoside O-nucleotidyltransferase ANT(4')-Ia | - |
| FORC12_RS10430 (FORC12_1885) | - | 2030972..2031646 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| FORC12_RS10435 (FORC12_1886) | - | 2031702..2032007 (+) | 306 | Protein_1994 | MaoC/PaaZ C-terminal domain-containing protein | - |
| FORC12_RS10440 (FORC12_1887) | mecA | 2032053..2034062 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| FORC12_RS10445 (FORC12_1888) | - | 2034159..2035145 (+) | 987 | WP_001549960.1 | beta-lactam sensor/signal transducer MecR1 | - |
| FORC12_RS10450 | - | 2035117..2035377 (+) | 261 | WP_001549961.1 | type I restriction enzyme endonuclease domain-containing protein | - |
| FORC12_RS10455 (FORC12_1889) | - | 2035644..2036843 (+) | 1200 | WP_073392450.1 | IS110-like element ISSep2 family transposase | - |
| FORC12_RS10460 (FORC12_1890) | - | 2036940..2038535 (-) | 1596 | Protein_1999 | IS1182 family transposase | - |
| FORC12_RS10465 (FORC12_1891) | - | 2038587..2039093 (-) | 507 | WP_001092189.1 | DUF1643 domain-containing protein | - |
| FORC12_RS10470 (FORC12_1892) | - | 2039108..2039418 (-) | 311 | Protein_2001 | DUF960 family protein | - |
| FORC12_RS10475 (FORC12_1893) | - | 2039505..2039855 (-) | 351 | WP_000849672.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| FORC12_RS10480 (FORC12_1894) | ccrB | 2040377..2042005 (-) | 1629 | WP_001186608.1 | recombinase family protein | Machinery gene |
| FORC12_RS10485 (FORC12_1895) | ccrA | 2042027..2043376 (-) | 1350 | WP_061477632.1 | recombinase family protein | Machinery gene |
| FORC12_RS10490 (FORC12_1896) | - | 2043610..2045403 (-) | 1794 | WP_000079474.1 | DUF927 domain-containing protein | - |
| FORC12_RS10495 (FORC12_1897) | - | 2045403..2045699 (-) | 297 | WP_000273823.1 | single-stranded DNA-binding protein | - |
| FORC12_RS10500 (FORC12_1898) | - | 2045892..2046938 (-) | 1047 | WP_001042023.1 | hypothetical protein | - |
| FORC12_RS10505 (FORC12_1899) | - | 2047393..2048547 (+) | 1155 | WP_000912116.1 | ATP-binding protein | - |
| FORC12_RS10510 (FORC12_1900) | - | 2048577..2049377 (+) | 801 | WP_000749913.1 | abortive infection family protein | - |
| FORC12_RS10515 (FORC12_1901) | - | 2049560..2050495 (+) | 936 | WP_000251226.1 | dsDNA nuclease domain-containing protein | - |
| FORC12_RS10520 (FORC12_1902) | - | 2050488..2051096 (+) | 609 | WP_029163516.1 | hypothetical protein | - |
| FORC12_RS15315 (FORC12_1903) | - | 2051093..2052160 (+) | 1068 | WP_223286853.1 | hypothetical protein | - |
| FORC12_RS10530 (FORC12_1904) | - | 2052407..2053393 (-) | 987 | WP_000662022.1 | tRNA-dihydrouridine synthase | - |
| FORC12_RS10535 (FORC12_1905) | - | 2053702..2053905 (+) | 204 | WP_000398680.1 | DUF6007 family protein | - |
| FORC12_RS10540 (FORC12_1906) | - | 2053954..2054250 (+) | 297 | WP_000179888.1 | TfoX/Sxy family protein | - |
| FORC12_RS10545 (FORC12_1907) | - | 2054459..2055061 (+) | 603 | WP_000908959.1 | hypothetical protein | - |
| FORC12_RS10550 (FORC12_1908) | - | 2055353..2056267 (-) | 915 | WP_000814441.1 | alpha/beta hydrolase | - |
| FORC12_RS10555 (FORC12_1909) | - | 2056446..2057000 (+) | 555 | WP_020977952.1 | TetR/AcrR family transcriptional regulator C-terminal domain-containing protein | - |
| FORC12_RS10560 (FORC12_1910) | - | 2057230..2057967 (+) | 738 | WP_001792407.1 | methyltransferase domain-containing protein | - |
| FORC12_RS10565 (FORC12_1911) | - | 2058123..2058605 (+) | 483 | WP_000410569.1 | hypothetical protein | - |
| FORC12_RS10570 (FORC12_1912) | - | 2058811..2059797 (+) | 987 | WP_000710561.1 | phosphatidylinositol-specific phospholipase C | - |
| FORC12_RS10575 (FORC12_1913) | - | 2060018..2060788 (+) | 771 | WP_000977794.1 | tandem-type lipoprotein | - |
| FORC12_RS10580 (FORC12_1914) | - | 2060855..2061622 (+) | 768 | WP_000649985.1 | tandem-type lipoprotein | - |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62654.83 Da Isoelectric Point: 9.7970
>NTDB_id=141189 FORC12_RS10480 WP_001186608.1 2040377..2042005(-) (ccrB) [Staphylococcus aureus strain FORC_012 isolate human sputum]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRMLKDAKEGNIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFECYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKINNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKTLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRMLKDAKEGNIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFECYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKINNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKTLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
Nucleotide
Download Length: 1629 bp
>NTDB_id=141189 FORC12_RS10480 WP_001186608.1 2040377..2042005(-) (ccrB) [Staphylococcus aureus strain FORC_012 isolate human sputum]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTTTCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGATGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAGGTCAAAGATATATACGCTGATCGTGGTA
TTTCAGGTAAATCTATGAACAGACCTGAGCTCCAACGTATGTTGAAAGATGCAAAAGAAGGCAATATCGACTGTGTTATG
GTATACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTGTCAGAGCGTATGGAAGTCAATACTTCTTCTGGTAAACTCATGTTACAGATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAACGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTACCACTAGGTTATGACAAAATACCAGATAGTAAACACGAGCTAATGATTAACCAACATGAAGCTAATATTGTAAAATA
TATATTCGAGTGCTATGCCAAAGGACATGGCTATCGTAAAATTGCCAATGCATTGAATCACAAAGGATATGTCACTAAAA
AGGGGAAACCTTTCAGTATTAGTTCAATCACATACATCTTAGCTAACCCTTTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTGAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTTCATGGTAAAGGAACGA
ATCTGCTTACAGGCATTATCCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACAACGAATACACTTAAAGAT
GGGACCAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTAATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAAATAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGACTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATTAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTATTTT
TGCCCCAAACACTATATCTTACTATTTAG
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTTTCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGATGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAGGTCAAAGATATATACGCTGATCGTGGTA
TTTCAGGTAAATCTATGAACAGACCTGAGCTCCAACGTATGTTGAAAGATGCAAAAGAAGGCAATATCGACTGTGTTATG
GTATACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTGTCAGAGCGTATGGAAGTCAATACTTCTTCTGGTAAACTCATGTTACAGATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAACGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTACCACTAGGTTATGACAAAATACCAGATAGTAAACACGAGCTAATGATTAACCAACATGAAGCTAATATTGTAAAATA
TATATTCGAGTGCTATGCCAAAGGACATGGCTATCGTAAAATTGCCAATGCATTGAATCACAAAGGATATGTCACTAAAA
AGGGGAAACCTTTCAGTATTAGTTCAATCACATACATCTTAGCTAACCCTTTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTGAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTTCATGGTAAAGGAACGA
ATCTGCTTACAGGCATTATCCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACAACGAATACACTTAAAGAT
GGGACCAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTAATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAAATAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGACTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATTAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTATTTT
TGCCCCAAACACTATATCTTACTATTTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
98.893 |
100 |
0.989 |