Detailed information NTG0141185

Bioinformatically predicted

Overview

• Name: braS
• Type: Regulator
• Locus tag: FORC12_RS09815
• Genome accession: NZ_CP010998
• Coordinates: 1888255..1889142 (-)
• Length: 295 a.a.
• NCBI ID: WP_000143420.1
• Uniprot ID: A0A2S6DP21
• Organism: Staphylococcus aureus strain FORC_012 isolate human sputum
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1883255..1894142

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FORC12_RS09780	-	1883273..1883365 (+)	93	WP_010956583.1	hypothetical protein	-
FORC12_RS09785 (FORC12_1761)	-	1883473..1883970 (-)	498	WP_001065269.1	glutathione peroxidase	-
FORC12_RS09790	-	1883980..1884240 (-)	261	WP_001789910.1	hypothetical protein	-
FORC12_RS09795	-	1884622..1884735 (-)	114	Protein_1871	hypothetical protein	-
FORC12_RS09805 (FORC12_1762)	-	1885394..1887394 (-)	2001	WP_000776739.1	ABC transporter permease	-
FORC12_RS09810 (FORC12_1763)	-	1887391..1888146 (-)	756	WP_000923760.1	ABC transporter ATP-binding protein	-
FORC12_RS09815 (FORC12_1764)	braS	1888255..1889142 (-)	888	WP_000143420.1	nisin susceptibility-associated two-component system sensor histidine kinase NsaS	Regulator
FORC12_RS09820 (FORC12_1765)	braR	1889153..1889818 (-)	666	WP_000697879.1	nisin susceptibility-associated two-component system response regulator NsaR	Regulator
FORC12_RS09825 (FORC12_1766)	-	1889844..1890044 (-)	201	WP_000604727.1	hypothetical protein	-
FORC12_RS09835 (FORC12_1767)	-	1890242..1891666 (+)	1425	WP_000953762.1	alkaline phosphatase	-
FORC12_RS15140	-	1891736..1891846 (+)	111	WP_001791296.1	hypothetical protein	-
FORC12_RS09840 (FORC12_1768)	-	1891949..1892404 (-)	456	WP_000106185.1	MarR family winged helix-turn-helix transcriptional regulator	-
FORC12_RS09845 (FORC12_1769)	-	1892649..1893410 (-)	762	WP_000323447.1	alpha/beta hydrolase family protein	-

Sequence

Protein

• Length: 295 a.a.
• Molecular weight: 34045.32 Da
• Isoelectric Point: 5.8962

>NTDB_id=141185 FORC12_RS09815 WP_000143420.1 1888255..1889142(-) (braS) [Staphylococcus aureus strain FORC_012 isolate human sputum]
MTFLKSITQEIAIVIVIFALFGLMFYLYHLPLEAYLLALGVILLLLLIFIGIKYLSFVKTISQQQQIENLENALYQLKNE
QIEYKNDVESYFLTWVHQMKTPITAAQLLLERDEPNVVNRVRQEVIQIDNYTSLALSYLKLLNETSDISVTKISINNIIR
PIIMKYSIQFIDQKTKIHYEPCHHEVLTDVRWTSLMIEQLINNALKYARGKDIWIEFDEQSNQLYVKDNGIGISEADLPK
IFDKGYSGYNGQRQSNSSGIGLFIVKQISTHTNHPVSVVSKQNEGTTFTIQFPDE

Nucleotide

• Length: 888 bp

>NTDB_id=141185 FORC12_RS09815 WP_000143420.1 1888255..1889142(-) (braS) [Staphylococcus aureus strain FORC_012 isolate human sputum]
ATGACCTTTCTTAAAAGTATTACTCAGGAAATAGCAATAGTCATAGTTATTTTTGCTTTATTTGGCTTAATGTTTTACCT
GTATCATTTGCCATTAGAAGCATATTTACTAGCACTTGGCGTTATTTTATTATTATTACTCATATTCATAGGTATTAAAT
ATTTAAGTTTTGTAAAAACTATAAGCCAACAACAACAAATTGAAAACTTAGAAAATGCGTTGTATCAGCTTAAAAATGAA
CAAATTGAATATAAAAATGATGTAGAGAGCTACTTTTTAACATGGGTACATCAAATGAAAACACCCATTACTGCAGCACA
ACTGTTACTTGAAAGAGATGAGCCTAATGTTGTGAATCGTGTTCGTCAAGAGGTTATTCAAATTGATAACTATACAAGTT
TAGCACTTAGTTATTTAAAGTTATTAAATGAAACTTCTGATATTTCTGTCACTAAAATTTCGATTAATAATATCATTCGC
CCAATTATTATGAAATATTCAATACAGTTTATTGATCAAAAAACAAAAATCCATTATGAACCTTGTCATCACGAAGTATT
AACTGACGTTAGATGGACCTCTTTAATGATAGAACAATTAATAAATAATGCACTTAAGTATGCGAGAGGTAAAGATATAT
GGATTGAATTTGATGAGCAATCCAATCAATTATACGTAAAAGATAATGGTATCGGTATTAGTGAAGCGGACTTGCCTAAA
ATATTTGATAAGGGCTATTCAGGTTATAATGGCCAGCGCCAAAGTAACTCAAGTGGGATTGGTTTATTTATCGTAAAACA
AATTTCAACACACACAAACCATCCTGTTTCAGTCGTATCTAAACAAAATGAGGGTACAACATTTACGATTCAATTTCCAG
ATGAATAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (191-294)

3D structure

• AlphaFold DB: A0A2S6DP21

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
braS	Staphylococcus aureus N315	99.322	100	0.993