Detailed information    

experimental Experimentally validated

Overview

Name   comC   Type   Machinery gene
Locus tag   A4U84_RS02020 Genome accession   NZ_CP015099
Coordinates   461916..462446 (-) Length   176 a.a.
NCBI ID   WP_021119496.1    Uniprot ID   -
Organism   Glaesserella parasuis strain SC1401     
Function   type IV pilus biogenesis and function   
DNA binding and uptake

Function

The expression levels of candidate uptake components were significantly lower than in SC1401, respectively. These results revealed that the highly naturally competent strain SC1401 up-regulated most of the candidate natural competence-related regulons/components.


Genomic Context

Location: 456916..467446
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A4U84_RS01985 (A4U84_01985) trxA 457074..457388 (-) 315 WP_015940165.1 thioredoxin -
  A4U84_RS01990 (A4U84_01990) - 457685..458314 (-) 630 WP_015940164.1 LysE family transporter -
  A4U84_RS01995 (A4U84_01995) - 458316..458786 (-) 471 WP_021113432.1 phosphatidylglycerophosphatase A family protein -
  A4U84_RS02000 (A4U84_02000) thiL 458789..459757 (-) 969 WP_062923924.1 thiamine-phosphate kinase -
  A4U84_RS02005 (A4U84_02005) nusB 459766..460179 (-) 414 WP_021112072.1 transcription antitermination factor NusB -
  A4U84_RS02010 (A4U84_02010) comE 460258..461520 (-) 1263 WP_021113424.1 type IV pilus secretin PilQ Machinery gene
  A4U84_RS02015 (A4U84_02015) comD 461530..461871 (-) 342 WP_235629440.1 hypothetical protein Machinery gene
  A4U84_RS02020 (A4U84_02020) comC 461916..462446 (-) 531 WP_021119496.1 hypothetical protein Machinery gene
  A4U84_RS02025 (A4U84_02025) comB 462443..462964 (-) 522 WP_062923926.1 hypothetical protein Machinery gene
  A4U84_RS02030 (A4U84_02030) comA 462940..463617 (-) 678 WP_021113429.1 hypothetical protein Machinery gene
  A4U84_RS02035 (A4U84_02035) - 463771..466326 (+) 2556 WP_062923927.1 penicillin-binding protein 1A -
  A4U84_RS02040 (A4U84_02040) aroK 466556..467077 (+) 522 WP_015940157.1 shikimate kinase AroK -

Sequence

Protein


Download         Length: 176 a.a.        Molecular weight: 20850.32 Da        Isoelectric Point: 9.9672

>NTDB_id=1379 A4U84_RS02020 WP_021119496.1 461916..462446(-) (comC) [Glaesserella parasuis strain SC1401]
MKLSLAKYYLMPQHPLYRGLYYLNQNKIFILSGIFLLIMAFPIGNYLYLNQQIAQQQKQLTEFKQINEHKQQQLKLLQQR
YQLAQDKSELLTQINQQIQKILDKNSVEIDSIQWNMEERKIYLLISQSTQKVLNVIADLNQLTTVKFQEIHLTKKTKQKH
IQLNATLLFQADTGEP

Nucleotide


Download         Length: 531 bp        

>NTDB_id=1379 A4U84_RS02020 WP_021119496.1 461916..462446(-) (comC) [Glaesserella parasuis strain SC1401]
ATGAAATTGTCCTTAGCCAAGTATTATTTAATGCCACAACATCCATTATATCGTGGTTTATATTATTTAAACCAAAATAA
AATATTTATTCTATCGGGAATATTTTTGTTAATTATGGCATTTCCAATAGGAAATTATCTTTATCTTAATCAGCAAATAG
CTCAACAACAAAAACAGCTCACTGAATTTAAACAGATTAACGAACATAAACAGCAACAATTAAAATTATTACAACAACGT
TATCAACTTGCTCAAGATAAAAGTGAATTATTAACCCAAATAAATCAACAAATTCAAAAAATCTTGGATAAAAACAGCGT
AGAAATTGACAGTATTCAATGGAATATGGAAGAAAGAAAAATCTATTTATTAATCAGCCAATCTACGCAAAAGGTACTTA
ATGTGATTGCTGATCTTAATCAATTAACCACAGTTAAATTTCAGGAAATCCATTTAACTAAAAAAACAAAACAGAAACAT
ATTCAACTCAATGCCACTTTGCTTTTTCAAGCTGACACAGGAGAACCCTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value

References

[1] Ke Dai et al. (2018) Basic Characterization of Natural Transformation in a Highly Transformable Haemophilus parasuis Strain SC1401. Frontiers in Cellular And Infection Microbiology 8:32. [PMID: 29473023]