Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | SD89_RS06045 | Genome accession | NZ_CP010449 |
| Coordinates | 1230640..1232445 (-) | Length | 601 a.a. |
| NCBI ID | WP_002995768.1 | Uniprot ID | A0A660A6L4 |
| Organism | Streptococcus pyogenes strain NGAS322 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1210351..1257448 | 1230640..1232445 | within | 0 |
Gene organization within MGE regions
Location: 1210351..1257448
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SD89_RS05955 (SD89_05970) | - | 1210389..1211663 (-) | 1275 | WP_023079402.1 | polysaccharide deacetylase family protein | - |
| SD89_RS05960 (SD89_05975) | - | 1211758..1213185 (-) | 1428 | WP_053308453.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| SD89_RS05965 (SD89_05980) | ptsP | 1213370..1215103 (-) | 1734 | WP_020837320.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| SD89_RS05970 (SD89_05985) | - | 1215108..1215371 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| SD89_RS05975 (SD89_05990) | - | 1215764..1215982 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| SD89_RS05980 (SD89_05995) | nrdE | 1216002..1218161 (+) | 2160 | WP_002984018.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| SD89_RS05985 (SD89_06000) | nrdF | 1218494..1219453 (+) | 960 | WP_002987365.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| SD89_RS05990 (SD89_06005) | - | 1219515..1220741 (+) | 1227 | WP_391592263.1 | chloride channel protein | - |
| SD89_RS10150 | - | 1220879..1222029 (+) | 1151 | Protein_1145 | IS3 family transposase | - |
| SD89_RS06010 (SD89_06025) | - | 1222126..1222821 (-) | 696 | WP_053308455.1 | CPBP family intramembrane glutamic endopeptidase | - |
| SD89_RS06015 (SD89_06030) | - | 1222840..1223601 (-) | 762 | WP_053308456.1 | DUF3169 family protein | - |
| SD89_RS06020 (SD89_06035) | - | 1223598..1223813 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| SD89_RS06025 (SD89_06040) | alaS | 1224171..1226789 (-) | 2619 | WP_012560795.1 | alanine--tRNA ligase | - |
| SD89_RS06030 (SD89_06045) | prsA | 1227176..1228231 (-) | 1056 | WP_053308457.1 | peptidylprolyl isomerase PrsA | - |
| SD89_RS06035 (SD89_06050) | - | 1228294..1229001 (-) | 708 | WP_047235770.1 | O-methyltransferase | - |
| SD89_RS06040 (SD89_06055) | - | 1229067..1230263 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| SD89_RS06045 (SD89_06060) | pepF | 1230640..1232445 (-) | 1806 | WP_002995768.1 | oligoendopeptidase F | Regulator |
| SD89_RS06050 (SD89_06065) | - | 1232458..1233420 (-) | 963 | WP_002995771.1 | competence protein CoiA | - |
| SD89_RS06055 (SD89_06070) | - | 1233715..1234431 (-) | 717 | WP_002995774.1 | pseudouridine synthase | - |
| SD89_RS06060 (SD89_06075) | nagB | 1234550..1235254 (-) | 705 | WP_053308458.1 | glucosamine-6-phosphate deaminase | - |
| SD89_RS06065 (SD89_06080) | queA | 1235456..1236484 (+) | 1029 | WP_002983989.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| SD89_RS06070 (SD89_06085) | - | 1236491..1237711 (+) | 1221 | WP_053308459.1 | DUF3114 domain-containing protein | - |
| SD89_RS06075 (SD89_06090) | - | 1237825..1238415 (-) | 591 | WP_053308460.1 | serine hydrolase | - |
| SD89_RS10440 (SD89_06095) | - | 1238412..1238639 (-) | 228 | WP_226316535.1 | hypothetical protein | - |
| SD89_RS06085 (SD89_06100) | - | 1238640..1238873 (-) | 234 | WP_002983979.1 | hypothetical protein | - |
| SD89_RS06090 (SD89_06105) | sodA | 1239040..1239645 (-) | 606 | WP_032465084.1 | superoxide dismutase SodA | - |
| SD89_RS06095 (SD89_06110) | holA | 1239742..1240782 (-) | 1041 | WP_011888795.1 | DNA polymerase III subunit delta | - |
| SD89_RS06100 (SD89_06115) | - | 1240853..1243096 (-) | 2244 | WP_053308461.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| SD89_RS06105 (SD89_06120) | - | 1243077..1243739 (-) | 663 | WP_053308462.1 | ComEA family DNA-binding protein | - |
| SD89_RS06110 (SD89_06125) | - | 1243939..1244679 (-) | 741 | WP_053308463.1 | lysophospholipid acyltransferase family protein | - |
| SD89_RS06115 (SD89_06130) | - | 1244797..1245573 (+) | 777 | WP_080370170.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| SD89_RS06120 (SD89_06135) | - | 1245563..1245841 (+) | 279 | WP_002989164.1 | GIY-YIG nuclease family protein | - |
| SD89_RS06125 (SD89_06140) | - | 1245865..1247865 (-) | 2001 | WP_023612776.1 | potassium transporter Kup | - |
| SD89_RS06130 (SD89_06145) | - | 1247993..1249612 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| SD89_RS06135 (SD89_06150) | - | 1249919..1251463 (-) | 1545 | WP_002989155.1 | peptide chain release factor 3 | - |
| SD89_RS06140 (SD89_06155) | - | 1251711..1252406 (-) | 696 | WP_053308465.1 | TIGR02206 family membrane protein | - |
| SD89_RS06145 (SD89_06160) | - | 1252486..1253877 (-) | 1392 | WP_053308466.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| SD89_RS06150 (SD89_06165) | - | 1254076..1255122 (-) | 1047 | WP_002983941.1 | D-alanine--D-alanine ligase | - |
| SD89_RS06155 (SD89_06170) | recR | 1255223..1255819 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| SD89_RS10610 (SD89_06175) | - | 1255866..1256057 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| SD89_RS06165 (SD89_06180) | - | 1256617..1257396 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69394.45 Da Isoelectric Point: 4.8408
>NTDB_id=137338 SD89_RS06045 WP_002995768.1 1230640..1232445(-) (pepF) [Streptococcus pyogenes strain NGAS322]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=137338 SD89_RS06045 WP_002995768.1 1230640..1232445(-) (pepF) [Streptococcus pyogenes strain NGAS322]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGACGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGACGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
70.715 |
100 |
0.707 |