Detailed information NTG0137176

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: PGF_RS00045
• Genome accession: NZ_CP012889
• Coordinates: 7400..9979 (+)
• Length: 859 a.a.
• NCBI ID: WP_012457165.1
• Uniprot ID: B2RGN2
• Organism: Porphyromonas gingivalis 381
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 2400..14979

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PGF_RS00020 (PGF_00000040)	-	3108..3812 (+)	705	WP_012457161.1	NAD-dependent deacylase	-
PGF_RS00025 (PGF_00000050)	-	3887..5041 (-)	1155	WP_012457162.1	metallophosphoesterase	-
PGF_RS00030 (PGF_00000060)	-	5094..6473 (-)	1380	WP_012457163.1	MATE family efflux transporter	-
PGF_RS11980	-	6933..7013 (-)	81	WP_353558829.1	DUF1661 domain-containing protein	-
PGF_RS10905 (PGF_00000090)	-	6994..7380 (+)	387	WP_353558830.1	DUF1661 domain-containing protein	-
PGF_RS00045 (PGF_00000100)	clpC	7400..9979 (+)	2580	WP_012457165.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
PGF_RS00050 (PGF_00000110)	-	10119..13130 (+)	3012	WP_012457166.1	glycoside hydrolase family 3 N-terminal domain-containing protein	-
PGF_RS00055 (PGF_00000120)	-	13178..14206 (+)	1029	WP_012457167.1	pyridoxal phosphate-dependent aminotransferase	-

Sequence

Protein

• Length: 859 a.a.
• Molecular weight: 95472.01 Da
• Isoelectric Point: 4.7317

>NTDB_id=137176 PGF_RS00045 WP_012457165.1 7400..9979(+) (clpC) [Porphyromonas gingivalis 381]
MAYDFTQTFRNSLEYSYQEATRLGVVAVTQDMLVLGIIRDGDNGAIDIMRHYGINLYELKRLIELEAIAESLPASPEGLP
IFTPSAREAIDDATDICADMEDEAVSPVHLLLSILNSTQESLVQKIFMKQGIKYDTILSDYFGQRNPSEGKSPSEMEILD
GYQDNDFDDEEDESSPPSGNSGTGGGSGDAPEQNTGGGDTTTTTRSGGDTPALDTFGTDITAMAAAGKLDPVVGREQEIE
RVIQILSRRKKNNPVLIGEPGVGKSAIVEGLAERIVNRKVSRILFDKRIISLDLAQMVAGTKYRGQFEERLKAVLDELKK
NPQIILFIDEIHTIVGAGSAAGSMDTANMLKPALARGQVQCIGATTLDEYRKNIEKDGALERRFQKVPIAPSTAEETLTI
LQNIKEKYEDYHGVRYTDEAIKAAVELTDRYVSDRFFPDKAIDAMDEAGASVHITNVVAPKEIEILEAELASVRENKLSA
VKAQNYELAASFRDQERRTQQQIAEEKKKWEEQMSKHRETVDENVVAHVVALMTGVPAERLSTGEGERLRTMADDLKTKV
VGQDTAIEKMVRAIQRNRLGLRNEKKPIGSFLFLGPTGVGKTYLAKKLAEYLFEDENAMIRVDMSEYMEKFSVSRLVGAP
PGYVGYEEGGQLTERVRRKPYSVVLLDEIEKAHADVFNLLLQVMDEGQLTDSLGRRVNFKNTVIIITSNVGTRQLKDFGQ
GIGFRSEKDEEANKEHSRSVIQKALNKTFSPEFLNRLDDIILFDQLGKTEIRRMVDIELKAVLARIHRAGYDLVLTDEAK
DVIATKGYDLQYGARPLKRTLQNEVEDRLTDLILSGQIEKGQTLTLSARDGEIIVQEQA

Nucleotide

• Length: 2580 bp

>NTDB_id=137176 PGF_RS00045 WP_012457165.1 7400..9979(+) (clpC) [Porphyromonas gingivalis 381]
ATGGCATACGACTTTACACAAACATTCCGCAACAGCCTGGAGTACAGCTATCAGGAAGCAACCCGTCTCGGCGTCGTAGC
CGTGACGCAGGATATGCTCGTACTCGGTATCATTCGCGACGGAGACAATGGCGCGATCGACATCATGCGGCACTATGGGA
TCAACTTGTACGAACTCAAACGGTTGATCGAGTTGGAAGCCATCGCCGAGAGTTTGCCTGCTTCGCCTGAGGGATTGCCC
ATCTTCACCCCTTCGGCTCGGGAGGCTATCGATGATGCCACAGACATCTGTGCCGACATGGAGGACGAGGCCGTCAGCCC
GGTCCATCTGTTGCTGAGTATCCTCAACTCGACACAGGAGAGCTTAGTACAAAAGATATTTATGAAACAAGGTATAAAAT
ACGACACCATCCTGTCGGATTACTTCGGACAGCGCAACCCCTCCGAAGGGAAGTCTCCCTCCGAAATGGAGATCCTCGAC
GGGTACCAAGACAACGACTTCGACGACGAAGAGGACGAATCCTCTCCGCCTTCCGGAAATAGCGGGACAGGCGGAGGCTC
CGGCGACGCCCCCGAACAGAATACCGGCGGAGGTGATACTACCACCACGACACGGAGTGGAGGCGACACGCCTGCACTGG
ACACCTTCGGCACCGACATCACTGCCATGGCGGCAGCAGGCAAGCTCGACCCGGTAGTGGGTCGGGAGCAGGAGATCGAA
AGGGTGATACAGATACTCAGCCGGCGCAAAAAGAACAATCCGGTGCTCATCGGCGAACCCGGTGTGGGCAAGAGTGCCAT
CGTGGAAGGACTGGCCGAACGCATCGTGAACAGGAAGGTGAGCCGTATTCTTTTCGACAAGCGGATCATCAGCCTCGATT
TGGCTCAGATGGTAGCCGGCACCAAATATCGCGGACAGTTCGAAGAGCGGTTGAAAGCCGTGCTCGACGAGCTGAAGAAG
AATCCGCAGATCATCCTCTTCATCGACGAGATACATACCATCGTGGGAGCAGGCTCTGCAGCCGGATCGATGGATACGGC
CAATATGCTCAAACCCGCTCTTGCCCGTGGACAGGTACAGTGCATCGGAGCCACTACGCTGGATGAGTATCGTAAGAACA
TAGAAAAGGACGGAGCACTCGAACGCCGCTTCCAGAAGGTGCCGATAGCCCCCTCGACTGCAGAAGAAACGCTGACCATC
CTGCAAAACATCAAAGAGAAATACGAGGACTATCACGGTGTACGCTATACGGACGAAGCGATCAAAGCGGCAGTGGAACT
GACCGATCGCTATGTATCCGATCGCTTCTTCCCCGATAAGGCAATAGATGCCATGGACGAGGCCGGCGCGAGCGTCCATA
TCACCAATGTGGTGGCTCCGAAAGAAATCGAGATACTGGAGGCCGAATTGGCATCGGTGCGAGAGAACAAGCTCTCGGCC
GTAAAGGCTCAGAACTACGAGCTGGCTGCCTCCTTCCGCGATCAGGAGCGGCGCACTCAGCAGCAGATAGCGGAAGAGAA
GAAAAAATGGGAAGAGCAGATGTCCAAGCACCGCGAGACGGTGGACGAGAATGTAGTGGCGCACGTAGTGGCGTTGATGA
CAGGCGTTCCGGCTGAGCGGCTGAGCACGGGCGAAGGCGAACGTCTGCGCACGATGGCAGATGATCTCAAGACCAAAGTA
GTAGGTCAGGACACAGCCATCGAAAAGATGGTGCGTGCCATCCAGCGCAATCGTCTGGGACTTCGCAATGAAAAGAAACC
GATCGGTTCTTTCCTTTTCCTCGGCCCCACGGGGGTAGGCAAGACCTATTTGGCCAAGAAGCTCGCCGAATACCTGTTCG
AGGATGAGAATGCCATGATCAGGGTGGATATGAGCGAGTATATGGAGAAGTTCTCCGTATCGCGTCTCGTGGGTGCCCCT
CCGGGATATGTGGGCTATGAAGAAGGCGGCCAACTGACGGAGCGCGTAAGACGCAAACCCTATTCCGTAGTTCTCTTGGA
TGAGATCGAAAAGGCGCATGCCGATGTCTTCAATCTGCTCTTACAGGTGATGGACGAAGGTCAGCTGACCGACAGTCTGG
GACGGCGCGTGAATTTCAAGAACACCGTGATCATCATCACCTCCAATGTGGGTACACGCCAGCTCAAAGACTTCGGGCAG
GGTATCGGGTTCCGTTCGGAAAAAGACGAGGAAGCGAACAAGGAGCATAGCCGTTCCGTGATCCAAAAAGCTCTGAACAA
GACGTTCAGCCCCGAATTTCTCAACCGTTTGGACGATATCATCCTCTTCGACCAACTGGGCAAGACGGAGATTCGCCGGA
TGGTGGACATAGAGCTTAAAGCCGTCTTGGCGCGCATCCATCGTGCCGGATACGACCTCGTCCTTACCGATGAAGCCAAG
GATGTGATAGCGACGAAGGGATACGACCTCCAATACGGAGCACGACCGCTCAAGCGCACACTCCAGAACGAAGTGGAGGA
TCGCCTCACGGATCTTATCCTCTCCGGACAGATCGAGAAAGGGCAGACGCTTACGCTCTCTGCTCGCGATGGCGAGATCA
TCGTACAAGAACAAGCATAA

Domains

Predicted by InterProScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (586-760)

• ATPase family associated with various cellular activities (AAA) (AAA) (255-383)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (19-64)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-138)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (766-845)

• AAA lid domain (AAA_lid_9) (394-494)

3D structure

• AlphaFold DB: B2RGN2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	44.743	99.651	0.446
clpC	Lactococcus lactis subsp. cremoris KW2	46.06	85.681	0.395
clpE	Streptococcus mutans UA159	50.539	75.553	0.382
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	50.698	75.087	0.381
clpE	Streptococcus pneumoniae R6	49.922	74.389	0.371
clpE	Streptococcus pneumoniae TIGR4	49.922	74.389	0.371
clpE	Streptococcus pneumoniae Rx1	49.922	74.389	0.371
clpE	Streptococcus pneumoniae D39	49.922	74.389	0.371