Detailed information NTG0136844

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RT44_RS09780
• Genome accession: NZ_CP010402
• Coordinates: 1958983..1960026 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GR2
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1953983..1965026

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RT44_RS09750 (RT44_09745)	-	1954405..1955661 (-)	1257	WP_001793428.1	aminopeptidase	-
RT44_RS09755 (RT44_09750)	-	1955664..1955864 (-)	201	WP_000180463.1	DUF1128 family protein	-
RT44_RS09760 (RT44_09755)	-	1956011..1956475 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
RT44_RS09765 (RT44_09760)	-	1956482..1956757 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
RT44_RS09770 (RT44_09765)	-	1957035..1958252 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
RT44_RS09775 (RT44_09770)	vraR	1958364..1958993 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
RT44_RS09780 (RT44_09775)	vraS	1958983..1960026 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RT44_RS09785 (RT44_09780)	liaF	1960023..1960724 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
RT44_RS09790 (RT44_09785)	-	1960739..1961125 (-)	387	WP_001110179.1	hypothetical protein	-
RT44_RS09795 (RT44_09790)	map	1961342..1962100 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RT44_RS09810 (RT44_09805)	-	1962690..1963676 (+)	987	WP_000999718.1	aromatic acid exporter family protein	-
RT44_RS09820 (RT44_09815)	-	1964166..1964579 (-)	414	WP_001837236.1	hypothetical protein	-
RT44_RS09825 (RT44_09820)	-	1964608..1964718 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=136844 RT44_RS09780 WP_001017131.1 1958983..1960026(-) (vraS) [Staphylococcus aureus strain GR2]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=136844 RT44_RS09780 WP_001017131.1 1958983..1960026(-) (vraS) [Staphylococcus aureus strain GR2]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1