Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   HKU360_RS09115 Genome accession   NZ_CP009612
Coordinates   1831788..1834232 (-) Length   814 a.a.
NCBI ID   WP_002991294.1    Uniprot ID   Q1JJL3
Organism   Streptococcus pyogenes strain HKU360     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1826788..1839232
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HKU360_RS09095 (HKU360_01872) - 1826925..1828424 (+) 1500 WP_002991288.1 C69 family dipeptidase -
  HKU360_RS10510 - 1828748..1829089 (+) 342 Protein_1765 NUDIX domain-containing protein -
  HKU360_RS09100 (HKU360_01873) - 1829102..1829402 (-) 301 Protein_1766 helix-turn-helix domain-containing protein -
  HKU360_RS09105 (HKU360_01874) groL 1829653..1831284 (-) 1632 WP_002982320.1 chaperonin GroEL -
  HKU360_RS09110 (HKU360_01875) groES 1831320..1831610 (-) 291 WP_002991292.1 co-chaperone GroES -
  HKU360_RS09115 (HKU360_01876) clpC 1831788..1834232 (-) 2445 WP_002991294.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  HKU360_RS09120 (HKU360_01877) - 1834232..1834693 (-) 462 WP_002991297.1 CtsR family transcriptional regulator -
  HKU360_RS09125 (HKU360_01879) - 1834889..1835092 (-) 204 WP_002991299.1 cold-shock protein -
  HKU360_RS09135 (HKU360_01881) ahpC 1836087..1836647 (+) 561 WP_002982304.1 alkyl hydroperoxide reductase subunit C -
  HKU360_RS09140 (HKU360_01882) ahpF 1836668..1838200 (+) 1533 WP_002991301.1 alkyl hydroperoxide reductase subunit F -

Sequence

Protein


Download         Length: 814 a.a.        Molecular weight: 90656.37 Da        Isoelectric Point: 6.9601

>NTDB_id=130755 HKU360_RS09115 WP_002991294.1 1831788..1834232(-) (clpC) [Streptococcus pyogenes strain HKU360]
MIMYSTKMQDIFRQAQFQAARFDSHCLETWHVLLAMVAVDNSLANMILSEYDAQVAIEEYEAAAILAMGKTPKEQLSRVD
FRPQSKTLTNLLAFAQAISQITRDQEVGSEHVLFAILLNPDIMASRLLEIAGYQIKDNGNGQPRLADLRKAIERHAGYSK
EMIKAIHELRKPKKTKTQGTFSDMMKPPSTAGELSDFTRDLTEMARQGLLESVIGRDQEVSRMIQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIANGAIPYELKEMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIEADGQIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNTEDAYQILMGLKLSYETYHNVSISN
EAVKTAVKMAHRYLTSKNLPDSAIDLLDEASAAVQNMVKKSAPETLTPIDQALINGDMKKVSRLLAKEAKGQMRKPTPVT
EDDILATLSKLSGIPLEKLTQADSKKYLNLEKELHKRVIGQDAAVTAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDDEAALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTQKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGILTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGVKGIHQDHQAMEKRILEELRKTYRPEFINRIDEKVVFH
SLTQDNMRDVVKIMVQPLITTLAEKGITLKIQPLALKHLSEVGYDEHMGARPLRRTLQTEIEDKLSELILSRELTSGHTL
KIGLSHGKLTFHIA

Nucleotide


Download         Length: 2445 bp        

>NTDB_id=130755 HKU360_RS09115 WP_002991294.1 1831788..1834232(-) (clpC) [Streptococcus pyogenes strain HKU360]
ATGATTATGTATTCAACGAAGATGCAAGACATTTTTAGACAGGCGCAGTTCCAAGCTGCTCGCTTTGATAGCCATTGCCT
GGAAACTTGGCATGTTTTGTTAGCTATGGTAGCTGTAGATAATTCTTTAGCAAATATGATTTTAAGTGAATATGATGCCC
AAGTCGCCATAGAAGAATATGAAGCTGCAGCTATTTTAGCCATGGGCAAAACCCCTAAGGAACAGTTGTCTCGTGTAGAC
TTCAGACCTCAATCTAAAACCTTGACTAACTTGTTAGCTTTTGCGCAGGCTATTAGCCAAATCACTAGGGATCAAGAAGT
CGGCTCTGAGCATGTCTTATTTGCTATTTTATTGAATCCAGATATCATGGCGAGTCGTTTGTTAGAAATAGCAGGCTATC
AGATAAAAGATAACGGCAATGGGCAGCCGCGATTAGCTGACTTGCGAAAAGCAATAGAACGTCATGCAGGTTACAGTAAG
GAAATGATTAAGGCTATTCACGAACTACGTAAGCCTAAAAAAACGAAAACACAAGGGACCTTTTCAGATATGATGAAGCC
ACCAAGTACAGCTGGTGAGTTGAGTGATTTCACAAGAGATTTGACTGAAATGGCAAGACAAGGTTTGTTAGAATCGGTGA
TTGGACGTGACCAAGAAGTATCTCGTATGATTCAGGTACTAAGTCGTAAAACGAAAAACAATCCTGTCTTGGTAGGTGAT
GCAGGTGTTGGTAAAACTGCGCTTGCTTATGGCCTTGCTCAACGGATTGCAAATGGCGCTATTCCTTATGAACTTAAGGA
GATGCGTGTCCTAGAATTAGACATGATGAGTGTGGTAGCAGGAACCCGTTTTCGTGGGGATTTTGAAGAGCGCATGAATC
AAATCATTGATGATATTGAAGCTGATGGTCAGATTATTCTTTTTGTTGATGAACTACATACTATTATGGGATCTGGCAGT
GGTATTGACAGTACACTTGATGCGGCTAACATTTTAAAACCAGCATTATCGCGCGGCACTCTTCATATGGTTGGAGCAAC
AACTCAAGAAGAATATCAAAAACATATTGAAAAAGATGCAGCTCTTTCGCGTCGTTTTGCTAAAATATTAATTGAAGAAC
CTAATACAGAAGATGCTTATCAGATTTTGATGGGCCTAAAATTATCTTATGAGACCTACCATAATGTCTCGATATCAAAT
GAGGCAGTTAAAACAGCTGTAAAAATGGCACACCGTTATTTAACCAGTAAAAATCTCCCTGATTCAGCTATCGATTTATT
AGATGAAGCTAGTGCTGCTGTGCAAAACATGGTGAAAAAATCAGCACCTGAGACTTTAACACCAATAGACCAAGCTCTTA
TCAATGGTGATATGAAAAAAGTATCTCGCCTCTTAGCTAAAGAAGCAAAAGGTCAGATGAGAAAACCAACACCAGTCACA
GAAGATGATATTTTGGCAACCTTGAGTAAGTTATCGGGAATTCCACTTGAAAAACTGACGCAAGCTGATAGCAAAAAATA
CCTCAATTTAGAAAAAGAACTGCATAAGCGTGTGATTGGTCAGGATGCTGCTGTTACGGCTATTTCAAGAGCCATTCGTC
GCAATCAGTCAGGTATTCGAACAGGAAAACGTCCTATTGGATCATTTATGTTTCTTGGCCCAACAGGAGTAGGTAAGACA
GAACTAGCAAAGGCCCTTGCAGAAGTTCTCTTTGATGATGAAGCAGCGCTTATTCGTTTTGATATGTCTGAGTACATGGA
AAAATTCGCAGCGTCTAGGCTTAATGGAGCACCTCCTGGTTATGTCGGCTATGATGAAGGAGGTGAACTGACACAGAAAG
TTAGAAATAAACCTTATTCAGTCTTGCTTTTTGATGAAGTGGAAAAAGCACATCCTGATATTTTTAACGTTCTCCTTCAA
GTATTAGATGATGGTATATTGACTGATAGTCGTGGGCGTAAGGTCGATTTTTCAAATACTATTATTATCATGACCAGCAA
TCTTGGCGCAACAGCCCTGCGTGATGATAAAACGGTCGGTTTTGGGGTCAAAGGCATTCACCAAGACCATCAAGCTATGG
AGAAACGTATCTTAGAAGAATTAAGAAAAACTTACCGCCCAGAATTTATCAATCGTATTGATGAAAAAGTGGTCTTTCAT
AGTCTGACCCAAGATAACATGCGCGATGTGGTTAAAATCATGGTACAGCCCCTGATTACTACATTGGCAGAAAAAGGTAT
TACCCTTAAAATTCAGCCTTTGGCCTTGAAACATTTGTCCGAGGTCGGCTATGATGAACATATGGGGGCAAGACCATTAC
GTCGAACGCTGCAAACTGAGATAGAAGATAAGCTATCAGAGCTTATCCTTTCTCGAGAATTGACAAGTGGGCATACGCTA
AAAATTGGATTATCACATGGCAAATTAACGTTTCACATAGCTTAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(544-715)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(722-801)

AAA lid domain (AAA_lid_9)

(376-459)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(95-130)

ATPase family associated with various cellular activities (AAA) (AAA)

(236-368)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q1JJL3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus mutans UA159

75.154

99.877

0.751
  clpC Streptococcus thermophilus LMG 18311

71.324

100

0.715
  clpC Streptococcus thermophilus LMD-9

71.201

100

0.714
  clpC Streptococcus pneumoniae TIGR4

65.971

100

0.66
  clpC Streptococcus pneumoniae Rx1

65.971

100

0.66
  clpC Streptococcus pneumoniae D39

65.971

100

0.66
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.852

100

0.493
  clpC Bacillus subtilis subsp. subtilis str. 168

42.326

100

0.434

Multiple sequence alignment