Detailed information NTG0130722

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: lpt_RS08470
• Genome accession: NZ_CP012019
• Coordinates: 1911971..1914547 (+)
• Length: 858 a.a.
• NCBI ID: WP_011214015.1
• Uniprot ID: -
• Organism: Legionella pneumophila subsp. pneumophila strain Toronto-20052
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 1906971..1919547

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
lpt_RS08440 (lpt_08425)	-	1907248..1907616 (-)	369	WP_011214010.1	iron-sulfur cluster assembly accessory protein	-
lpt_RS08445 (lpt_08430)	-	1907621..1908004 (-)	384	WP_061784307.1	iron-sulfur cluster assembly scaffold protein	-
lpt_RS08450 (lpt_08435)	-	1908001..1909158 (-)	1158	WP_032832465.1	IscS subfamily cysteine desulfurase	-
lpt_RS08455 (lpt_08440)	trmJ	1909139..1909912 (-)	774	WP_061784308.1	tRNA (cytosine(32)/uridine(32)-2'-O)-methyltransferase TrmJ	-
lpt_RS08460 (lpt_08445)	-	1910028..1910813 (+)	786	WP_027221054.1	inositol monophosphatase family protein	-
lpt_RS08465 (lpt_08450)	-	1910926..1911882 (-)	957	WP_011215725.1	S49 family peptidase	-
lpt_RS08470 (lpt_08455)	clpC	1911971..1914547 (+)	2577	WP_011214015.1	ATP-dependent chaperone ClpB	Regulator
lpt_RS08475 (lpt_08460)	-	1914639..1915952 (-)	1314	WP_027221055.1	lpg1751 family Dot/Icm T4SS effector	-
lpt_RS08480 (lpt_08465)	-	1915965..1916612 (-)	648	WP_072356259.1	lpg1752 family Dot/Icm T4SS effector	-
lpt_RS08485 (lpt_08470)	mpl	1916905..1918272 (-)	1368	WP_027221056.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-
lpt_RS08490 (lpt_08475)	-	1918274..1918894 (-)	621	WP_027221057.1	hypothetical protein	-

Sequence

Protein

• Length: 858 a.a.
• Molecular weight: 95794.66 Da
• Isoelectric Point: 5.3669

>NTDB_id=130722 lpt_RS08470 WP_011214015.1 1911971..1914547(+) (clpC) [Legionella pneumophila subsp. pneumophila strain Toronto-20052]
MRMDKLTSKFQMALADAQSLALGRDNGFIEPEHLMKALLDQQGGSCRPLLSKAGVNIPLLRTLIDQALDKLPKVSGTGGD
IHISNALNRLLNLTDKLSQQRKDNFISSELFVLAAINEDSNLAKILKQAGGDNKAIEKAIDELRGGETVNDPNAEEQRQA
LEKYTLDLTERAEQGKLDPVIGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKNKRLLAL
DMGALIAGAKYRGEFEERLKGVLNDLAKQEGQIILFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCIGATTLDEYR
QYIEKDAALERRFQKVLVDEPSVEDTIAILRGLKERYEVHHGVEITDPALVAAAMLSHRYISDRQLPDKAIDLIDEAASL
IRMEIDSKPESMDKLERRLIQLKIEREALKKENDEASKKRLVDLQKSIDELEQNYSDLEEIWKAEKATMQGSTQIKEALE
QAKLEMETARRAGDLSRMSELQYGRIPELEKRLSQVSSVDAMETKLVRNKVTEDEIAEVVSKWTGIPVSKMMEGEKEKLL
KMEEALHSRLIGQNEAVDAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALASFLFDTEEAMVRIDMSEFMEK
HSVARLIGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHTDVFNILLQVMDDGRLTDGQGRTVDFRNTVIVMTSNL
GSQLIQEMSSKFNYDEIKAAVMDLVSQHFRPEFINRIDESVVFHSLTKEQIAKIAAIQINYLHHRLKQQNITLEVTSEAL
SHLAEAGFDPVYGARPLKRTIQQKLENPLAQSLLTGKFKSGDTIIVSYKDGVMEFSKQ

Nucleotide

• Length: 2577 bp

>NTDB_id=130722 lpt_RS08470 WP_011214015.1 1911971..1914547(+) (clpC) [Legionella pneumophila subsp. pneumophila strain Toronto-20052]
ATGCGAATGGACAAACTAACATCAAAGTTTCAAATGGCTCTTGCAGATGCCCAATCCCTGGCTTTAGGTAGAGACAATGG
ATTTATAGAACCAGAACATTTAATGAAAGCCTTACTTGATCAGCAAGGCGGAAGTTGCAGACCTCTTCTCAGTAAAGCGG
GTGTTAATATACCACTATTAAGAACTTTAATTGACCAAGCTCTGGATAAACTACCTAAAGTATCAGGCACCGGAGGAGAT
ATTCATATATCTAATGCTTTGAATAGACTACTTAACCTGACTGACAAACTATCGCAACAAAGAAAAGATAACTTTATTTC
AAGCGAGCTTTTTGTATTAGCAGCGATAAATGAGGATAGTAACCTTGCAAAAATACTCAAACAAGCCGGGGGTGACAACA
AAGCAATTGAAAAAGCGATTGATGAGTTAAGAGGTGGAGAAACGGTTAATGATCCAAATGCAGAGGAACAGCGACAAGCC
CTTGAAAAATATACACTGGATCTGACTGAACGTGCCGAGCAAGGAAAATTGGATCCAGTGATTGGACGAGATGATGAAAT
CAGACGCACCATCCAGGTATTGCAAAGAAGAACCAAAAATAACCCTGTATTAATAGGTGAACCTGGTGTTGGTAAAACAG
CCATAGTAGAAGGTTTGGCACAACGAATTATTAATGGTGAGGTACCTGAAGGATTAAAGAATAAACGCTTACTGGCATTG
GACATGGGTGCCTTGATCGCAGGTGCAAAATATCGTGGAGAGTTTGAAGAGCGTTTAAAAGGTGTGCTTAATGATTTGGC
AAAACAAGAGGGTCAAATCATATTATTTATTGATGAATTACACACTATGGTTGGCGCTGGCAAGGCTGAAGGAGCTATGG
ATGCCGGGAATATGCTCAAGCCAGCATTGGCTAGAGGTGAATTGCATTGCATTGGGGCTACGACATTAGACGAATACCGA
CAATACATTGAAAAGGATGCTGCTCTTGAACGACGCTTTCAAAAAGTACTGGTCGATGAACCCAGTGTGGAAGACACTAT
CGCTATATTAAGGGGACTTAAAGAACGTTATGAAGTTCACCATGGAGTTGAAATTACAGATCCCGCTTTGGTTGCTGCCG
CAATGCTATCCCATCGTTACATCAGCGACCGTCAGCTACCTGATAAAGCCATTGATTTAATTGATGAAGCCGCCAGCTTA
ATCCGGATGGAAATTGATTCAAAACCAGAAAGTATGGATAAACTGGAACGACGTTTGATTCAGCTAAAAATCGAGCGTGA
AGCATTGAAAAAGGAAAATGACGAAGCGTCTAAAAAAAGACTTGTTGATTTACAAAAAAGTATCGATGAATTAGAGCAAA
ATTATTCAGACTTAGAAGAAATTTGGAAAGCTGAAAAAGCGACCATGCAAGGATCCACTCAAATCAAAGAAGCACTTGAA
CAAGCCAAACTGGAAATGGAAACTGCAAGGAGAGCAGGAGATTTAAGTCGCATGTCCGAATTACAATATGGGCGTATACC
CGAGCTGGAAAAAAGATTAAGCCAGGTCTCTTCCGTCGATGCTATGGAAACAAAGTTGGTACGCAATAAAGTTACCGAAG
ATGAGATCGCAGAAGTTGTTTCAAAATGGACAGGAATCCCAGTATCTAAAATGATGGAAGGAGAAAAGGAAAAACTGCTG
AAAATGGAAGAAGCTTTGCACAGTAGACTCATTGGCCAGAATGAAGCGGTGGATGCTGTTTCTAATGCCATAAGACGGTC
ACGCGCAGGCCTGTCTGATCCTAATCGTCCAATTGGTTCATTTCTTTTTCTGGGGCCAACTGGTGTGGGGAAAACTGAAC
TATGTAAAGCACTTGCTTCTTTTCTTTTTGATACGGAAGAGGCGATGGTGCGCATTGATATGTCTGAATTTATGGAAAAA
CACTCTGTTGCGCGCTTAATCGGAGCGCCTCCTGGCTATGTAGGATATGAGGAGGGTGGTTATTTAACTGAAGCAGTCAG
ACGCAGGCCCTATTCTGTTATCTTACTTGATGAAGTAGAAAAAGCTCATACAGATGTATTTAATATTCTGCTTCAAGTTA
TGGATGATGGCCGTCTAACAGATGGTCAGGGACGTACTGTTGACTTTAGGAATACCGTTATTGTTATGACCTCTAATCTG
GGATCTCAACTCATTCAGGAAATGAGCAGCAAATTTAATTACGATGAGATTAAGGCTGCGGTAATGGATTTAGTCAGCCA
ACATTTCAGACCTGAATTTATCAACAGAATTGATGAATCGGTGGTATTCCATTCCTTGACAAAAGAACAAATTGCAAAAA
TTGCAGCAATCCAGATTAACTATTTACATCATCGGCTGAAACAACAAAACATCACTCTTGAAGTCACAAGTGAGGCTTTA
TCTCATTTGGCTGAAGCAGGATTTGATCCGGTCTATGGTGCCCGCCCTCTAAAACGTACTATTCAGCAAAAATTAGAGAA
TCCCCTAGCGCAATCATTATTGACTGGAAAATTTAAATCAGGGGATACCATTATTGTATCTTATAAAGACGGAGTAATGG
AATTTTCCAAGCAATGA

Domains

Predicted by InterProScan.

• AAA lid domain (AAA_lid_9) (342-444)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (766-846)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-68)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-145)

• AAA domain (Cdc48 subfamily) (AAA_2) (596-759)

• ATPase family associated with various cellular activities (AAA) (AAA) (203-335)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	47.066	100	0.477
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	41.176	100	0.416
clpC	Lactococcus lactis subsp. cremoris KW2	46.454	80.536	0.374
clpE	Streptococcus mutans UA159	46.097	79.138	0.365
clpE	Streptococcus pneumoniae TIGR4	45.283	80.303	0.364
clpE	Streptococcus pneumoniae Rx1	45.283	80.303	0.364
clpE	Streptococcus pneumoniae D39	45.283	80.303	0.364
clpE	Streptococcus pneumoniae R6	45.283	80.303	0.364