Detailed information    

experimental Experimentally validated

Overview

Name   rocC   Type   Regulator
Locus tag   LPP_RS00740 Genome accession   NC_006368
Coordinates   165251..165943 (+) Length   230 a.a.
NCBI ID   WP_011212783.1    Uniprot ID   -
Organism   Legionella pneumophila str. Paris     
Function   rocR chaperone; repress natural transformation   
Competence regulation

Function

RocC stabilizes RocR and this ribonucleoprotein complex can bind the mRNAs of genes of the competence regulon via a conserved 6-nt sequence called RocR box and promote their degradation.


Genomic Context

Location: 160251..170943
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LPP_RS16345 (lpp0144) - 160872..161048 (-) 177 WP_011212779.1 dodecin domain-containing protein -
  LPP_RS00725 (lpp0145) - 161226..163694 (+) 2469 WP_011212780.1 hypothetical protein -
  LPP_RS00730 (lpp0146) dapB 163798..164529 (-) 732 WP_011212781.1 4-hydroxy-tetrahydrodipicolinate reductase -
  LPP_RS00735 (lpp0147) - 164709..164894 (-) 186 WP_011212782.1 hypothetical protein -
  LPP_RS00740 (lpp0148) rocC 165251..165943 (+) 693 WP_011212783.1 ProQ/FinO family protein Regulator
  LPP_RS00745 (lpp0149) - 165944..167014 (+) 1071 WP_011212784.1 hypothetical protein -

Regulatory network

Positive effect      
Negative effect
Regulator Target Regulation
  rocC rocR positive effect
  rocR comEA negative effect
  rocC comEA negative effect

Sequence

Protein


Download         Length: 230 a.a.        Molecular weight: 25773.65 Da        Isoelectric Point: 10.6563

>NTDB_id=1286 LPP_RS00740 WP_011212783.1 165251..165943(+) (rocC) [Legionella pneumophila str. Paris]
MRKQALHPRTAVINKAQKNQSKRARSDALLWLAANFPEAFDNSLRIRPLKIGIMSDILQHAEKAEQVGVSKSKLREAVVL
FTRRLDYLACLKAREVRIDLHGNPVAEVTEEEAENASMKIKKRVEKSVKNARKQVNAKAANHSYVNNQPSTVSSVKPMNS
FDSHPEPLLPIYPLRSSTYASQNVAMQSAKSPSVVVKHKAPKQYDPDAVARLKEKLGLSRKAEDKKETTE

Nucleotide


Download         Length: 693 bp        

>NTDB_id=1286 LPP_RS00740 WP_011212783.1 165251..165943(+) (rocC) [Legionella pneumophila str. Paris]
ATGAGAAAGCAGGCGCTGCACCCACGAACCGCTGTCATCAATAAAGCACAAAAAAATCAATCCAAGCGCGCGCGATCTGA
CGCATTATTATGGCTTGCGGCTAATTTCCCTGAGGCATTCGATAATTCTTTGCGTATTCGGCCATTAAAGATTGGTATTA
TGTCTGATATATTGCAGCATGCAGAAAAAGCAGAGCAAGTTGGAGTTTCTAAAAGCAAATTAAGGGAAGCTGTTGTTCTT
TTTACCCGTCGTCTTGATTATCTGGCTTGCCTGAAAGCTCGTGAAGTCCGTATCGATTTGCATGGAAATCCAGTAGCGGA
GGTTACTGAGGAAGAAGCGGAGAATGCTTCCATGAAAATTAAAAAACGCGTGGAAAAGAGTGTTAAAAATGCTCGCAAAC
AAGTGAATGCAAAAGCGGCTAATCATTCATATGTAAATAATCAGCCAAGTACAGTTTCCAGCGTTAAGCCAATGAATTCG
TTTGACTCTCATCCTGAGCCTCTTTTGCCAATATATCCTCTCAGAAGCTCTACCTATGCCTCACAAAATGTGGCAATGCA
ATCCGCCAAGTCACCATCCGTAGTAGTCAAACATAAAGCACCAAAGCAATATGATCCGGATGCTGTAGCTCGTTTAAAAG
AAAAATTAGGATTGTCTCGAAAAGCAGAAGATAAAAAGGAAACAACAGAGTAA

Domains

Predicted by InterProScan.

ProQ/FINO family (ProQ)

(26-132)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value

References

[1] Laetitia Attaiech et al. (2016) Silencing of natural transformation by an RNA chaperone and a multitarget small RNA. Proceedings of The National Academy of Sciences of The United States of America 113(31):8813-8. [PMID: 27432973]