Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   SpyM6D471_RS03400 Genome accession   NZ_CP011415
Coordinates   674483..676582 (-) Length   699 a.a.
NCBI ID   WP_011184415.1    Uniprot ID   Q5XCL7
Organism   Streptococcus pyogenes strain D471     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 669483..681582
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SpyM6D471_RS03370 (SpyM6D471_03365) - 669960..670799 (+) 840 WP_011017679.1 thymidylate synthase -
  SpyM6D471_RS03375 (SpyM6D471_03370) - 670879..671376 (+) 498 WP_011184412.1 dihydrofolate reductase -
  SpyM6D471_RS09610 (SpyM6D471_03375) - 671396..671566 (+) 171 WP_002990165.1 hypothetical protein -
  SpyM6D471_RS03385 (SpyM6D471_03380) clpX 671696..672925 (+) 1230 WP_011888976.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  SpyM6D471_RS03390 (SpyM6D471_03385) yihA 672935..673534 (+) 600 WP_011184414.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  SpyM6D471_RS03395 (SpyM6D471_03390) - 673682..674425 (+) 744 WP_002984942.1 hypothetical protein -
  SpyM6D471_RS03400 (SpyM6D471_03395) clpC 674483..676582 (-) 2100 WP_011184415.1 AAA family ATPase Regulator
  SpyM6D471_RS03405 (SpyM6D471_03400) rpiA 676961..677644 (+) 684 WP_011184416.1 ribose-5-phosphate isomerase RpiA -
  SpyM6D471_RS03410 (SpyM6D471_03405) - 677721..678932 (+) 1212 WP_023078417.1 phosphopentomutase -
  SpyM6D471_RS03415 (SpyM6D471_03410) arsC 678951..679391 (+) 441 WP_021340256.1 arsenate reductase (glutaredoxin) -
  SpyM6D471_RS03420 (SpyM6D471_03415) - 679375..680184 (+) 810 WP_002984930.1 purine-nucleoside phosphorylase -
  SpyM6D471_RS03425 (SpyM6D471_03420) deoD 680847..681560 (+) 714 WP_002984928.1 purine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 699 a.a.        Molecular weight: 77429.48 Da        Isoelectric Point: 5.6670

>NTDB_id=128015 SpyM6D471_RS03400 WP_011184415.1 674483..676582(-) (clpC) [Streptococcus pyogenes strain D471]
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLG
TNLTQEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSL
EAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAA
QHPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMRT
NDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNT
VIIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNSIIKFNHLQKENLEEIVDLMLAEVNQTTAKKGISLTIADDA
KAHLIDLGYNHAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ

Nucleotide


Download         Length: 2100 bp        

>NTDB_id=128015 SpyM6D471_RS03400 WP_011184415.1 674483..676582(-) (clpC) [Streptococcus pyogenes strain D471]
ATGACACATTTTTCTGGTAAAGATCCTTTTGTAAATATGGATGATATTTTCAACCAATTAATGGCAAACATGGGTGGTTA
TCGTAGCGAAAATCCCCGCTATCTCGTTAACGGTCGCGAAATAACTCCCGAAGAATTCCAACACTATCGTCAAACAGGAC
AACTCCCTGTAGCAACAACCAAAGCAACAAATTCTCAAATGTTAACACCTAAAGCTGATAGTGTATTGACTCAACTCGGA
ACTAACTTAACACAAGAAGCTCGTCAAGGGCATCTTGACCCCGTCATTGGTCGTAACAAAGAAATTCAAGATACCGCTGA
AATCTTGGCACGACGAACTAAAAATAATCCTGTCCTTGTCGGAGATGCTGGTGTCGGTAAAACTGCAGTCATTGAAGGTT
TAGCTCAAGCCATTGTTAATGGAGATGTCCCAGCCGCTATTAAAAACAAGGAAATCGTATCAATTGACATTTCTAGTCTT
GAAGCTGGTACACAGTATCGTGGCTCCTTTGAAGAGACCATTCAAAACTTGATTCAAGAAGTAAAAGAAGCTGGGAATAT
CATCTTATTTTTTGATGAAATTCATCAAATAGTTGGTGCTGGTGCCACAAGCAGTGATTCAGGCTCAAAGGGACTTGCAG
ATATTCTTAAACCAGCCTTGTCACGAGGAGAATTAACACTGATTGGTGCTACTACTCAAGACGAATACCGCAATACTATT
TTAAAAAATGCTGCTCTTGCTCGTCGCTTTAATGAAGTTAAAGTGAATGCACCATCAGCTGAAGATACTTTTCACATTTT
AATGGGTATTCGTAATCTTTATGAACAACACCACCATATTACCCTTCCTGATAATGTTCTAAAAGCTGCTGTTGATTATT
CTATTCAATACATCCCACAGCGTAGCCTGCCAGATAAAGCAATTGACTTACTGGATATGACAGCTGCTCATTTAGCTGCG
CAACACCCGGTCACTGACTTAAAAACACTCGAAACTGAAATAGCTAAACAAAAAGAGAGTCAAGAAAAAGCTGTCGCCAA
AGAAGACTTTGAAAAAGCTTTAGCAGCAAAAACACGGATTGAAACATTACAAAAGCAAATTGAGCAACATAACCAAAGCC
AAAATGTTACTGCTACAGTCAATGATATCGCAGAGTCTGTAGAGCGCTTAACTGGTATTCCTGTCTCTAACATGAGGACT
AATGATTTAGAAAGGCTCAAAGGAATTAGCAGCCGCTTAAAAAGCCATGTCATCGGACAAGATGAGGCTGTCGCAGCAGT
AGCACGTGCTATTCGACGAAATCGAGCAGGTTTTGATGATGGTAACCGTCCAATAGGTTCTTTCCTTTTTGTGGGTCCAA
CTGGTGTTGGTAAAACAGAGTTAGCTAAACAATTAGCACTTGATTTATTTGGTTCCAAAGATGCTATTATTCGACTTGAT
ATGTCCGAATATAACGATCGCACTGCTGTGTCAAAATTGATTGGGACAACGGCTGGTTATGTTGGCTACGATGATAATAA
TAATACCCTAACTGAGCGTGTTCGTCGTAACCCTTATGCTATTGTCTTACTAGATGAAATTGAAAAAGCTGATCCTCAAA
TCATTACACTTCTTCTACAAGTGTTAGATGATGGACGATTGACAGATGGACAAGGAAATACTATTAACTTTAAAAATACC
GTTATTATTGCTACATCAAATGCCGGTTTTGGCCAACAAGATACGGAAACTTCTGAGTCTAACATTATGGATCGCATTGC
ACCTTATTTCAGACCAGAGTTTTTGAACCGTTTTAATAGTATCATTAAATTTAATCATCTGCAAAAAGAAAATTTAGAAG
AAATTGTTGATTTAATGCTAGCTGAAGTAAATCAAACCACCGCAAAAAAAGGTATTAGTTTAACGATTGCTGATGACGCT
AAAGCTCATTTGATAGATTTAGGGTACAATCACGCTATGGGAGCTCGTCCATTACGACGTATTATCGAACAGGAAATTCG
TGACCGTATAACTGATTATTATCTTGACCATCCAGAAGTCAAAAAACTTCAGGCAATCCTAAAAGAAGGACAACTAGTGA
TTAGGCAAAACGATCAGTAA

Domains

Predicted by InterProScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(607-678)

ATPase family associated with various cellular activities (AAA) (AAA)

(118-250)

AAA lid domain (AAA_lid_9)

(259-353)

AAA domain (Cdc48 subfamily) (AAA_2)

(443-600)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5XCL7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Lactococcus lactis subsp. cremoris KW2

47.084

100

0.474
  clpE Streptococcus mutans UA159

49.224

92.132

0.454
  clpE Streptococcus pneumoniae TIGR4

49.438

89.127

0.441
  clpE Streptococcus pneumoniae Rx1

49.438

89.127

0.441
  clpE Streptococcus pneumoniae D39

49.438

89.127

0.441
  clpE Streptococcus pneumoniae R6

49.438

89.127

0.441
  clpC Bacillus subtilis subsp. subtilis str. 168

44.662

95.136

0.425
  clpC Streptococcus thermophilus LMD-9

42.79

91.273

0.391
  clpC Streptococcus pneumoniae Rx1

41.871

93.276

0.391
  clpC Streptococcus pneumoniae D39

41.871

93.276

0.391
  clpC Streptococcus thermophilus LMG 18311

42.633

91.273

0.389
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

41.348

93.419

0.386
  clpC Streptococcus pneumoniae TIGR4

42.857

90.129

0.386
  clpC Streptococcus mutans UA159

41.719

91.559

0.382

Multiple sequence alignment