Detailed information NTG0126458

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: NCDO2118_RS11830
• Genome accession: NZ_CP009054
• Coordinates: 2419851..2420879 (-)
• Length: 342 a.a.
• NCBI ID: WP_003132657.1
• Uniprot ID: S6FVM6
• Organism: Lactococcus lactis subsp. lactis NCDO 2118
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2414851..2425879

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NCDO2118_RS11815 (NCDO2118_2262)	-	2415925..2416782 (-)	858	WP_012898643.1	Rgg/GadR/MutR family transcriptional regulator	-
NCDO2118_RS11820 (NCDO2118_2263)	-	2416893..2418032 (-)	1140	WP_012898644.1	MFS transporter	-
NCDO2118_RS11825 (NCDO2118_2264)	kwcM	2418029..2419348 (-)	1320	WP_012898645.1	KxxxW cyclic peptide radical SAM maturase	-
NCDO2118_RS13050	-	2419416..2419529 (-)	114	WP_011836076.1	KxxxW-cyclized peptide pheromone	-
NCDO2118_RS11830 (NCDO2118_2265)	sepM	2419851..2420879 (-)	1029	WP_003132657.1	SepM family pheromone-processing serine protease	Regulator
NCDO2118_RS11835 (NCDO2118_2266)	coaD	2420866..2421363 (-)	498	WP_010906348.1	pantetheine-phosphate adenylyltransferase	-
NCDO2118_RS11840 (NCDO2118_2267)	rsmD	2421411..2421950 (-)	540	WP_003132655.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
NCDO2118_RS11845 (NCDO2118_2268)	-	2422121..2423341 (-)	1221	WP_012898647.1	MDR family MFS transporter	-
NCDO2118_RS11850 (NCDO2118_2269)	lmrP	2423425..2424651 (-)	1227	WP_012898648.1	multidrug efflux MFS transporter LmrP	-
NCDO2118_RS11855 (NCDO2118_2270)	-	2424839..2425333 (+)	495	WP_012898649.1	RNA polymerase sigma factor	-

Sequence

Protein

• Length: 342 a.a.
• Molecular weight: 37349.96 Da
• Isoelectric Point: 9.9183

>NTDB_id=126458 NCDO2118_RS11830 WP_003132657.1 2419851..2420879(-) (sepM) [Lactococcus lactis subsp. lactis NCDO 2118]
MKKNKKINPKLKWGISIGLIVVALLALFYPTSYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYSH
FNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAIYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELADTITAV
NGQQFTSSADMIAYVSKQKVGDSVTIEYTRIDGTKHKSTGKYIKIANGKTGIGISLVDHTEVVTTPKVTVNAGSIGGPSA
GMMFTLEIYSQLTGKDLRNGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAKK
LKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1029 bp

>NTDB_id=126458 NCDO2118_RS11830 WP_003132657.1 2419851..2420879(-) (sepM) [Lactococcus lactis subsp. lactis NCDO 2118]
ATGAAAAAAAATAAAAAAATTAATCCCAAATTAAAATGGGGAATCTCGATTGGTCTAATTGTTGTTGCCCTTTTAGCTTT
ATTTTATCCAACGAGTTACTATGTGGAAATGCCCGGAACAACCGAGCCTTTAGGGAAAATGGTCAAAGTTGAAGGCAAAA
AAGATGAACATAAAGGTGATTTTTTTCTGACGACTGTCCAAATTGCACGAGCAAATCTTGCTACAATGATTTACAGCCAT
TTTAATAGTTTTACAAGCATTTACAGTGAGCAAGAAATGACTGGTGGACTTAACGACGCACAGTTCAACCGTGTCAACCA
GTTTTACATGGAAACGGCACAGAATACAGCGATTTATCAAGCTTTTAAATTAGCTAATAAACCTTATGAACTTAAATATG
AAGGCGTTTATGTCCTTGATATTGCCAAAAATTCGACCTTTAAAAATAAGCTAGAACTTGCAGATACGATTACAGCAGTC
AATGGTCAACAGTTTACATCAAGTGCCGACATGATTGCTTATGTTTCCAAACAAAAAGTCGGTGATTCAGTAACGATTGA
ATACACGAGAATTGACGGCACAAAGCACAAGTCAACTGGCAAATACATCAAAATTGCTAATGGAAAAACAGGAATTGGGA
TCAGCCTAGTTGACCATACTGAAGTCGTGACGACTCCAAAAGTTACTGTCAACGCGGGTTCAATCGGTGGTCCCTCTGCG
GGGATGATGTTTACACTAGAAATTTACAGTCAGTTGACAGGAAAAGATTTGCGAAACGGTCGCGAAATTGCTGGAACTGG
GACGATTGAACATGACGGAAGCATTGGCCAAATCGGCGGTGTTGATAAAAAAGTAGCCACAGCGAGCAAAGAAGGGGCAA
AAGTCTTCTTAGTGCCTGACTCAGGCACCAAAAAAGAAAGTAGCAACAATTACCTTGGAGCCAAAGCCGCCGCTAAAAAA
CTAAAAACGAAGATGAAAATCGTTCCCGTCAAAACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (134-194)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (227-338)

3D structure

• AlphaFold DB: S6FVM6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.491