Detailed information NTG0124684

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: TO73_RS09335
• Genome accession: NZ_CP010822
• Coordinates: 1759700..1762264 (+)
• Length: 854 a.a.
• NCBI ID: WP_003049377.1
• Uniprot ID: A0ABM5VP39
• Organism: Thermus aquaticus Y51MC23
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 1754700..1767264

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
TO73_RS09295 (TO73_1931)	cmk	1754931..1755557 (+)	627	WP_003049360.1	(d)CMP kinase	-
TO73_RS09300 (TO73_1932)	-	1755560..1756342 (+)	783	WP_003049362.1	CDP-alcohol phosphatidyltransferase family protein	-
TO73_RS09305 (TO73_1933)	-	1756297..1756707 (+)	411	WP_003049364.1	NUDIX domain-containing protein	-
TO73_RS09310 (TO73_1934)	tmpR	1756704..1757408 (+)	705	WP_003049367.1	bifunctional dihydropteridine reductase/dihydrofolate reductase TmpR	-
TO73_RS13560 (TO73_1935)	-	1757451..1757900 (-)	450	WP_040684680.1	hypothetical protein	-
TO73_RS13830 (TO73_1936)	-	1757921..1758475 (-)	555	WP_003049373.1	transposase family protein	-
TO73_RS13055	-	1758573..1759414 (-)	842	Protein_1864	IS5 family transposase	-
TO73_RS09335 (TO73_1940)	clpC	1759700..1762264 (+)	2565	WP_003049377.1	ATP-dependent chaperone ClpB	Regulator
TO73_RS09340 (TO73_1941)	-	1762274..1762663 (+)	390	WP_003049379.1	ferritin family protein	-
TO73_RS09345 (TO73_1942)	-	1762660..1763844 (+)	1185	WP_003049381.1	VLRF1 family aeRF1-type release factor	-
TO73_RS09350 (TO73_1943)	-	1763859..1764272 (+)	414	WP_003049384.1	Hsp20/alpha crystallin family protein	-
TO73_RS09355 (TO73_1944)	-	1764285..1764971 (+)	687	WP_003049387.1	hypothetical protein	-
TO73_RS09360 (TO73_1945)	trxA	1765093..1765512 (+)	420	WP_003049390.1	thioredoxin	-
TO73_RS09365 (TO73_1946)	-	1765525..1765938 (+)	414	WP_003049394.1	Hsp20/alpha crystallin family protein	-
TO73_RS09370 (TO73_1947)	-	1766128..1766574 (+)	447	WP_003049397.1	DUF1931 family protein	-
TO73_RS09375 (TO73_1948)	-	1766576..1766995 (+)	420	WP_003049401.1	phosphate-starvation-inducible PsiE family protein	-

Sequence

Protein

• Length: 854 a.a.
• Molecular weight: 95954.52 Da
• Isoelectric Point: 5.6415

>NTDB_id=124684 TO73_RS09335 WP_003049377.1 1759700..1762264(+) (clpC) [Thermus aquaticus Y51MC23]
MNLERWTQAAREALAQAQVLARKLQHQAIDTPHLWAVLLRDPGGLPWRLLEKAGADPKALKELMERELSRLPKVEGAEGG
QYLTARLSGVFNRAEALMEELKDRFVALDTLVLALAEATPGLPGLEPLKRALLELRGGKTVQTEHAESTYNALEQYGIDL
TALAAQGKLDPVIGRDEEIRRTIQILLRRTKNNPVLIGEPGVGKTAIVEGLAQRIVKGDVPEGLKGKRIISLQMGSLLAG
AKYRGEFEERLKAVIQEVVASQGEIILFIDEIHTVVGAGKAEGAVDAGNMLKPALARGELRLIGATTLDEYREIEKDPAL
ERRFQPVYVEEPSVEDTISILRGIKEKYEVHHGVRISDPALVAAAVLSHRYITERRLPDKAIDLIDEAAARLRMALESAP
EEIDTLERKKLQLEIEREALKKEKDPDSLERLKAIEAEIAELTKEIEKLKAEWEAEREILKKLREAQHRLDEVRREIELA
ERHYDLNRAAELRYGELPRLEAEVEALSEKLKNARFVRLEVTEEDIAEIVSRWTGIPVAKLLEGEREKLLRLEEELHKRV
VGQDEAIRAVADAIRRARAGLKDPNRPIGSFLFLGPTGVGKTELAKTLAATLFDTEEAMVRIDMTEYMEKHAVSRLIGAP
PGYVGYEEGGQLTEAVRRRPYSVILFDEIEKAHPDVFNILLQILDDGRLTDSHGRTVDFRNTVIILTSNLGSPLILEGIQ
KGLPYERIRDEVFGVLQKHFRPEFLNRLDEIVVFRPLSREQIRQIVDIQLANLRARLSEKRITLELSEAAKDFLAQRGYD
PVFGARPLKRVIQRELETPLAKKILAGEIKEGDRVLVDVGLEGLSFRAAERISA

Nucleotide

• Length: 2565 bp

>NTDB_id=124684 TO73_RS09335 WP_003049377.1 1759700..1762264(+) (clpC) [Thermus aquaticus Y51MC23]
ATGAACCTGGAACGCTGGACCCAAGCCGCCCGCGAAGCCCTGGCCCAGGCCCAGGTCCTGGCCCGGAAGCTTCAGCACCA
GGCCATAGACACCCCCCACCTCTGGGCCGTCCTGCTGAGGGACCCTGGGGGGCTTCCCTGGCGGCTTTTGGAGAAGGCCG
GGGCCGACCCCAAGGCCCTGAAGGAGCTCATGGAGCGGGAGCTTTCCCGCCTCCCCAAGGTGGAGGGGGCCGAGGGCGGG
CAGTACCTGACGGCCCGGCTTTCCGGGGTCTTTAACCGGGCCGAGGCCCTGATGGAGGAGCTCAAGGACCGCTTCGTGGC
CCTGGACACCCTGGTCCTGGCCTTGGCCGAGGCCACCCCGGGCCTTCCCGGCCTCGAGCCCCTGAAACGAGCCCTTTTGG
AACTCAGAGGAGGTAAGACCGTGCAGACGGAACACGCGGAGAGCACCTACAACGCTTTGGAGCAATACGGCATTGACCTG
ACGGCCTTGGCCGCCCAGGGCAAGCTGGACCCGGTCATCGGCCGGGACGAGGAGATCCGGCGCACCATCCAGATCCTCCT
CCGGCGCACCAAGAACAACCCGGTCCTGATCGGCGAGCCCGGCGTGGGCAAGACGGCCATCGTGGAGGGCCTCGCCCAGC
GCATCGTCAAAGGGGACGTGCCCGAGGGCCTCAAGGGCAAGCGCATCATCTCCTTGCAGATGGGCTCCCTCTTGGCCGGG
GCCAAGTACCGGGGCGAGTTTGAGGAGCGCCTGAAGGCGGTCATCCAGGAGGTGGTGGCGAGCCAGGGGGAGATCATCCT
CTTCATTGACGAGATCCACACCGTGGTGGGCGCCGGCAAGGCCGAGGGGGCCGTGGACGCCGGCAACATGCTGAAGCCCG
CCCTGGCCCGCGGGGAGCTCAGGCTCATCGGGGCCACCACCTTGGACGAGTACCGGGAGATTGAGAAGGACCCCGCCCTG
GAGAGGCGCTTCCAGCCCGTCTACGTGGAAGAGCCCAGCGTGGAGGACACCATCTCCATCCTGCGGGGCATCAAGGAGAA
GTACGAGGTCCACCACGGGGTGCGCATCTCCGACCCCGCCCTGGTGGCGGCGGCGGTTCTCTCCCACCGCTACATCACGG
AAAGGCGCCTCCCCGACAAGGCCATTGACCTCATTGACGAGGCGGCGGCCAGGCTCCGCATGGCCTTGGAGAGCGCTCCC
GAGGAGATAGACACCCTGGAGCGCAAGAAGCTCCAGCTGGAGATTGAGCGGGAAGCCCTGAAGAAGGAGAAGGACCCAGA
CTCCCTAGAGCGCCTCAAGGCCATTGAGGCCGAGATCGCCGAGCTCACCAAGGAGATTGAGAAGCTCAAGGCCGAGTGGG
AGGCCGAGAGGGAGATCCTGAAGAAGCTCCGCGAGGCCCAGCACCGCCTGGACGAGGTGAGGCGGGAGATTGAGCTGGCC
GAGCGCCACTACGACCTGAACCGGGCCGCCGAGCTCCGCTACGGGGAGCTTCCCCGCCTCGAGGCCGAGGTGGAGGCCCT
CTCCGAGAAGCTCAAGAACGCCCGCTTCGTCCGCCTGGAGGTCACCGAGGAGGACATCGCCGAGATCGTCTCCCGCTGGA
CGGGGATCCCCGTGGCCAAGCTCCTGGAAGGCGAGCGGGAGAAGCTCCTGAGGCTTGAGGAGGAGCTCCACAAGCGGGTG
GTGGGGCAGGACGAGGCCATAAGGGCCGTGGCCGATGCCATCCGCCGCGCCCGGGCCGGCCTCAAGGACCCGAACCGCCC
CATCGGGAGCTTCCTCTTCCTAGGCCCCACGGGCGTGGGCAAAACCGAGCTGGCCAAGACCCTGGCTGCCACCCTCTTTG
ACACCGAGGAGGCCATGGTCCGCATTGACATGACGGAGTACATGGAGAAGCACGCCGTCAGCCGCCTCATCGGGGCCCCT
CCCGGCTACGTGGGCTACGAGGAAGGGGGCCAGCTCACCGAGGCCGTCCGCCGGCGGCCCTACAGCGTCATCCTCTTTGA
CGAGATTGAGAAGGCCCACCCCGACGTCTTCAACATCCTCCTGCAGATCCTGGACGACGGCCGCCTCACCGACAGCCACG
GGCGCACCGTGGACTTCCGCAACACCGTCATCATCCTGACCTCCAACCTGGGTAGCCCCCTCATCCTGGAGGGCATCCAG
AAGGGTCTGCCCTACGAGCGGATCCGCGACGAGGTCTTCGGCGTCCTGCAGAAGCACTTCCGCCCCGAGTTCCTGAACCG
GCTGGACGAGATCGTGGTCTTCCGGCCCCTCTCCCGGGAGCAGATCCGCCAGATCGTGGACATCCAGCTCGCCAACCTCC
GGGCGAGGCTTTCGGAAAAGCGGATCACCCTGGAACTCAGCGAGGCCGCCAAGGACTTCCTGGCCCAAAGGGGCTACGAC
CCCGTCTTCGGCGCCAGGCCCCTGAAGCGGGTCATCCAGCGGGAGCTGGAGACCCCCCTGGCCAAGAAGATCCTGGCCGG
GGAGATCAAGGAGGGGGACCGGGTCCTGGTGGACGTGGGCCTCGAGGGCCTCTCCTTCCGCGCCGCCGAGCGCATCTCGG
CCTGA

Domains

Predicted by InterProScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (195-325)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-68)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (757-837)

• AAA lid domain (AAA_lid_9) (333-435)

• AAA domain (Cdc48 subfamily) (AAA_2) (586-751)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	46.636	100	0.471
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	42.907	100	0.436
clpE	Streptococcus mutans UA159	49.926	79.508	0.397
clpC	Lactococcus lactis subsp. cremoris KW2	49.199	80.445	0.396
clpE	Streptococcus pneumoniae R6	48.837	80.562	0.393
clpE	Streptococcus pneumoniae Rx1	48.837	80.562	0.393
clpE	Streptococcus pneumoniae D39	48.837	80.562	0.393
clpE	Streptococcus pneumoniae TIGR4	48.547	80.562	0.391