Detailed information NTG0124137

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SP5448_RS03135
• Genome accession: NZ_CP008776
• Coordinates: 617105..618142 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 5448
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 612105..623142

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP5448_RS03110 (SP5448_03230)	-	612369..613700 (+)	1332	WP_011285641.1	dipeptidase	-
SP5448_RS03115 (SP5448_03235)	arcC	613720..614670 (+)	951	WP_010922501.1	carbamate kinase	-
SP5448_RS03120 (SP5448_03240)	asnA	614983..615975 (+)	993	WP_010922500.1	aspartate--ammonia ligase	-
SP5448_RS03125 (SP5448_03245)	rsmD	616098..616637 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SP5448_RS03130 (SP5448_03250)	coaD	616627..617118 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
SP5448_RS03135 (SP5448_03255)	sepM	617105..618142 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
SP5448_RS03140 (SP5448_03260)	-	618556..619532 (+)	977	Protein_575	LacI family DNA-binding transcriptional regulator	-
SP5448_RS03145 (SP5448_03265)	-	619980..620600 (+)	621	WP_011285637.1	YutD family protein	-
SP5448_RS03150 (SP5448_03270)	rlmN	620604..621683 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
SP5448_RS03155 (SP5448_03275)	-	621765..622391 (-)	627	WP_010922497.1	A24 family peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=124137 SP5448_RS03135 WP_010922499.1 617105..618142(+) (sepM) [Streptococcus pyogenes strain 5448]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=124137 SP5448_RS03135 WP_010922499.1 617105..618142(+) (sepM) [Streptococcus pyogenes strain 5448]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693