Detailed information NTG0122445

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ER12_RS10055
• Genome accession: NZ_CP007676
• Coordinates: 1996351..1997394 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain HUV05
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1991351..2002394

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ER12_RS10025 (ER12_009500)	-	1991769..1993025 (-)	1257	WP_001795438.1	aminopeptidase	-
ER12_RS10030 (ER12_009505)	-	1993028..1993228 (-)	201	WP_000180461.1	DUF1128 family protein	-
ER12_RS10035 (ER12_009510)	-	1993375..1993839 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ER12_RS10040 (ER12_009515)	-	1993846..1994121 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ER12_RS10045 (ER12_009520)	-	1994399..1995616 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
ER12_RS10050 (ER12_009525)	vraR	1995732..1996361 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
ER12_RS10055 (ER12_009530)	vraS	1996351..1997394 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ER12_RS10060 (ER12_009535)	liaF	1997391..1998092 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ER12_RS10065 (ER12_009540)	-	1998107..1998493 (-)	387	WP_001110179.1	hypothetical protein	-
ER12_RS10070 (ER12_009545)	map	1998710..1999468 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ER12_RS10080 (ER12_009550)	-	1999996..2000982 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
ER12_RS10085 (ER12_009555)	-	2001413..2001826 (-)	414	WP_001549145.1	hypothetical protein	-
ER12_RS10090	-	2001855..2001965 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=122445 ER12_RS10055 WP_001017131.1 1996351..1997394(-) (vraS) [Staphylococcus aureus strain HUV05]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=122445 ER12_RS10055 WP_001017131.1 1996351..1997394(-) (vraS) [Staphylococcus aureus strain HUV05]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1