Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   ER12_RS00200 Genome accession   NZ_CP007676
Coordinates   47992..49341 (-) Length   449 a.a.
NCBI ID   WP_048520823.1    Uniprot ID   -
Organism   Staphylococcus aureus strain HUV05     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 39577..54506 47992..49341 within 0


Gene organization within MGE regions


Location: 39577..54506
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ER12_RS00160 (ER12_000160) mecA 39577..41586 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  ER12_RS00165 (ER12_000165) - 41683..42669 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  ER12_RS00170 (ER12_000170) - 42641..42901 (+) 261 WP_001549961.1 type I restriction enzyme endonuclease domain-containing protein -
  ER12_RS00175 (ER12_000175) - 42892..44499 (-) 1608 Protein_32 IS1182 family transposase -
  ER12_RS00180 (ER12_000180) - 44551..45057 (-) 507 WP_001092189.1 DUF1643 domain-containing protein -
  ER12_RS00185 (ER12_000185) - 45072..45383 (-) 312 WP_000700851.1 DUF960 family protein -
  ER12_RS00190 (ER12_000195) - 45470..45820 (-) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  ER12_RS00195 (ER12_000200) ccrB 46342..47970 (-) 1629 WP_001186608.1 recombinase family protein Machinery gene
  ER12_RS00200 (ER12_000205) ccrA 47992..49341 (-) 1350 WP_048520823.1 recombinase family protein Machinery gene
  ER12_RS00205 (ER12_000210) - 49575..51362 (-) 1788 WP_000122623.1 DUF927 domain-containing protein -
  ER12_RS00210 (ER12_000215) - 51362..51658 (-) 297 WP_002454339.1 single-stranded DNA-binding protein -
  ER12_RS00215 (ER12_000220) - 51851..52897 (-) 1047 WP_001042024.1 hypothetical protein -
  ER12_RS00220 (ER12_000225) - 53352..54506 (+) 1155 WP_000912116.1 ATP-binding protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52662.35 Da        Isoelectric Point: 10.0063

>NTDB_id=122413 ER12_RS00200 WP_048520823.1 47992..49341(-) (ccrA) [Staphylococcus aureus strain HUV05]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCNILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=122413 ER12_RS00200 WP_048520823.1 47992..49341(-) (ccrA) [Staphylococcus aureus strain HUV05]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTAACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)

Recombinase (Recombinase)

(169-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

97.327

100

0.973
  ccrA Staphylococcus aureus COL

75.724

100

0.757

Multiple sequence alignment