Detailed information NTG0122110

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ER16_RS09950
• Genome accession: NZ_CP007659
• Coordinates: 1990275..1991318 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain H-EMRSA-15
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1985275..1996318

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ER16_RS09920 (ER16_09495)	-	1985696..1986952 (-)	1257	WP_075583716.1	aminopeptidase	-
ER16_RS09925 (ER16_09500)	-	1986955..1987155 (-)	201	WP_000180460.1	DUF1128 family protein	-
ER16_RS09930 (ER16_09505)	-	1987302..1987766 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ER16_RS09935 (ER16_09510)	-	1987773..1988048 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ER16_RS09940 (ER16_09515)	-	1988326..1989543 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
ER16_RS09945 (ER16_09520)	vraR	1989656..1990285 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ER16_RS09950 (ER16_09525)	vraS	1990275..1991318 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ER16_RS09955 (ER16_09530)	liaF	1991315..1992016 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ER16_RS09960 (ER16_09535)	-	1992031..1992417 (-)	387	WP_001110179.1	hypothetical protein	-
ER16_RS09965 (ER16_09540)	map	1992634..1993392 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ER16_RS09970 (ER16_09545)	-	1993921..1994907 (+)	987	WP_000999713.1	FUSC family protein	-
ER16_RS09975 (ER16_09550)	-	1995338..1995751 (-)	414	WP_001670387.1	hypothetical protein	-
ER16_RS09980	-	1995780..1995890 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=122110 ER16_RS09950 WP_001017131.1 1990275..1991318(-) (vraS) [Staphylococcus aureus strain H-EMRSA-15]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=122110 ER16_RS09950 WP_001017131.1 1990275..1991318(-) (vraS) [Staphylococcus aureus strain H-EMRSA-15]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1