Detailed information NTG0122068

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EP20_RS09975
• Genome accession: NZ_CP007657
• Coordinates: 1985862..1986905 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain V2200
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1980862..1991905

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EP20_RS09945 (EP20_009485)	-	1981280..1982536 (-)	1257	WP_001795438.1	aminopeptidase	-
EP20_RS09950 (EP20_009490)	-	1982539..1982739 (-)	201	WP_000180461.1	DUF1128 family protein	-
EP20_RS09955 (EP20_009495)	-	1982886..1983350 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
EP20_RS09960 (EP20_009500)	-	1983357..1983632 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
EP20_RS09965 (EP20_009505)	-	1983910..1985127 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
EP20_RS09970 (EP20_009510)	vraR	1985243..1985872 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
EP20_RS09975 (EP20_009515)	vraS	1985862..1986905 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
EP20_RS09980 (EP20_009520)	liaF	1986902..1987603 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
EP20_RS09985 (EP20_009525)	-	1987618..1988004 (-)	387	WP_001110179.1	hypothetical protein	-
EP20_RS09990 (EP20_009530)	map	1988221..1988979 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
EP20_RS10000 (EP20_009535)	-	1989566..1990552 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
EP20_RS10005 (EP20_009540)	-	1991042..1991455 (-)	414	WP_001549145.1	hypothetical protein	-
EP20_RS10010	-	1991484..1991594 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=122068 EP20_RS09975 WP_001017131.1 1985862..1986905(-) (vraS) [Staphylococcus aureus strain V2200]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=122068 EP20_RS09975 WP_001017131.1 1985862..1986905(-) (vraS) [Staphylococcus aureus strain V2200]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1