Detailed information
Bioinformatically predicted
Overview
| Name | comB10 | Type | Machinery gene |
| Locus tag | EG65_RS02990 | Genome accession | NZ_CP007603 |
| Coordinates | 623477..624685 (-) | Length | 402 a.a. |
| NCBI ID | WP_026938138.1 | Uniprot ID | - |
| Organism | Helicobacter pylori J166 | ||
| Function | transformation-associated type IV transport system (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 524756..625507 | 623477..624685 | within | 0 |
Gene organization within MGE regions
Location: 524756..625507
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EG65_RS02550 (EG65_02665) | - | 525196..525876 (+) | 681 | WP_000401220.1 | F0F1 ATP synthase subunit A | - |
| EG65_RS02555 (EG65_02670) | - | 526203..526451 (+) | 249 | WP_000790557.1 | RNA-binding protein | - |
| EG65_RS02560 (EG65_02675) | - | 526671..527492 (-) | 822 | WP_026938416.1 | glycosyltransferase family 25 protein | - |
| EG65_RS02565 (EG65_02680) | trxB | 527843..528778 (-) | 936 | WP_000564420.1 | thioredoxin-disulfide reductase | - |
| EG65_RS02570 (EG65_02685) | trxA | 528784..529104 (-) | 321 | WP_000020199.1 | thioredoxin | - |
| EG65_RS02575 (EG65_02690) | - | 529193..529537 (-) | 345 | WP_001211718.1 | YraN family protein | - |
| EG65_RS02580 (EG65_02695) | - | 529538..530803 (-) | 1266 | WP_026938417.1 | homoserine dehydrogenase | - |
| EG65_RS02585 (EG65_02700) | uvrC | 530814..532598 (-) | 1785 | WP_026938418.1 | excinuclease ABC subunit UvrC | Machinery gene |
| EG65_RS02590 (EG65_02705) | - | 532599..533060 (-) | 462 | WP_000437213.1 | hypothetical protein | - |
| EG65_RS02595 (EG65_02710) | - | 533052..533231 (+) | 180 | WP_000468791.1 | hypothetical protein | - |
| EG65_RS02600 (EG65_02715) | - | 533228..533884 (-) | 657 | WP_026938419.1 | ATP-binding cassette domain-containing protein | - |
| EG65_RS02605 (EG65_02720) | - | 533886..535547 (-) | 1662 | WP_026938420.1 | ABC transporter permease/substrate-binding protein | - |
| EG65_RS02610 (EG65_02725) | - | 535616..536062 (-) | 447 | WP_001081241.1 | hypothetical protein | - |
| EG65_RS02615 (EG65_02730) | motB | 536059..536832 (-) | 774 | WP_026938421.1 | flagellar motor protein MotB | - |
| EG65_RS02620 (EG65_02735) | motA | 536835..537608 (-) | 774 | WP_000366185.1 | flagellar motor stator protein MotA | - |
| EG65_RS02625 (EG65_02740) | - | 537624..538391 (-) | 768 | WP_026938422.1 | HesA/MoeB/ThiF family protein | - |
| EG65_RS02630 (EG65_02745) | - | 538392..539006 (-) | 615 | WP_026938423.1 | MBL fold metallo-hydrolase | - |
| EG65_RS02635 (EG65_02750) | - | 539115..540149 (+) | 1035 | WP_187290092.1 | class I SAM-dependent methyltransferase | - |
| EG65_RS02640 (EG65_02755) | - | 540619..540954 (+) | 336 | WP_026938425.1 | hypothetical protein | - |
| EG65_RS02645 (EG65_02760) | rsmD | 540933..541535 (+) | 603 | WP_026938426.1 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| EG65_RS02650 (EG65_02765) | fliL | 541544..542095 (+) | 552 | WP_000797032.1 | flagellar basal body-associated protein FliL | - |
| EG65_RS02655 (EG65_02770) | acpS | 542102..542461 (+) | 360 | WP_026938427.1 | holo-ACP synthase | - |
| EG65_RS02660 (EG65_02775) | - | 542659..545040 (+) | 2382 | WP_026938428.1 | TonB-dependent receptor family protein | - |
| EG65_RS02665 (EG65_02780) | - | 545043..545663 (-) | 621 | WP_026938429.1 | M48 family metallopeptidase | - |
| EG65_RS02670 (EG65_02785) | - | 545745..546599 (+) | 855 | WP_026938430.1 | glycosyltransferase family 25 protein | - |
| EG65_RS02675 (EG65_02795) | - | 546770..547804 (+) | 1035 | WP_026938431.1 | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II | - |
| EG65_RS02680 (EG65_02800) | - | 547986..548732 (+) | 747 | WP_236620039.1 | DUF3943 domain-containing protein | - |
| EG65_RS02685 (EG65_02805) | ribA | 548821..549399 (+) | 579 | WP_001882183.1 | GTP cyclohydrolase II | - |
| EG65_RS02690 (EG65_02810) | - | 549471..549692 (+) | 222 | WP_026938433.1 | MoaD/ThiS family protein | - |
| EG65_RS02695 (EG65_02815) | - | 549693..550130 (+) | 438 | WP_026938434.1 | molybdopterin synthase catalytic subunit | - |
| EG65_RS02700 (EG65_02820) | mog | 550143..550673 (+) | 531 | WP_026938435.1 | molybdopterin adenylyltransferase | - |
| EG65_RS02705 (EG65_02825) | moaC | 550682..551158 (+) | 477 | WP_026938436.1 | cyclic pyranopterin monophosphate synthase MoaC | - |
| EG65_RS02710 (EG65_02830) | hpaA | 551277..552059 (+) | 783 | WP_026938437.1 | flagellar sheath lipoprotein HpaA | - |
| EG65_RS02715 (EG65_02835) | - | 552088..552924 (+) | 837 | WP_026938438.1 | outer membrane protein | - |
| EG65_RS02720 (EG65_02840) | tig | 553036..554391 (+) | 1356 | WP_026938439.1 | trigger factor | - |
| EG65_RS02725 (EG65_02845) | clpP | 554412..554999 (+) | 588 | WP_000540573.1 | ATP-dependent Clp endopeptidase proteolytic subunit ClpP | - |
| EG65_RS02730 (EG65_02850) | def | 555004..555528 (+) | 525 | WP_026938440.1 | peptide deformylase | - |
| EG65_RS02735 (EG65_02855) | - | 555534..557054 (+) | 1521 | WP_026938441.1 | YifB family Mg chelatase-like AAA ATPase | - |
| EG65_RS02740 (EG65_02860) | - | 557079..559139 (+) | 2061 | WP_026938442.1 | heavy metal translocating P-type ATPase | - |
| EG65_RS02745 (EG65_02865) | - | 559175..560466 (+) | 1292 | Protein_534 | restriction endonuclease subunit S | - |
| EG65_RS02755 (EG65_02875) | hofF | 560699..562198 (-) | 1500 | WP_026938111.1 | outer membrane beta-barrel protein HofF | - |
| EG65_RS02760 (EG65_02880) | - | 562476..563708 (-) | 1233 | WP_026938112.1 | ABC transporter permease | - |
| EG65_RS02765 (EG65_02885) | secA | 563698..566295 (-) | 2598 | WP_026938113.1 | preprotein translocase subunit SecA | - |
| EG65_RS02770 (EG65_02890) | lolA | 566443..566997 (+) | 555 | WP_026938114.1 | LolA-like outer membrane lipoprotein chaperone | - |
| EG65_RS02780 (EG65_02895) | - | 567481..568008 (+) | 528 | WP_026938115.1 | hypothetical protein | - |
| EG65_RS02785 (EG65_02900) | - | 568015..569382 (-) | 1368 | WP_026938116.1 | outer membrane family protein | - |
| EG65_RS02790 (EG65_02905) | - | 569475..570764 (-) | 1290 | WP_026938117.1 | DDE transposase | - |
| EG65_RS08485 | - | 570792..570973 (-) | 182 | Protein_542 | hypothetical protein | - |
| EG65_RS02795 (EG65_02910) | - | 571029..571295 (-) | 267 | WP_026938118.1 | hypothetical protein | - |
| EG65_RS02800 (EG65_02915) | acnB | 571376..573934 (-) | 2559 | WP_026938119.1 | bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase | - |
| EG65_RS02805 (EG65_02920) | - | 574065..574748 (+) | 684 | WP_001210703.1 | MqnA/MqnD/SBP family protein | - |
| EG65_RS02810 (EG65_02925) | pyrH | 574858..575580 (+) | 723 | WP_001148056.1 | UMP kinase | - |
| EG65_RS02815 (EG65_02930) | - | 575624..575848 (+) | 225 | WP_000712202.1 | DNA-directed RNA polymerase subunit omega | - |
| EG65_RS02820 (EG65_02935) | - | 575835..578162 (+) | 2328 | WP_026938120.1 | RelA/SpoT family protein | - |
| EG65_RS02825 (EG65_02940) | tyrS | 578186..579394 (+) | 1209 | WP_000435645.1 | tyrosine--tRNA ligase | - |
| EG65_RS02830 (EG65_02945) | fabX | 579410..580501 (+) | 1092 | WP_000255230.1 | decanoate oxidase/trans-2-decenoyl-[acyl-carrier protein] isomerase FabX | - |
| EG65_RS02835 (EG65_02950) | - | 580508..581890 (+) | 1383 | WP_026938121.1 | N-acetylmuramoyl-L-alanine amidase family protein | - |
| EG65_RS02840 (EG65_02955) | - | 581909..582646 (+) | 738 | WP_026938122.1 | hypothetical protein | - |
| EG65_RS02845 (EG65_02960) | flhB | 582734..583810 (-) | 1077 | WP_026938123.1 | flagellar biosynthesis protein FlhB | - |
| EG65_RS02850 (EG65_02965) | mobA | 583803..584408 (-) | 606 | WP_026938124.1 | molybdenum cofactor guanylyltransferase MobA | - |
| EG65_RS02855 (EG65_02970) | moaA | 584495..585460 (+) | 966 | WP_033582001.1 | GTP 3',8-cyclase MoaA | - |
| EG65_RS02865 (EG65_02985) | - | 585716..587284 (+) | 1569 | WP_026938126.1 | hypothetical protein | - |
| EG65_RS02870 (EG65_02990) | - | 588197..590230 (+) | 2034 | WP_026938127.1 | relaxase/mobilization nuclease domain-containing protein | - |
| EG65_RS02875 (EG65_03005) | - | 591374..592441 (+) | 1068 | WP_026938128.1 | tyrosine-type recombinase/integrase | - |
| EG65_RS02880 (EG65_03010) | - | 592759..593547 (-) | 789 | WP_001106876.1 | Fic family protein | - |
| EG65_RS02885 (EG65_03015) | - | 593670..594353 (-) | 684 | WP_001153441.1 | hypothetical protein | - |
| EG65_RS02890 (EG65_03020) | - | 594574..595764 (+) | 1191 | WP_000636427.1 | hypothetical protein | - |
| EG65_RS02895 (EG65_03025) | - | 595771..597051 (-) | 1281 | WP_000737417.1 | hypothetical protein | - |
| EG65_RS02900 (EG65_03030) | - | 597063..598310 (-) | 1248 | WP_001162050.1 | type IV secretion system protein | - |
| EG65_RS02905 (EG65_03035) | - | 598310..599743 (-) | 1434 | WP_000323430.1 | hypothetical protein | - |
| EG65_RS02910 (EG65_03040) | - | 599753..601555 (-) | 1803 | WP_026938129.1 | hypothetical protein | - |
| EG65_RS02915 (EG65_03045) | - | 601555..602619 (-) | 1065 | WP_026938130.1 | ArdC family protein | - |
| EG65_RS08365 | - | 602616..602786 (-) | 171 | WP_000189769.1 | hypothetical protein | - |
| EG65_RS02925 (EG65_03065) | - | 603751..603945 (+) | 195 | WP_000095376.1 | hypothetical protein | - |
| EG65_RS02930 (EG65_03070) | - | 604398..605066 (+) | 669 | WP_026938131.1 | ParA family protein | - |
| EG65_RS02935 (EG65_03075) | - | 605107..605490 (+) | 384 | WP_000365694.1 | hypothetical protein | - |
| EG65_RS02940 (EG65_03085) | - | 605684..607747 (-) | 2064 | WP_026938132.1 | type IA DNA topoisomerase | - |
| EG65_RS02945 (EG65_03090) | - | 607737..607955 (-) | 219 | WP_001105128.1 | hypothetical protein | - |
| EG65_RS02955 (EG65_03100) | - | 608283..616250 (-) | 7968 | WP_026938133.1 | SNF2-related protein | - |
| EG65_RS02960 (EG65_03105) | - | 616270..618531 (-) | 2262 | WP_026938134.1 | type IV secretory system conjugative DNA transfer family protein | - |
| EG65_RS02965 (EG65_03110) | - | 618528..619046 (-) | 519 | WP_000760568.1 | hypothetical protein | - |
| EG65_RS02970 (EG65_03115) | - | 619043..619987 (-) | 945 | WP_026938135.1 | ATPase, T2SS/T4P/T4SS family | - |
| EG65_RS02975 (EG65_03120) | - | 619992..620267 (-) | 276 | WP_001278755.1 | hypothetical protein | - |
| EG65_RS02980 (EG65_03125) | - | 620284..621255 (-) | 972 | WP_026938136.1 | membrane protein | - |
| EG65_RS02985 (EG65_03130) | - | 621268..623493 (-) | 2226 | WP_026938137.1 | RGS domain-containing GTPase-activating protein | - |
| EG65_RS02990 (EG65_03135) | comB10 | 623477..624685 (-) | 1209 | WP_026938138.1 | DNA type IV secretion system protein ComB10 | Machinery gene |
Sequence
Protein
Download Length: 402 a.a. Molecular weight: 44934.52 Da Isoelectric Point: 9.9834
>NTDB_id=121549 EG65_RS02990 WP_026938138.1 623477..624685(-) (comB10) [Helicobacter pylori J166]
MKQSLLKKIGLGVGGFVVLMALGLLANKGSNNNNKEEIFQVSESKFPLSDYFFEEVKEEPKEKAKETPEVTTQEPTTQTS
PNPSVSANPNIKDYSHLNNNLNQQNNTITHLQQVLQSPSKIKPKPKHTKEQLEFLNTRLKPLEPTKPATKPETEYGVDSF
TNLKYKDIGTNEHKLLRTITADRMIPAFLITPISSQIAGKVTAQVESDIFASMGRAVLIPKGSKVIGYYNNNNQIGQYRL
NIAWTRIITPQGINIMLTNARGADVKGYNGLIGKYISRNFQRYGIPLLTNTLSNGLLIGITSALANNQNKKGDGNPFFGD
YLLMQLTRNTGMGINQVINQMLRQYGAQNPIIIIREGSRVFISPNLDIFIPKPKDGEVLAEFFKEKKPLIKTKEEVNNEE
EI
MKQSLLKKIGLGVGGFVVLMALGLLANKGSNNNNKEEIFQVSESKFPLSDYFFEEVKEEPKEKAKETPEVTTQEPTTQTS
PNPSVSANPNIKDYSHLNNNLNQQNNTITHLQQVLQSPSKIKPKPKHTKEQLEFLNTRLKPLEPTKPATKPETEYGVDSF
TNLKYKDIGTNEHKLLRTITADRMIPAFLITPISSQIAGKVTAQVESDIFASMGRAVLIPKGSKVIGYYNNNNQIGQYRL
NIAWTRIITPQGINIMLTNARGADVKGYNGLIGKYISRNFQRYGIPLLTNTLSNGLLIGITSALANNQNKKGDGNPFFGD
YLLMQLTRNTGMGINQVINQMLRQYGAQNPIIIIREGSRVFISPNLDIFIPKPKDGEVLAEFFKEKKPLIKTKEEVNNEE
EI
Nucleotide
Download Length: 1209 bp
>NTDB_id=121549 EG65_RS02990 WP_026938138.1 623477..624685(-) (comB10) [Helicobacter pylori J166]
ATGAAACAATCCTTGCTTAAAAAGATAGGCTTAGGTGTTGGGGGCTTTGTTGTTTTAATGGCATTAGGATTGCTTGCTAA
TAAAGGCTCAAACAATAACAATAAAGAAGAAATCTTTCAAGTAAGTGAGAGTAAATTCCCTTTAAGTGATTATTTCTTTG
AAGAAGTCAAAGAAGAGCCAAAAGAAAAAGCCAAAGAAACACCAGAAGTAACTACCCAAGAGCCTACAACACAAACTAGC
CCCAATCCTAGTGTTTCAGCTAATCCTAACATTAAAGATTATAGTCATCTTAACAACAATCTTAATCAGCAAAATAATAC
TATCACGCATTTACAACAAGTTTTACAAAGCCCCTCTAAAATAAAGCCTAAACCAAAGCATACTAAAGAGCAATTAGAAT
TTTTAAACACACGCCTTAAACCTTTAGAACCAACTAAACCAGCCACTAAGCCTGAGACGGAATACGGCGTGGATAGTTTT
ACTAATTTAAAATATAAAGACATCGGCACTAATGAGCATAAGCTTTTAAGAACCATAACCGCTGATAGAATGATACCAGC
CTTTTTAATCACGCCTATTAGCTCTCAAATTGCTGGAAAAGTAACCGCCCAAGTAGAGAGCGATATATTTGCAAGTATGG
GTAGAGCGGTGCTAATCCCTAAAGGCTCTAAGGTCATAGGCTATTACAATAATAACAATCAAATTGGACAATACCGCTTA
AACATTGCTTGGACTAGAATTATCACCCCTCAAGGCATAAATATCATGCTCACTAATGCAAGAGGGGCTGATGTGAAAGG
CTATAATGGCTTAATAGGCAAATACATTAGCCGAAATTTTCAACGCTATGGTATCCCCTTACTCACTAACACGCTTTCTA
ATGGGCTTTTAATAGGAATTACTTCAGCCTTAGCTAATAACCAAAACAAAAAAGGTGATGGCAACCCTTTTTTTGGGGAT
TATTTGCTTATGCAACTCACTAGAAACACAGGCATGGGGATTAACCAAGTCATCAATCAAATGCTAAGACAATATGGAGC
GCAAAACCCCATTATCATCATTAGAGAGGGGAGCAGAGTATTTATTAGCCCTAATTTAGACATTTTTATCCCTAAACCAA
AAGATGGGGAGGTTCTAGCGGAGTTTTTTAAAGAGAAAAAACCCCTAATCAAAACAAAAGAGGAAGTTAACAATGAAGAA
GAAATCTAA
ATGAAACAATCCTTGCTTAAAAAGATAGGCTTAGGTGTTGGGGGCTTTGTTGTTTTAATGGCATTAGGATTGCTTGCTAA
TAAAGGCTCAAACAATAACAATAAAGAAGAAATCTTTCAAGTAAGTGAGAGTAAATTCCCTTTAAGTGATTATTTCTTTG
AAGAAGTCAAAGAAGAGCCAAAAGAAAAAGCCAAAGAAACACCAGAAGTAACTACCCAAGAGCCTACAACACAAACTAGC
CCCAATCCTAGTGTTTCAGCTAATCCTAACATTAAAGATTATAGTCATCTTAACAACAATCTTAATCAGCAAAATAATAC
TATCACGCATTTACAACAAGTTTTACAAAGCCCCTCTAAAATAAAGCCTAAACCAAAGCATACTAAAGAGCAATTAGAAT
TTTTAAACACACGCCTTAAACCTTTAGAACCAACTAAACCAGCCACTAAGCCTGAGACGGAATACGGCGTGGATAGTTTT
ACTAATTTAAAATATAAAGACATCGGCACTAATGAGCATAAGCTTTTAAGAACCATAACCGCTGATAGAATGATACCAGC
CTTTTTAATCACGCCTATTAGCTCTCAAATTGCTGGAAAAGTAACCGCCCAAGTAGAGAGCGATATATTTGCAAGTATGG
GTAGAGCGGTGCTAATCCCTAAAGGCTCTAAGGTCATAGGCTATTACAATAATAACAATCAAATTGGACAATACCGCTTA
AACATTGCTTGGACTAGAATTATCACCCCTCAAGGCATAAATATCATGCTCACTAATGCAAGAGGGGCTGATGTGAAAGG
CTATAATGGCTTAATAGGCAAATACATTAGCCGAAATTTTCAACGCTATGGTATCCCCTTACTCACTAACACGCTTTCTA
ATGGGCTTTTAATAGGAATTACTTCAGCCTTAGCTAATAACCAAAACAAAAAAGGTGATGGCAACCCTTTTTTTGGGGAT
TATTTGCTTATGCAACTCACTAGAAACACAGGCATGGGGATTAACCAAGTCATCAATCAAATGCTAAGACAATATGGAGC
GCAAAACCCCATTATCATCATTAGAGAGGGGAGCAGAGTATTTATTAGCCCTAATTTAGACATTTTTATCCCTAAACCAA
AAGATGGGGAGGTTCTAGCGGAGTTTTTTAAAGAGAAAAAACCCCTAATCAAAACAAAAGAGGAAGTTAACAATGAAGAA
GAAATCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comB10 | Helicobacter pylori P1 |
52.284 |
98.01 |
0.512 |