Detailed information NTG0121149

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: DX05_RS02970
• Genome accession: NZ_CP007572
• Coordinates: 535090..537351 (-)
• Length: 753 a.a.
• NCBI ID: WP_000882544.1
• Uniprot ID: X5KCK2
• Organism: Streptococcus agalactiae strain GBS6
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 530090..542351

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DX05_RS02950 (DX05_03000)	-	530166..530936 (+)	771	WP_001131467.1	DivIVA domain-containing protein	-
DX05_RS02955 (DX05_03005)	ileS	531221..534013 (+)	2793	WP_000768156.1	isoleucine--tRNA ligase	-
DX05_RS02960 (DX05_03010)	-	534083..534385 (-)	303	WP_001237037.1	DUF1827 family protein	-
DX05_RS02965 (DX05_03015)	-	534449..534904 (-)	456	WP_000184290.1	NUDIX hydrolase	-
DX05_RS02970 (DX05_03020)	clpE	535090..537351 (-)	2262	WP_000882544.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
DX05_RS02975 (DX05_03025)	-	537649..537879 (+)	231	WP_000443582.1	DUF1797 family protein	-
DX05_RS02980 (DX05_03030)	-	538022..538714 (+)	693	WP_001011648.1	ABC transporter permease subunit	-
DX05_RS02985 (DX05_03035)	-	538707..539441 (+)	735	WP_000230129.1	amino acid ABC transporter ATP-binding protein	-
DX05_RS02990 (DX05_03040)	-	539728..541422 (+)	1695	WP_001106848.1	phospho-sugar mutase	-

Sequence

Protein

• Length: 753 a.a.
• Molecular weight: 83774.98 Da
• Isoelectric Point: 5.2771

>NTDB_id=121149 DX05_RS02970 WP_000882544.1 535090..537351(-) (clpE) [Streptococcus agalactiae strain GBS6]
MLCQNCKLNESTIHLYTNVNGKQKQVDLCQNCYQIIKTDPNNPLFSGLNHVSHAPGGINPFFDDFFGDLNNFRAFNGQDL
PNTPPTQAGGNRGGGNGNGRNNNRNQTATPPQAKGILEEFGINVTEIARHGDIDPVIGRDSEIIRVIEILNRRTKNNPVL
IGEPGVGKTAVVEGLAQKIVDGNVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRQDVILFIDEIHEIVG
AGTAGEGSMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQKKYEDYHHVKY
NNDAIEAAAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDQRLIEAENLKAQATREEDYERAAYFRDQIAK
YKEMQQQKVDDQDTPIITEKTIEHIIEEKTNIPVGDLKEKEQSQLINLADDLKQHVIGQDDAVIKIAKAIRRNRVGLGSP
NRPIGSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLI
LLDEIEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGSGKTEASVGFGASREGRTNSVLGQLGNFFSPEF
MNRFDGIIEFKALDKENLLNIVDIMLSDVNARLAINGIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQEHIEDAITDYY
LENPSEKELRAIMTSNGNIIIKSSKKTEESTKG

Nucleotide

• Length: 2262 bp

>NTDB_id=121149 DX05_RS02970 WP_000882544.1 535090..537351(-) (clpE) [Streptococcus agalactiae strain GBS6]
ATGCTCTGTCAAAACTGCAAACTAAACGAATCAACTATTCATTTGTATACAAATGTTAATGGAAAACAAAAGCAAGTTGA
TCTTTGTCAAAATTGCTACCAAATTATTAAAACTGACCCTAATAATCCACTTTTTTCAGGTTTAAATCATGTTTCACATG
CGCCTGGTGGCATCAATCCTTTCTTTGATGATTTCTTTGGAGATTTAAATAATTTCAGAGCCTTTAATGGCCAAGATTTA
CCAAACACTCCTCCTACACAAGCAGGAGGAAACCGAGGTGGAGGAAACGGTAATGGACGAAATAATAATCGCAACCAAAC
TGCAACTCCTCCTCAAGCCAAAGGGATTCTAGAAGAATTTGGTATCAATGTCACTGAAATAGCCCGCCATGGTGATATTG
ACCCTGTTATTGGACGTGACTCAGAAATTATTCGTGTTATCGAAATCCTTAATCGTCGTACAAAAAATAATCCTGTACTT
ATTGGCGAACCCGGCGTAGGGAAAACTGCCGTTGTTGAAGGACTTGCTCAGAAAATTGTTGATGGTAATGTGCCTCATAA
ACTTCAAGGCAAACAAGTTATTCGTTTGGATGTTGTGAGTCTAGTACAAGGAACGGGCATTCGTGGTCAATTTGAAGAAC
GCATGCAAAAGTTGATGGAAGAAATTCGTCAACGTCAAGATGTTATTCTATTCATAGATGAAATTCACGAAATAGTTGGA
GCTGGTACAGCTGGCGAAGGTAGTATGGATGCAGGTAATATTTTAAAACCTGCCCTTGCACGTGGAGAATTACAACTAGT
AGGTGCCACTACTCTCAATGAATATCGTATTATCGAAAAGGACGCTGCCTTAGAACGCCGTATGCAACCTGTAAAAGTCG
ATGAACCTTCTGTTGAAGAAACCATTACTATTTTGAAAGGTATCCAAAAAAAATACGAAGATTATCATCACGTAAAATAT
AATAATGATGCCATAGAAGCAGCTGCAGTACTATCTAATCGTTATATCCAAGACCGCTTTTTACCTGATAAAGCAATAGA
CTTATTAGATGAAGCTGGTTCTAAAATGAACCTAACACTAAATTTTGTTGATCCAAAAGAAATTGATCAACGTCTCATTG
AAGCAGAAAATTTAAAAGCGCAAGCGACTCGTGAAGAAGATTACGAACGTGCAGCTTACTTCCGTGACCAGATTGCAAAA
TATAAAGAAATGCAGCAACAAAAGGTCGACGATCAAGATACACCTATTATTACCGAAAAAACAATTGAGCACATCATTGA
AGAAAAAACGAATATCCCTGTTGGTGATTTAAAAGAAAAAGAACAATCTCAATTAATTAATCTCGCAGATGACTTGAAAC
AGCATGTGATCGGCCAGGATGACGCTGTCATTAAGATTGCAAAAGCTATTCGTCGTAATCGAGTTGGTCTTGGTAGCCCA
AACCGTCCTATTGGTTCCTTTTTATTTGTAGGACCAACCGGTGTTGGTAAAACTGAACTTTCTAAACAACTAGCAATTGA
GCTCTTTGGTTCAGCTGATAGTATGATTCGTTTTGATATGTCAGAGTACATGGAAAAGCATGCTGTTGCTAAATTAGTCG
GAGCGCCTCCAGGATACGTGGGATACGAGGAAGCTGGACAACTAACTGAAAAGGTTCGTCGAAATCCTTACTCGCTCATC
CTTCTAGATGAAATTGAAAAAGCTCATCCCGATGTCATGCATATGTTCTTGCAGGTCCTTGATGACGGTCGATTAACAGA
TGGACAAGGAAGAACTGTTAGTTTTAAAGATACCATTATCATCATGACCTCAAATGCTGGTTCTGGTAAAACTGAAGCAA
GTGTTGGCTTTGGTGCCTCACGAGAAGGTAGGACGAATTCCGTACTAGGTCAACTAGGTAACTTCTTCAGCCCTGAATTT
ATGAACCGCTTTGACGGTATTATTGAATTCAAGGCTTTAGATAAAGAGAATCTCCTCAATATCGTTGATATTATGTTATC
TGACGTTAATGCACGTCTCGCCATCAATGGTATTCATCTAGATGTCACTGATAAAGTGAAAGAAAAATTGGTTGATTTAG
GTTACGATCCCAAAATGGGAGCACGTCCATTACGTCGTACCATTCAAGAACATATTGAAGATGCTATCACAGATTACTAT
CTTGAGAATCCAAGCGAAAAAGAACTTCGTGCTATTATGACTAGCAATGGAAATATCATAATAAAATCTTCTAAAAAAAC
TGAGGAAAGTACAAAAGGTTGA

Domains

Predicted by InterproScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (159-276)

• AAA lid domain (AAA_lid_9) (297-394)

• AAA domain (Cdc48 subfamily) (AAA_2) (482-645)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (653-727)

3D structure

• AlphaFold DB: X5KCK2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	85.809	100	0.859
clpE	Streptococcus pneumoniae Rx1	85.447	99.469	0.85
clpE	Streptococcus pneumoniae D39	85.447	99.469	0.85
clpE	Streptococcus pneumoniae R6	85.447	99.469	0.85
clpE	Streptococcus pneumoniae TIGR4	85.314	99.469	0.849
clpC	Lactococcus lactis subsp. cremoris KW2	74.867	99.867	0.748
clpC	Bacillus subtilis subsp. subtilis str. 168	51.18	90.04	0.461
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.528	83.267	0.396
clpC	Streptococcus pneumoniae Rx1	47.003	84.197	0.396
clpC	Streptococcus pneumoniae D39	47.003	84.197	0.396
clpC	Streptococcus pneumoniae TIGR4	46.845	84.197	0.394
clpC	Streptococcus mutans UA159	47.03	82.736	0.389
clpC	Streptococcus thermophilus LMD-9	46.276	83.798	0.388
clpC	Streptococcus thermophilus LMG 18311	45.959	83.798	0.385