Detailed information NTG0121027

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DK41_RS00435
• Genome accession: NZ_CP007570
• Coordinates: 68930..69832 (+)
• Length: 300 a.a.
• NCBI ID: WP_000912098.1
• Uniprot ID: A0AAD2WWZ7
• Organism: Streptococcus agalactiae strain GBS1-NY
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 63930..74832

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DK41_RS00410 (DK41_00410)	-	64479..65651 (+)	1173	WP_001248533.1	hypothetical protein	-
DK41_RS00415 (DK41_00415)	-	65931..66302 (+)	372	WP_001872566.1	hypothetical protein	-
DK41_RS00420 (DK41_00420)	-	66269..66673 (+)	405	WP_223297811.1	DUF6261 family protein	-
DK41_RS00425 (DK41_00425)	-	66673..67482 (+)	810	WP_000982340.1	hypothetical protein	-
DK41_RS00430 (DK41_00430)	purB	67479..68777 (+)	1299	WP_000572889.1	adenylosuccinate lyase	-
DK41_RS00435 (DK41_00435)	comR	68930..69832 (+)	903	WP_000912098.1	helix-turn-helix domain-containing protein	Regulator
DK41_RS00440 (DK41_00440)	ruvB	70121..71119 (+)	999	WP_000196633.1	Holliday junction branch migration DNA helicase RuvB	-
DK41_RS00445 (DK41_00445)	-	71271..71708 (+)	438	WP_000754818.1	low molecular weight protein-tyrosine-phosphatase	-
DK41_RS00450 (DK41_00450)	-	71715..72095 (+)	381	WP_000787702.1	membrane protein	-
DK41_RS00455 (DK41_00455)	-	72092..73870 (+)	1779	WP_001220904.1	acyltransferase family protein	-

Sequence

Protein

• Length: 300 a.a.
• Molecular weight: 35606.08 Da
• Isoelectric Point: 6.5030

>NTDB_id=121027 DK41_RS00435 WP_000912098.1 68930..69832(+) (comR) [Streptococcus agalactiae strain GBS1-NY]
MLKHFGSKVRNLRVTRNITREDFCGDETELSVRQLARIESGQSIPNLTKAHYIAKQLNVKLDILTGGESLELPKRYKELK
YKLLRTPTYGDANRLAVREAYFDEIYEVFYEELPEDERLIIDCMQSKLDVHFSVNDNFGITILHDYFDQIKKKKEYTTND
FVMIDLYLLCFSINYGMKSLYSLENYHFIMSKLLEQDNLLPEDNFQLNNVLLNHVELAFQFKQKKYVQQIIHRSNAIMTE
IHDFQKRPILSLIEWKYLLIIEKDRTKAETCFKQSILFAELIGDLYLKGKLIEEWNKDLT

Nucleotide

• Length: 903 bp

>NTDB_id=121027 DK41_RS00435 WP_000912098.1 68930..69832(+) (comR) [Streptococcus agalactiae strain GBS1-NY]
ATGTTAAAACATTTTGGTAGTAAAGTAAGAAATTTGAGAGTAACTAGAAATATTACTCGCGAAGATTTTTGTGGTGATGA
AACTGAGTTATCTGTAAGACAATTAGCTAGGATTGAAAGTGGACAGTCAATTCCAAACTTGACTAAAGCTCACTACATAG
CTAAACAATTGAATGTAAAATTGGATATTTTAACAGGAGGAGAGAGCTTAGAATTACCTAAACGGTATAAAGAGTTGAAG
TACAAATTGTTGCGTACCCCGACTTACGGAGATGCTAATAGACTTGCAGTTAGAGAAGCATATTTTGATGAAATCTATGA
AGTATTTTATGAGGAGCTCCCAGAAGATGAAAGACTAATTATTGATTGTATGCAATCAAAATTAGATGTTCATTTTTCTG
TTAATGATAATTTTGGAATCACTATTTTACATGACTACTTTGATCAAATTAAGAAAAAAAAGGAATATACCACAAATGAT
TTTGTTATGATAGATTTATATTTACTTTGCTTTTCTATTAACTATGGAATGAAGAGCTTGTATTCTTTAGAGAACTATCA
TTTTATTATGTCAAAATTGTTAGAGCAAGATAATTTACTTCCTGAGGATAATTTTCAATTGAACAACGTTTTATTAAATC
ATGTCGAATTAGCTTTTCAATTTAAGCAGAAAAAATATGTACAGCAAATTATTCATAGAAGTAATGCTATTATGACAGAA
ATCCATGATTTTCAAAAAAGACCAATACTAAGCTTAATAGAGTGGAAATATTTATTAATTATTGAAAAAGATAGAACAAA
AGCAGAAACATGTTTTAAACAATCAATTCTATTTGCAGAGTTAATAGGTGATCTATATTTAAAAGGAAAATTAATAGAGG
AGTGGAATAAAGATTTAACATGA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-295)

• Helix-turn-helix (HTH_3) (10-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	59.375	96	0.57
comR	Streptococcus mutans UA159	52.174	99.667	0.52
comR	Streptococcus pyogenes MGAS8232	50.166	100	0.503
comR	Streptococcus pyogenes MGAS315	47.667	100	0.477
comR	Streptococcus suis P1/7	40.067	99	0.397
comR	Streptococcus suis 05ZYH33	40.067	99	0.397
comR	Streptococcus suis D9	36.184	100	0.367