Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | DK93_RS03190 | Genome accession | NZ_CP007562 |
| Coordinates | 640422..642227 (+) | Length | 601 a.a. |
| NCBI ID | WP_038431433.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain NGAS327 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 615429..662477 | 640422..642227 | within | 0 |
Gene organization within MGE regions
Location: 615429..662477
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DK93_RS03070 (DK93_03175) | - | 615481..616260 (+) | 780 | WP_014635570.1 | formate/nitrite transporter family protein | - |
| DK93_RS08965 (DK93_03180) | - | 616820..617002 (+) | 183 | WP_011888786.1 | penicillin-binding protein | - |
| DK93_RS03080 (DK93_03185) | recR | 617049..617645 (+) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| DK93_RS03085 (DK93_03190) | - | 617746..618792 (+) | 1047 | WP_002994369.1 | D-alanine--D-alanine ligase | - |
| DK93_RS03090 (DK93_03195) | - | 618991..620358 (+) | 1368 | WP_002994368.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| DK93_RS03095 (DK93_03200) | - | 620462..621157 (+) | 696 | WP_002994365.1 | TIGR02206 family membrane protein | - |
| DK93_RS03100 (DK93_03205) | - | 621405..622949 (+) | 1545 | WP_002989155.1 | peptide chain release factor 3 | - |
| DK93_RS03105 (DK93_03210) | - | 623256..624875 (+) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| DK93_RS03110 (DK93_03215) | - | 625002..627002 (+) | 2001 | WP_002994363.1 | potassium transporter Kup | - |
| DK93_RS03115 (DK93_03220) | - | 627026..627304 (-) | 279 | WP_002989164.1 | GIY-YIG nuclease family protein | - |
| DK93_RS03120 (DK93_03225) | - | 627294..628070 (-) | 777 | WP_002994360.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| DK93_RS03125 (DK93_03230) | - | 628188..628928 (+) | 741 | WP_047236118.1 | lysophospholipid acyltransferase family protein | - |
| DK93_RS03130 (DK93_03235) | - | 629128..629790 (+) | 663 | WP_002995626.1 | ComEA family DNA-binding protein | - |
| DK93_RS03135 (DK93_03240) | - | 629771..632014 (+) | 2244 | WP_002995623.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| DK93_RS03140 (DK93_03245) | holA | 632085..633125 (+) | 1041 | WP_011054659.1 | DNA polymerase III subunit delta | - |
| DK93_RS03145 (DK93_03250) | sodA | 633222..633827 (+) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| DK93_RS08970 (DK93_03255) | - | 633994..634227 (+) | 234 | WP_002983979.1 | hypothetical protein | - |
| DK93_RS08975 (DK93_03265) | - | 634387..635042 (+) | 656 | Protein_571 | serine hydrolase | - |
| DK93_RS03165 (DK93_03270) | - | 635156..636376 (-) | 1221 | WP_038431438.1 | DUF3114 domain-containing protein | - |
| DK93_RS03170 (DK93_03275) | queA | 636383..637411 (-) | 1029 | WP_002995782.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| DK93_RS03175 (DK93_03280) | nagB | 637613..638317 (+) | 705 | WP_002995779.1 | glucosamine-6-phosphate deaminase | - |
| DK93_RS03180 (DK93_03285) | - | 638436..639152 (+) | 717 | WP_038431436.1 | pseudouridine synthase | - |
| DK93_RS03185 (DK93_03290) | - | 639447..640409 (+) | 963 | WP_002983995.1 | competence protein CoiA | - |
| DK93_RS03190 (DK93_03295) | pepF | 640422..642227 (+) | 1806 | WP_038431433.1 | oligoendopeptidase F | Regulator |
| DK93_RS03195 (DK93_03300) | - | 642603..643799 (+) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| DK93_RS03200 (DK93_03305) | - | 643865..644572 (+) | 708 | WP_011017939.1 | O-methyltransferase | - |
| DK93_RS03205 (DK93_03310) | prsA | 644635..645690 (+) | 1056 | WP_011184661.1 | peptidylprolyl isomerase PrsA | - |
| DK93_RS03210 (DK93_03315) | alaS | 646077..648695 (+) | 2619 | WP_047236119.1 | alanine--tRNA ligase | - |
| DK93_RS03220 (DK93_03325) | - | 649056..649271 (+) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| DK93_RS03225 (DK93_03330) | - | 649268..650028 (+) | 761 | Protein_583 | DUF3169 family protein | - |
| DK93_RS03230 (DK93_03335) | - | 650047..650742 (+) | 696 | WP_002995750.1 | CPBP family intramembrane glutamic endopeptidase | - |
| DK93_RS08630 | - | 650834..651991 (-) | 1158 | Protein_585 | IS3 family transposase | - |
| DK93_RS03250 (DK93_03355) | - | 652087..653313 (-) | 1227 | WP_002993437.1 | chloride channel protein | - |
| DK93_RS03255 (DK93_03360) | nrdF | 653375..654334 (-) | 960 | WP_002993434.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| DK93_RS03260 (DK93_03365) | nrdE | 654667..656826 (-) | 2160 | WP_002993430.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| DK93_RS03265 (DK93_03370) | - | 656846..657064 (-) | 219 | WP_002989242.1 | redoxin NrdH | - |
| DK93_RS03270 (DK93_03375) | - | 657457..657720 (+) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| DK93_RS03275 (DK93_03380) | ptsP | 657725..659458 (+) | 1734 | WP_020837320.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| DK93_RS03280 (DK93_03385) | - | 659643..661070 (+) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| DK93_RS03285 (DK93_03390) | - | 661165..662439 (+) | 1275 | WP_020837316.1 | polysaccharide deacetylase family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69426.36 Da Isoelectric Point: 4.7090
>NTDB_id=120944 DK93_RS03190 WP_038431433.1 640422..642227(+) (pepF) [Streptococcus pyogenes strain NGAS327]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=120944 DK93_RS03190 WP_038431433.1 640422..642227(+) (pepF) [Streptococcus pyogenes strain NGAS327]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
70.715 |
100 |
0.707 |