Detailed information NTG0118093

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: STAB904_RS06040
• Genome accession: NZ_CP007241
• Coordinates: 1211995..1213032 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 1E1
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1206995..1218032

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STAB904_RS06020 (STAB904_06750)	-	1207735..1208361 (+)	627	WP_038434165.1	prepilin peptidase	-
STAB904_RS06025 (STAB904_06755)	rlmN	1208443..1209522 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
STAB904_RS06030 (STAB904_06760)	-	1209526..1210146 (-)	621	WP_038434166.1	YutD family protein	-
STAB904_RS06035 (STAB904_06770)	-	1210594..1211571 (-)	978	WP_038434168.1	LacI family DNA-binding transcriptional regulator	-
STAB904_RS06040 (STAB904_06775)	sepM	1211995..1213032 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
STAB904_RS06045 (STAB904_06780)	coaD	1213019..1213510 (-)	492	WP_014407698.1	pantetheine-phosphate adenylyltransferase	-
STAB904_RS06050 (STAB904_06785)	rsmD	1213500..1214039 (-)	540	WP_038434169.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
STAB904_RS06055 (STAB904_06790)	asnA	1214162..1215154 (-)	993	WP_023611792.1	aspartate--ammonia ligase	-
STAB904_RS06060 (STAB904_06795)	arcC	1215467..1216417 (-)	951	WP_010922501.1	carbamate kinase	-
STAB904_RS06065 (STAB904_06800)	-	1216437..1217768 (-)	1332	WP_038434170.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=118093 STAB904_RS06040 WP_010922499.1 1211995..1213032(-) (sepM) [Streptococcus pyogenes strain 1E1]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=118093 STAB904_RS06040 WP_010922499.1 1211995..1213032(-) (sepM) [Streptococcus pyogenes strain 1E1]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693