Detailed information NTG0118041

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: STAB1101_RS05580
• Genome accession: NZ_CP007240
• Coordinates: 1123674..1124711 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 7F7
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1118674..1129711

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STAB1101_RS05560 (STAB1101_05560)	-	1119424..1120050 (+)	627	WP_002983834.1	prepilin peptidase	-
STAB1101_RS05565 (STAB1101_05565)	rlmN	1120132..1121211 (-)	1080	WP_038431459.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
STAB1101_RS05570 (STAB1101_05570)	-	1121215..1121835 (-)	621	WP_002992791.1	YutD family protein	-
STAB1101_RS05575 (STAB1101_05575)	-	1122283..1123260 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
STAB1101_RS05580 (STAB1101_05580)	sepM	1123674..1124711 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
STAB1101_RS05585 (STAB1101_05585)	coaD	1124698..1125189 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
STAB1101_RS05590 (STAB1101_05590)	rsmD	1125179..1125718 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
STAB1101_RS05595 (STAB1101_05595)	asnA	1125841..1126833 (-)	993	WP_002994813.1	aspartate--ammonia ligase	-
STAB1101_RS05600 (STAB1101_05600)	arcC	1127146..1128096 (-)	951	WP_002994815.1	carbamate kinase	-
STAB1101_RS05605 (STAB1101_05605)	-	1128116..1129447 (-)	1332	WP_011054719.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=118041 STAB1101_RS05580 WP_010922499.1 1123674..1124711(-) (sepM) [Streptococcus pyogenes strain 7F7]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=118041 STAB1101_RS05580 WP_010922499.1 1123674..1124711(-) (sepM) [Streptococcus pyogenes strain 7F7]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693