Detailed information NTG1170434

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: ACLV7W_RS03255
• Genome accession: NZ_OZ217346
• Coordinates: 670616..672874 (-)
• Length: 752 a.a.
• NCBI ID: WP_411865427.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis D22
• Function: degradation of ComX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	669161..670512	670616..672874	flank	104

Gene organization within MGE regions

Location: 669161..672874

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7W_RS03250	-	669161..670512 (+)	1352	WP_411865426.1	IS3 family transposase	-
ACLV7W_RS03255 (SMID22_06710)	clpE	670616..672874 (-)	2259	WP_411865427.1	ATP-dependent Clp protease ATP-binding subunit	Regulator

Sequence

Protein

• Length: 752 a.a.
• Molecular weight: 83760.21 Da
• Isoelectric Point: 5.4579

>NTDB_id=1170434 ACLV7W_RS03255 WP_411865427.1 670616..672874(-) (clpE) [Streptococcus mitis isolate S. mitis D22]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGITDLNNRDFDPFGDFFNDLNNFRPSSNTPPTPP
TQSGGGYGGNGGYGSQNRGPAQTPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
GDGNMDAGNILKPALARGELQLVGATTLNEYRVIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKVTDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAITDYYLENP
SEKDLKAVMTSKGKIQIKSAKKSEVKTSEKEK

Nucleotide

• Length: 2259 bp

>NTDB_id=1170434 ACLV7W_RS03255 WP_411865427.1 670616..672874(-) (clpE) [Streptococcus mitis isolate S. mitis D22]
ATGCTTTGTCAAAACTGTAAAATCAATGACTCAACAATTCATCTTTATACCAATCTCAATGGAAAGCAAAAACAAATTGA
CCTCTGTCAAAACTGCTATAAGATTATCAAGACAGATCCTAACAATAGCCTCTTTAAAGGTATAACTGATCTGAACAATC
GTGACTTTGATCCTTTCGGTGATTTCTTCAATGACCTAAATAATTTTAGACCTTCTAGCAATACTCCTCCGACTCCCCCA
ACCCAATCAGGTGGAGGTTACGGTGGAAATGGCGGTTATGGTTCCCAAAATCGTGGACCTGCTCAAACTCCTCCACCAAG
CCAAGAAAAAGGCCTACTGGAAGAATTTGGTATCAACGTAACTGAAATTGCCCGTCGTGGAGATATAGATCCCGTTATTG
GACGCGATGATGAGATTATCCGTGTCATTGAGATTCTCAATCGCAGAACCAAGAATAATCCTGTTCTTATCGGTGAACCT
GGTGTCGGAAAAACTGCCGTTGTCGAAGGTCTAGCTCAGAAAATCGTTGATGGTGATGTTCCACATAAACTCCAAGGCAA
ACAAGTCATCCGTCTGGATGTGGTTAGCTTGGTTCAAGGAACGGGTATTCGAGGACAATTTGAAGAACGCATGCAAAAAC
TCATGGAAGAAATTCGCAAACGTGAGGATATTATCCTCTTTATCGATGAAATCCATGAAATTGTCGGTGCTGGTTCTGCA
GGCGATGGCAATATGGATGCAGGAAATATCCTCAAGCCAGCCCTTGCTCGTGGGGAACTGCAACTGGTCGGTGCCACTAC
CCTCAATGAATACCGTGTCATTGAAAAGGATGCTGCCCTAGAGCGTCGTATGCAACCTGTCAAAGTCGATGAACCAACAG
TGGAAGAAACAATCACTATCCTCAAAGGCATTCAAAAGAAATACGAAGACTACCACCACGTTCAGTATACCGATGCTGCA
ATTGAAGCAGCTGCAACTCTGTCCAATCGCTACATCCAAGATCGCTTCTTGCCCGACAAGGCCATTGACCTCCTAGATGA
AGCGGGTTCTAAGATGAACTTGACCTTGAATTTTGTGGATCCTAAAGTGATTGATCAGCGCTTGATTGAGGCTGAAAATC
TCAAATCTCAAGCTACACGAGAGGAAGATTTTGAGAAGGCTGCCTACTTCCGCGACCAGATTGCCAAGTATAAGGAAATG
CAAAAGAAAAAGGTCACAGACCAAGATACTCCTATTATCAGTGAGAAAACCATTGAGCACATTATCGAGCAGAAAACCAA
CATTCCTGTTGGCGATTTGAAAGAGAAAGAACAATCTCAACTCATCCATCTAGCTGAAGACCTCAAGTCTCATGTTATTG
GACAGGACGATGCAGTTGATAAGATAGCCAAAGCTATTCGCCGTAATCGTGTCGGTCTCGGTACGCCTAACCGTCCAATT
GGAAGCTTCCTCTTTGTCGGACCAACTGGTGTCGGTAAGACAGAACTTTCCAAACAACTAGCTATCGAACTCTTTGGTTC
TGCTGACAGTATGATTCGCTTTGATATGAGTGAATATATGGAAAAACACAGTGTAGCTAAATTAGTTGGTGCCCCTCCAG
GTTATGTTGGCTACGATGAGGCTGGGCAATTAACTGAAAAAGTCCGGCGTAATCCCTACTCTCTTATTCTCTTAGATGAA
GTAGAGAAAGCTCATCCAGATGTCATGCATATGTTCCTTCAAGTCTTGGACGATGGTCGTTTAACAGATGGACAAGGACG
TACCGTCAGTTTTAAGGATGCCATTATTATCATGACTTCAAATGCTGGGACTGGTAAAGCCGAAGCCAGCGTTGGATTTG
GTGCTGCTAGAGAAGGACGTACCAATTCTGTTCTCGGTGAACTCGGTAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGTATTATCGAATTTAAGGCTCTCAGCAAGGACAACCTCCTTCAGATTGTCGAGCTTATGCTAGCAGACGTTAACAA
ACGTCTTTCAAGTAACAACATTCATTTAGATGTAACTGACAAGGTCAAGGAAAAATTAGTTGACCTCGGTTATGATCCAA
AAATGGGGGCACGCCCACTTCGTCGTACTATTCAAGACTATATTGAGGACGCAATCACTGACTACTACCTTGAAAATCCA
AGCGAAAAAGACCTCAAGGCAGTTATGACCAGCAAGGGCAAGATTCAAATTAAGTCTGCCAAAAAATCTGAAGTAAAAAC
TTCTGAAAAAGAAAAATAG

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (649-723)

• AAA lid domain (AAA_lid_9) (293-390)

• ATPase family associated with various cellular activities (AAA) (AAA) (155-274)

• AAA domain (Cdc48 subfamily) (AAA_2) (478-641)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus pneumoniae Rx1	98.138	100	0.981
clpE	Streptococcus pneumoniae D39	98.138	100	0.981
clpE	Streptococcus pneumoniae R6	98.138	100	0.981
clpE	Streptococcus pneumoniae TIGR4	98.005	100	0.98
clpE	Streptococcus mutans UA159	83.2	99.734	0.83
clpC	Lactococcus lactis subsp. cremoris KW2	75.198	100	0.758
clpC	Bacillus subtilis subsp. subtilis str. 168	50.43	92.819	0.468
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.847	83.378	0.399
clpC	Streptococcus pneumoniae Rx1	46.91	83.91	0.394
clpC	Streptococcus pneumoniae D39	46.91	83.91	0.394
clpC	Streptococcus pneumoniae TIGR4	46.91	83.91	0.394
clpC	Streptococcus mutans UA159	46.89	83.378	0.391
clpC	Streptococcus thermophilus LMD-9	46.795	82.979	0.388
clpC	Streptococcus thermophilus LMG 18311	46.4	83.112	0.386