Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   ACLV7Z_RS07290 Genome accession   NZ_OZ217343
Coordinates   1427553..1429811 (+) Length   752 a.a.
NCBI ID   WP_218773876.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis G22     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1422553..1434811
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7Z_RS07265 (SMIG22_14250) - 1423461..1424333 (-) 873 WP_218773879.1 NAD(P)H-hydrate dehydratase -
  ACLV7Z_RS07270 (SMIG22_14260) - 1424474..1425331 (-) 858 WP_218773878.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  ACLV7Z_RS07275 (SMIG22_14270) - 1425485..1426219 (-) 735 WP_218773877.1 amino acid ABC transporter ATP-binding protein -
  ACLV7Z_RS07280 (SMIG22_14280) - 1426219..1426902 (-) 684 WP_033676806.1 amino acid ABC transporter permease -
  ACLV7Z_RS07285 (SMIG22_14290) - 1427092..1427322 (+) 231 WP_000443574.1 DUF1797 family protein -
  ACLV7Z_RS07290 (SMIG22_14300) clpE 1427553..1429811 (+) 2259 WP_218773876.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  ACLV7Z_RS07295 (SMIG22_14310) - 1429942..1430394 (+) 453 WP_173275056.1 NUDIX hydrolase -
  ACLV7Z_RS07300 - 1430391..1430537 (-) 147 WP_225904863.1 hypothetical protein -
  ACLV7Z_RS07305 (SMIG22_14320) - 1430605..1430904 (+) 300 WP_000767194.1 DUF1827 family protein -
  ACLV7Z_RS07310 (SMIG22_14330) ezrA 1431087..1432814 (-) 1728 WP_057487212.1 septation ring formation regulator EzrA -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83792.35 Da        Isoelectric Point: 5.5418

>NTDB_id=1170216 ACLV7Z_RS07290 WP_218773876.1 1427553..1429811(+) (clpE) [Streptococcus mitis isolate S. mitis G22]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQSCYKIIKTDPNNSLFKGMTDLNNRDFDPFGDFFNDLNNFRPSSNTPPIPP
TQSGGGYGGNGGYGSQNHGSAQTPPPSQEKGLLEEFGINVTEIARRGGIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
SDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETIIILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKVTDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQIIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAITDYYLENP
SEKDLKAVMTSKGKIQIKYAKKAEVKTSEKEK

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=1170216 ACLV7Z_RS07290 WP_218773876.1 1427553..1429811(+) (clpE) [Streptococcus mitis isolate S. mitis G22]
ATGCTTTGTCAAAACTGTAAAATCAACGACTCAACAATTCATCTTTACACCAATCTCAATGGAAAGCAAAAACAAATTGA
CCTCTGTCAAAGCTGCTATAAGATTATCAAAACAGATCCTAACAACAGCCTCTTCAAAGGTATGACGGATCTAAATAATC
GTGACTTTGATCCCTTTGGTGATTTCTTCAATGACCTAAACAATTTCAGACCTTCTAGCAATACTCCTCCTATTCCCCCA
ACCCAATCAGGTGGAGGTTATGGTGGAAACGGCGGTTATGGTTCTCAAAATCATGGATCCGCTCAAACTCCGCCACCTAG
CCAAGAAAAAGGGCTGCTGGAAGAATTTGGTATCAACGTAACTGAGATTGCCCGTCGTGGAGGCATTGATCCCGTTATTG
GGCGCGACGATGAGATTATCCGTGTCATCGAGATCCTCAATCGTAGAACCAAGAATAATCCTGTTCTTATCGGTGAACCT
GGTGTCGGAAAAACGGCCGTTGTCGAAGGTCTAGCTCAGAAAATTGTCGATGGCGATGTGCCACATAAACTCCAAGGTAA
ACAAGTCATCCGTCTGGATGTGGTTAGCTTAGTTCAAGGAACGGGGATTCGAGGACAATTTGAAGAACGCATGCAAAAAC
TCATGGAAGAAATTCGCAAACGTGAGGATATCATTCTCTTTATCGATGAAATCCATGAAATTGTCGGTGCTGGTTCTGCG
AGTGATGGTAATATGGACGCAGGAAATATCCTCAAGCCAGCCCTTGCTCGTGGAGAACTGCAACTGGTCGGTGCTACTAC
CCTCAATGAATACCGTATCATTGAAAAGGATGCTGCCCTAGAGCGTCGTATGCAGCCTGTTAAAGTCGATGAACCAACGG
TGGAAGAAACAATCATTATCCTCAAAGGAATTCAAAAGAAATACGAAGACTATCACCACGTTCAATATACCGATGCTGCA
ATTGAAGCAGCTGCAACTCTTTCCAATCGCTATATCCAAGATCGCTTCTTACCTGACAAGGCCATTGACCTCCTAGATGA
AGCTGGTTCTAAGATGAACTTGACCTTGAATTTTGTAGACCCTAAAGTAATTGATCAACGCTTGATTGAGGCTGAAAATC
TCAAATCTCAAGCTACACGAGAGGAAGATTTTGAGAAGGCCGCCTACTTCCGTGACCAGATTGCTAAATATAAGGAAATG
CAAAAGAAAAAGGTTACGGACCAGGATACTCCTATCATCAGTGAGAAAACCATTGAGCATATTATCGAACAGAAAACAAA
CATCCCTGTTGGGGATTTGAAAGAGAAAGAACAATCTCAAATCATTCATCTAGCCGAAGACCTCAAATCTCATGTTATTG
GGCAAGACGATGCTGTCGATAAGATTGCCAAGGCTATTCGCCGTAATCGTGTCGGACTTGGTACTCCTAACCGCCCCATT
GGAAGCTTCCTCTTCGTCGGACCAACTGGGGTCGGTAAGACAGAACTTTCCAAACAATTAGCTATCGAACTCTTTGGTTC
TGCTGATAGCATGATTCGCTTTGACATGAGCGAATACATGGAAAAACACAGCGTAGCTAAGTTGGTCGGCGCCCCTCCAG
GTTATGTTGGCTATGATGAGGCTGGGCAATTAACTGAAAAAGTTCGCCGCAATCCATATTCTCTTATTCTCTTGGATGAA
GTAGAGAAAGCCCATCCAGATGTTATGCACATGTTCCTCCAGGTCTTGGACGATGGTCGTTTGACAGATGGACAAGGACG
CACCGTTAGCTTCAAGGACGCCATCATCATCATGACTTCAAATGCAGGTACAGGTAAGGCAGAAGCCAGCGTTGGATTTG
GGGCTGCTAGAGAAGGACGTACCAACTCTGTTCTCGGTGAACTCGGCAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGTATTATCGAATTTAAGGCTCTCAGCAAGGATAACCTCCTTCAGATTGTCGAACTCATGCTAGCAGATGTTAACAA
GCGCCTCTCCAGCAATAACATTCATTTAGATGTAACTGACAAGGTCAAGGAAAAGTTGGTTGACCTAGGTTATGATCCAA
AAATGGGAGCACGCCCTCTTCGTCGTACTATTCAAGACTATATTGAGGACGCAATCACTGACTACTACCTTGAAAATCCA
AGCGAAAAAGATCTCAAAGCAGTTATGACCAGCAAAGGCAAGATTCAAATCAAGTATGCCAAAAAAGCTGAAGTTAAAAC
TTCTGAAAAAGAAAAATAA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(293-390)

ATPase family associated with various cellular activities (AAA) (AAA)

(155-276)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

98.138

100

0.981
  clpE Streptococcus pneumoniae D39

98.138

100

0.981
  clpE Streptococcus pneumoniae R6

98.138

100

0.981
  clpE Streptococcus pneumoniae TIGR4

98.005

100

0.98
  clpE Streptococcus mutans UA159

82.667

99.734

0.824
  clpC Lactococcus lactis subsp. cremoris KW2

74.934

100

0.755
  clpC Bacillus subtilis subsp. subtilis str. 168

52.154

86.436

0.451
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.687

83.378

0.398
  clpC Streptococcus pneumoniae TIGR4

46.751

83.91

0.392
  clpC Streptococcus pneumoniae Rx1

46.751

83.91

0.392
  clpC Streptococcus pneumoniae D39

46.751

83.91

0.392
  clpC Streptococcus mutans UA159

46.89

83.378

0.391
  clpC Streptococcus thermophilus LMD-9

46.795

82.979

0.388
  clpC Streptococcus thermophilus LMG 18311

46.4

83.112

0.386

Multiple sequence alignment