Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   ACLV65_RS06860 Genome accession   NZ_OZ217342
Coordinates   1344793..1347051 (+) Length   752 a.a.
NCBI ID   WP_411864873.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis B22     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1339793..1352051
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV65_RS06830 (SMIB22_13390) - 1339869..1340741 (-) 873 WP_411864870.1 NAD(P)H-hydrate dehydratase -
  ACLV65_RS06835 (SMIB22_13400) - 1340755..1341576 (-) 822 WP_411864871.1 phosphate ABC transporter ATPase -
  ACLV65_RS06840 (SMIB22_13410) - 1341713..1342570 (-) 858 WP_411864872.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  ACLV65_RS06845 (SMIB22_13420) - 1342724..1343458 (-) 735 WP_000140954.1 amino acid ABC transporter ATP-binding protein -
  ACLV65_RS06850 (SMIB22_13430) - 1343458..1344141 (-) 684 WP_001011642.1 amino acid ABC transporter permease -
  ACLV65_RS06855 (SMIB22_13440) - 1344332..1344562 (+) 231 WP_000443570.1 DUF1797 family protein -
  ACLV65_RS06860 (SMIB22_13450) clpE 1344793..1347051 (+) 2259 WP_411864873.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  ACLV65_RS06865 (SMIB22_13460) - 1347182..1347634 (+) 453 WP_411864874.1 NUDIX hydrolase -
  ACLV65_RS06870 (SMIB22_13470) - 1347846..1348145 (+) 300 WP_000767194.1 DUF1827 family protein -
  ACLV65_RS06875 (SMIB22_13480) ezrA 1348331..1350058 (-) 1728 WP_411864875.1 septation ring formation regulator EzrA -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83680.31 Da        Isoelectric Point: 5.5397

>NTDB_id=1170132 ACLV65_RS06860 WP_411864873.1 1344793..1347051(+) (clpE) [Streptococcus mitis isolate S. mitis B22]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGMTDLNNHDFDPFGDFFNDLNNFRPSSNIPPIPP
TQSGGGYGGNGGYGSQNRGSAQTPPPSQEKGLLEEFGINVTEIARRGGIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
SDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETIIILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKVTDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKGNLLQIVELMLADVNKRLSSNNIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAITDYYLENP
SEKDLKAVMISKGKIQIKSAKKAEVKTSEKEV

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=1170132 ACLV65_RS06860 WP_411864873.1 1344793..1347051(+) (clpE) [Streptococcus mitis isolate S. mitis B22]
ATGCTTTGTCAAAACTGTAAAATCAACGACTCAACAATTCATCTTTACACCAATCTCAATGGAAAACAAAAACAAATTGA
CCTCTGTCAAAACTGCTATAAGATTATCAAGACAGATCCTAACAATAGCCTCTTTAAAGGTATGACGGATCTGAATAATC
ATGACTTTGATCCCTTTGGTGATTTCTTCAATGACCTAAACAATTTCAGACCTTCTAGCAATATTCCTCCTATTCCCCCA
ACCCAATCAGGTGGAGGTTACGGTGGAAACGGCGGTTATGGTTCCCAAAATCGTGGTTCTGCTCAAACTCCACCACCAAG
CCAAGAAAAAGGCCTGCTAGAAGAATTTGGTATCAACGTAACTGAGATTGCCCGTCGTGGAGGCATTGACCCCGTTATTG
GGCGCGACGATGAGATTATCCGTGTCATCGAGATTCTCAATCGTAGAACCAAGAATAATCCTGTTCTTATCGGTGAACCT
GGTGTCGGAAAAACGGCCGTTGTCGAAGGTCTAGCCCAGAAAATCGTTGATGGCGATGTTCCACATAAACTCCAAGGTAA
ACAAGTCATCCGTCTGGATGTGGTTAGCCTGGTCCAAGGAACGGGTATCCGAGGACAATTTGAAGAACGCATGCAAAAAC
TCATGGAAGAAATTCGCAAACGTGAGGACATCATCCTCTTTATCGACGAAATCCATGAAATTGTCGGTGCTGGTTCTGCG
AGTGATGGTAATATGGACGCAGGAAATATCCTCAAGCCAGCCCTTGCTCGGGGGGAACTGCAACTGGTCGGCGCTACTAC
CCTCAATGAATACCGTATCATTGAAAAGGATGCTGCCCTAGAGCGTCGTATGCAGCCTGTCAAAGTCGATGAACCAACCG
TGGAAGAAACAATCATTATCCTCAAAGGAATTCAAAAGAAATACGAAGACTACCACCATGTTCAGTATACTGATGCTGCA
ATTGAAGCAGCTGCAACTCTTTCCAATCGCTATATCCAAGATCGCTTCTTACCTGACAAGGCCATTGACCTCCTAGATGA
AGCTGGTTCTAAGATGAACTTGACCTTGAATTTTGTCGATCCTAAAGTAATTGATCAGCGCTTGATTGAAGCTGAAAATC
TCAAATCTCAAGCTACACGAGAAGAAGATTTTGAAAAGGCTGCCTACTTCCGTGACCAGATTGCCAAGTATAAGGAAATG
CAAAAGAAAAAGGTCACAGACCAAGATACACCTATCATAAGCGAGAAAACCATTGAGCACATTATCGAGCAGAAAACCAA
CATCCCTGTTGGTGATTTGAAAGAGAAAGAACAATCTCAACTCATCCATCTAGCCGAAGATCTCAAGTCTCATGTTATTG
GACAGGATGATGCAGTCGATAAGATTGCCAAGGCTATTCGCCGTAATCGTGTCGGACTTGGTACCCCTAACCGTCCAATT
GGAAGCTTCCTCTTTGTCGGACCAACTGGTGTCGGCAAGACAGAACTTTCCAAACAACTAGCTATCGAACTCTTTGGTTC
TGCTGATAGCATGATACGCTTTGACATGAGCGAATACATGGAAAAACACAGCGTGGCGAAGTTGGTCGGTGCCCCTCCAG
GTTATGTCGGCTACGATGAGGCTGGGCAACTGACTGAAAAAGTCCGTCGCAATCCATATTCTCTCATCCTTCTCGATGAA
GTGGAAAAAGCTCATCCAGATGTTATGCACATGTTCCTTCAAGTCTTGGACGATGGTCGTTTAACAGATGGTCAAGGACG
CACCGTTAGCTTCAAGGATGCCATCATCATTATGACTTCAAATGCTGGGACTGGAAAAGCCGAAGCCAGCGTTGGATTTG
GTGCTGCTAGAGAAGGGCGTACCAATTCTGTTCTCGGTGAACTCGGCAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGTATTATCGAATTTAAGGCTCTCAGCAAGGGTAACCTCCTTCAGATTGTCGAGCTCATGCTGGCAGATGTTAACAA
GCGCCTCTCTAGCAACAACATCCATTTAGATGTAACGGACAAGGTCAAGGAAAAATTAGTCGACCTCGGTTATGATCCAA
AAATGGGGGCGCGCCCACTTCGTCGTACTATTCAAGACTATATTGAAGACGCAATCACTGACTACTACCTTGAAAATCCA
AGCGAAAAAGACCTCAAGGCAGTTATGATCAGCAAGGGCAAGATTCAAATTAAGTCTGCCAAAAAAGCTGAAGTTAAAAC
GTCTGAAAAAGAAGTATAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)

ATPase family associated with various cellular activities (AAA) (AAA)

(155-276)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)

AAA lid domain (AAA_lid_9)

(293-390)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

98.136

99.867

0.98
  clpE Streptococcus pneumoniae D39

98.136

99.867

0.98
  clpE Streptococcus pneumoniae R6

98.136

99.867

0.98
  clpE Streptococcus pneumoniae TIGR4

98.003

99.867

0.979
  clpE Streptococcus mutans UA159

82.667

99.734

0.824
  clpC Lactococcus lactis subsp. cremoris KW2

75.297

100

0.758
  clpC Bacillus subtilis subsp. subtilis str. 168

50.96

90.027

0.459
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.847

83.378

0.399
  clpC Streptococcus pneumoniae TIGR4

46.593

83.91

0.391
  clpC Streptococcus pneumoniae Rx1

46.593

83.91

0.391
  clpC Streptococcus pneumoniae D39

46.593

83.91

0.391
  clpC Streptococcus mutans UA159

46.89

83.378

0.391
  clpC Streptococcus thermophilus LMD-9

46.795

82.979

0.388
  clpC Streptococcus thermophilus LMG 18311

46.4

83.112

0.386

Multiple sequence alignment