Detailed information NTG1169650

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACNUD0_RS00565
• Genome accession: NZ_OZ197102
• Coordinates: 73186..74229 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 23S01975-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 68186..79229

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACNUD0_RS00535	-	68607..69863 (-)	1257	WP_074347694.1	aminopeptidase	-
ACNUD0_RS00540	-	69866..70066 (-)	201	WP_000180460.1	DUF1128 family protein	-
ACNUD0_RS00545	-	70213..70677 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACNUD0_RS00550	-	70684..70959 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACNUD0_RS00555	-	71237..72454 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACNUD0_RS00560	vraR	72567..73196 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACNUD0_RS00565	vraS	73186..74229 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACNUD0_RS00570	liaF	74226..74927 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACNUD0_RS00575	-	74942..75328 (-)	387	WP_001110182.1	hypothetical protein	-
ACNUD0_RS00580	map	75545..76303 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACNUD0_RS00585	-	76887..77873 (+)	987	WP_000999712.1	FUSC family protein	-
ACNUD0_RS00590	-	78062..78475 (-)	414	WP_025174370.1	hypothetical protein	-
ACNUD0_RS00595	-	78504..78614 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1169650 ACNUD0_RS00565 WP_001017131.1 73186..74229(-) (vraS) [Staphylococcus aureus isolate 23S01975-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1169650 ACNUD0_RS00565 WP_001017131.1 73186..74229(-) (vraS) [Staphylococcus aureus isolate 23S01975-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1