Detailed information NTG1169606

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACNUD5_RS00270
• Genome accession: NZ_OZ197101
• Coordinates: 51695..52738 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 23S01948-3
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 46695..57738

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACNUD5_RS00240	-	47310..47420 (+)	111	WP_014937049.1	hypothetical protein	-
ACNUD5_RS00245	-	47449..47862 (+)	414	WP_025174370.1	hypothetical protein	-
ACNUD5_RS00250	-	48051..49037 (-)	987	WP_000999712.1	FUSC family protein	-
ACNUD5_RS00255	map	49621..50379 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACNUD5_RS00260	-	50596..50982 (+)	387	WP_001110182.1	hypothetical protein	-
ACNUD5_RS00265	liaF	50997..51698 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACNUD5_RS00270	vraS	51695..52738 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACNUD5_RS00275	vraR	52728..53357 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACNUD5_RS00280	-	53470..54687 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACNUD5_RS00285	-	54965..55240 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACNUD5_RS00290	-	55247..55711 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACNUD5_RS00295	-	55858..56058 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACNUD5_RS00300	-	56061..57317 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1169606 ACNUD5_RS00270 WP_001017131.1 51695..52738(+) (vraS) [Staphylococcus aureus isolate 23S01948-3]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1169606 ACNUD5_RS00270 WP_001017131.1 51695..52738(+) (vraS) [Staphylococcus aureus isolate 23S01948-3]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1