Detailed information NTG1169553

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACNUDU_RS06765
• Genome accession: NZ_OZ197099
• Coordinates: 1364572..1365615 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 23S00079-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1359572..1370615

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACNUDU_RS06735	-	1360187..1360297 (+)	111	WP_014937049.1	hypothetical protein	-
ACNUDU_RS06740	-	1360326..1360739 (+)	414	WP_025174370.1	hypothetical protein	-
ACNUDU_RS06745	-	1360928..1361914 (-)	987	WP_000999712.1	FUSC family protein	-
ACNUDU_RS06750	map	1362498..1363256 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACNUDU_RS06755	-	1363473..1363859 (+)	387	WP_001110182.1	hypothetical protein	-
ACNUDU_RS06760	liaF	1363874..1364575 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACNUDU_RS06765	vraS	1364572..1365615 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACNUDU_RS06770	vraR	1365605..1366234 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACNUDU_RS06775	-	1366347..1367564 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACNUDU_RS06780	-	1367842..1368117 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACNUDU_RS06785	-	1368124..1368588 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACNUDU_RS06790	-	1368735..1368935 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACNUDU_RS06795	-	1368938..1370194 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1169553 ACNUDU_RS06765 WP_001017131.1 1364572..1365615(+) (vraS) [Staphylococcus aureus isolate 23S00079-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1169553 ACNUDU_RS06765 WP_001017131.1 1364572..1365615(+) (vraS) [Staphylococcus aureus isolate 23S00079-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1