Detailed information NTG1169543

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: ACNUDU_RS02460
• Genome accession: NZ_OZ197099
• Coordinates: 491022..492371 (+)
• Length: 449 a.a.
• NCBI ID: WP_416763906.1
• Uniprot ID: -
• Organism: Staphylococcus aureus isolate 23S00079-1
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	485415..500786	491022..492371	within	0

Gene organization within MGE regions

Location: 485415..500786

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACNUDU_RS02440	-	485415..486905 (-)	1491	WP_000554504.1	RNA-binding domain-containing protein	-
ACNUDU_RS02445	-	487523..488572 (-)	1050	WP_000613248.1	hypothetical protein	-
ACNUDU_RS02450	ssb	488711..489001 (+)	291	WP_001036437.1	cassette chromosome ssDNA-binding protein	-
ACNUDU_RS02455	cch1	489001..490788 (+)	1788	WP_000122621.1	cassette chromosome replicative helicase	-
ACNUDU_RS02460	ccrA	491022..492371 (+)	1350	WP_416763906.1	cassette chromosome recombinase CcrA	Machinery gene
ACNUDU_RS02465	ccrB	492393..494021 (+)	1629	WP_001186604.1	cassette chromosome recombinase CcrB	Machinery gene
ACNUDU_RS02470	-	494543..494893 (+)	351	WP_000849672.1	SAUGI family uracil-DNA glycosylase inhibitor	-
ACNUDU_RS02475	-	494980..495291 (+)	312	WP_000700851.1	DUF960 family protein	-
ACNUDU_RS02480	-	495306..495812 (+)	507	WP_001092189.1	DUF1643 domain-containing protein	-
ACNUDU_RS02485	-	495861..497471 (+)	1611	Protein_491	IS1182 family transposase	-
ACNUDU_RS02490	-	497462..497704 (-)	243	Protein_492	type I restriction enzyme endonuclease domain-containing protein	-
ACNUDU_RS02495	-	497694..498680 (-)	987	WP_001549960.1	beta-lactam sensor/signal transducer MecR1	-
ACNUDU_RS02500	mecA	498777..500786 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52649.37 Da
• Isoelectric Point: 10.0472

>NTDB_id=1169543 ACNUDU_RS02460 WP_416763906.1 491022..492371(+) (ccrA) [Staphylococcus aureus isolate 23S00079-1]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYRVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYDYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTSSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHILTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQRTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIINQAMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=1169543 ACNUDU_RS02460 WP_416763906.1 491022..492371(+) (ccrA) [Staphylococcus aureus isolate 23S00079-1]
ATGAAACAAGTTATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACACAATTAATTCAACAAGGACAATGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
TTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATATCGTGTTCATATCTTAAGTGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGATTATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGTCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACATCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACATATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATAAATGGGCATCAAATACAACGCACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCATCAATCAAGCCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-248)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-321)

• Resolvase, N terminal domain (Resolvase) (4-147)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	97.105	100	0.971
ccrA	Staphylococcus aureus COL	74.61	100	0.746