Detailed information NTG1169379

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACNUEA_RS14465
• Genome accession: NZ_OZ197093
• Coordinates: 2882197..2883240 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 23S01465-3
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2877197..2888240

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACNUEA_RS14435	-	2877812..2877922 (+)	111	WP_014937049.1	hypothetical protein	-
ACNUEA_RS14440	-	2877951..2878364 (+)	414	WP_025174370.1	hypothetical protein	-
ACNUEA_RS14445	-	2878553..2879539 (-)	987	WP_000999712.1	FUSC family protein	-
ACNUEA_RS14450	map	2880123..2880881 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACNUEA_RS14455	-	2881098..2881484 (+)	387	WP_001110182.1	hypothetical protein	-
ACNUEA_RS14460	liaF	2881499..2882200 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACNUEA_RS14465	vraS	2882197..2883240 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACNUEA_RS14470	vraR	2883230..2883859 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACNUEA_RS14475	-	2883972..2885189 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACNUEA_RS14480	-	2885467..2885742 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACNUEA_RS14485	-	2885749..2886213 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACNUEA_RS14490	-	2886360..2886560 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACNUEA_RS14495	-	2886563..2887819 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1169379 ACNUEA_RS14465 WP_001017131.1 2882197..2883240(+) (vraS) [Staphylococcus aureus isolate 23S01465-3]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1169379 ACNUEA_RS14465 WP_001017131.1 2882197..2883240(+) (vraS) [Staphylococcus aureus isolate 23S01465-3]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1