Detailed information NTG1169169

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACNUEB_RS00400
• Genome accession: NZ_OZ197089
• Coordinates: 79006..80049 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 23S00080-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 74006..85049

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACNUEB_RS00370	-	74621..74731 (+)	111	WP_014937049.1	hypothetical protein	-
ACNUEB_RS00375	-	74760..75173 (+)	414	WP_025174370.1	hypothetical protein	-
ACNUEB_RS00380	-	75362..76348 (-)	987	WP_000999712.1	FUSC family protein	-
ACNUEB_RS00385	map	76932..77690 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACNUEB_RS00390	-	77907..78293 (+)	387	WP_001110182.1	hypothetical protein	-
ACNUEB_RS00395	liaF	78308..79009 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACNUEB_RS00400	vraS	79006..80049 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACNUEB_RS00405	vraR	80039..80668 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACNUEB_RS00410	-	80781..81998 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACNUEB_RS00415	-	82276..82551 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACNUEB_RS00420	-	82558..83022 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACNUEB_RS00425	-	83169..83369 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACNUEB_RS00430	-	83372..84628 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1169169 ACNUEB_RS00400 WP_001017131.1 79006..80049(+) (vraS) [Staphylococcus aureus isolate 23S00080-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1169169 ACNUEB_RS00400 WP_001017131.1 79006..80049(+) (vraS) [Staphylococcus aureus isolate 23S00080-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1