Detailed information NTG1169166

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACNUD7_RS13610
• Genome accession: NZ_OZ197088
• Coordinates: 2743604..2744647 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 23S01947-3
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2738604..2749647

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACNUD7_RS13580	-	2739219..2739329 (+)	111	WP_014937049.1	hypothetical protein	-
ACNUD7_RS13585	-	2739358..2739771 (+)	414	WP_025174370.1	hypothetical protein	-
ACNUD7_RS13590	-	2739960..2740946 (-)	987	WP_000999712.1	FUSC family protein	-
ACNUD7_RS13595	map	2741530..2742288 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACNUD7_RS13600	-	2742505..2742891 (+)	387	WP_001110182.1	hypothetical protein	-
ACNUD7_RS13605	liaF	2742906..2743607 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACNUD7_RS13610	vraS	2743604..2744647 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACNUD7_RS13615	vraR	2744637..2745266 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACNUD7_RS13620	-	2745379..2746596 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACNUD7_RS13625	-	2746874..2747149 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACNUD7_RS13630	-	2747156..2747620 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACNUD7_RS13635	-	2747767..2747967 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACNUD7_RS13640	-	2747970..2749226 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1169166 ACNUD7_RS13610 WP_001017131.1 2743604..2744647(+) (vraS) [Staphylococcus aureus isolate 23S01947-3]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1169166 ACNUD7_RS13610 WP_001017131.1 2743604..2744647(+) (vraS) [Staphylococcus aureus isolate 23S01947-3]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1