Detailed information NTG1169088

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACNUEF_RS00585
• Genome accession: NZ_OZ197087
• Coordinates: 74986..76029 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 23S00037-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 69986..81029

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACNUEF_RS00555	-	70407..71663 (-)	1257	WP_074347694.1	aminopeptidase	-
ACNUEF_RS00560	-	71666..71866 (-)	201	WP_000180460.1	DUF1128 family protein	-
ACNUEF_RS00565	-	72013..72477 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACNUEF_RS00570	-	72484..72759 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACNUEF_RS00575	-	73037..74254 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACNUEF_RS00580	vraR	74367..74996 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACNUEF_RS00585	vraS	74986..76029 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACNUEF_RS00590	liaF	76026..76727 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACNUEF_RS00595	-	76742..77128 (-)	387	WP_001110182.1	hypothetical protein	-
ACNUEF_RS00600	map	77345..78103 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACNUEF_RS00605	-	78687..79673 (+)	987	WP_000999712.1	FUSC family protein	-
ACNUEF_RS00610	-	79862..80275 (-)	414	WP_025174370.1	hypothetical protein	-
ACNUEF_RS00615	-	80304..80414 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1169088 ACNUEF_RS00585 WP_001017131.1 74986..76029(-) (vraS) [Staphylococcus aureus isolate 23S00037-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1169088 ACNUEF_RS00585 WP_001017131.1 74986..76029(-) (vraS) [Staphylococcus aureus isolate 23S00037-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1