Detailed information NTG1168931

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACNUEC_RS08890
• Genome accession: NZ_OZ197083
• Coordinates: 1770413..1771456 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 23S01949-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1765413..1776456

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACNUEC_RS08860	-	1766028..1766138 (+)	111	WP_014937049.1	hypothetical protein	-
ACNUEC_RS08865	-	1766167..1766580 (+)	414	WP_025174370.1	hypothetical protein	-
ACNUEC_RS08870	-	1766769..1767755 (-)	987	WP_000999712.1	FUSC family protein	-
ACNUEC_RS08875	map	1768339..1769097 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACNUEC_RS08880	-	1769314..1769700 (+)	387	WP_001110182.1	hypothetical protein	-
ACNUEC_RS08885	liaF	1769715..1770416 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACNUEC_RS08890	vraS	1770413..1771456 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACNUEC_RS08895	vraR	1771446..1772075 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACNUEC_RS08900	-	1772188..1773405 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACNUEC_RS08905	-	1773683..1773958 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACNUEC_RS08910	-	1773965..1774429 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACNUEC_RS08915	-	1774576..1774776 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACNUEC_RS08920	-	1774779..1776035 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1168931 ACNUEC_RS08890 WP_001017131.1 1770413..1771456(+) (vraS) [Staphylococcus aureus isolate 23S01949-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1168931 ACNUEC_RS08890 WP_001017131.1 1770413..1771456(+) (vraS) [Staphylococcus aureus isolate 23S01949-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1