Detailed information NTG1165398

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACE4RH_RS10490
• Genome accession: NZ_OZ059824
• Coordinates: 2053354..2054397 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate E3_22S00626-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2048354..2059397

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACE4RH_RS10460	-	2048775..2050031 (-)	1257	WP_074347694.1	aminopeptidase	-
ACE4RH_RS10465	-	2050034..2050234 (-)	201	WP_000180460.1	DUF1128 family protein	-
ACE4RH_RS10470	-	2050381..2050845 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACE4RH_RS10475	-	2050852..2051127 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACE4RH_RS10480	-	2051405..2052622 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACE4RH_RS10485	vraR	2052735..2053364 (-)	630	WP_374750092.1	two-component system response regulator VraR	Regulator
ACE4RH_RS10490	vraS	2053354..2054397 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACE4RH_RS10495	liaF	2054394..2055095 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACE4RH_RS10500	-	2055110..2055496 (-)	387	WP_001110182.1	hypothetical protein	-
ACE4RH_RS10505	map	2055713..2056471 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACE4RH_RS10510	-	2057055..2058041 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
ACE4RH_RS10515	-	2058230..2058643 (-)	414	WP_025174370.1	hypothetical protein	-
ACE4RH_RS10520	-	2058672..2058782 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1165398 ACE4RH_RS10490 WP_001017131.1 2053354..2054397(-) (vraS) [Staphylococcus aureus isolate E3_22S00626-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1165398 ACE4RH_RS10490 WP_001017131.1 2053354..2054397(-) (vraS) [Staphylococcus aureus isolate E3_22S00626-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1