Detailed information NTG1165366

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACE4RD_RS14420
• Genome accession: NZ_OZ059823
• Coordinates: 2853095..2854138 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate E2_22S00623-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2848095..2859138

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACE4RD_RS14390	-	2848516..2849772 (-)	1257	WP_074347694.1	aminopeptidase	-
ACE4RD_RS14395	-	2849775..2849975 (-)	201	WP_000180460.1	DUF1128 family protein	-
ACE4RD_RS14400	-	2850122..2850586 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACE4RD_RS14405	-	2850593..2850868 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACE4RD_RS14410	-	2851146..2852363 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACE4RD_RS14415	vraR	2852476..2853105 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACE4RD_RS14420	vraS	2853095..2854138 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACE4RD_RS14425	liaF	2854135..2854836 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACE4RD_RS14430	-	2854851..2855237 (-)	387	WP_001110182.1	hypothetical protein	-
ACE4RD_RS14435	map	2855454..2856212 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACE4RD_RS14440	-	2856796..2857782 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
ACE4RD_RS14445	-	2857971..2858384 (-)	414	WP_025174370.1	hypothetical protein	-
ACE4RD_RS14450	-	2858413..2858523 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1165366 ACE4RD_RS14420 WP_001017131.1 2853095..2854138(-) (vraS) [Staphylococcus aureus isolate E2_22S00623-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1165366 ACE4RD_RS14420 WP_001017131.1 2853095..2854138(-) (vraS) [Staphylococcus aureus isolate E2_22S00623-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1