Detailed information NTG1165295

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACE4RE_RS07745
• Genome accession: NZ_OZ059822
• Coordinates: 1578193..1579236 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate E9_23S01315-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1573193..1584236

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACE4RE_RS07715	-	1573808..1573918 (+)	111	WP_014937049.1	hypothetical protein	-
ACE4RE_RS07720	-	1573947..1574360 (+)	414	WP_025174370.1	hypothetical protein	-
ACE4RE_RS07725	-	1574549..1575535 (-)	987	WP_000999712.1	aromatic acid exporter family protein	-
ACE4RE_RS07730	map	1576119..1576877 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACE4RE_RS07735	-	1577094..1577480 (+)	387	WP_001110182.1	hypothetical protein	-
ACE4RE_RS07740	liaF	1577495..1578196 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACE4RE_RS07745	vraS	1578193..1579236 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACE4RE_RS07750	vraR	1579226..1579855 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACE4RE_RS07755	-	1579968..1581185 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACE4RE_RS07760	-	1581463..1581738 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACE4RE_RS07765	-	1581745..1582209 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACE4RE_RS07770	-	1582356..1582556 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACE4RE_RS07775	-	1582559..1583815 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1165295 ACE4RE_RS07745 WP_001017131.1 1578193..1579236(+) (vraS) [Staphylococcus aureus isolate E9_23S01315-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1165295 ACE4RE_RS07745 WP_001017131.1 1578193..1579236(+) (vraS) [Staphylococcus aureus isolate E9_23S01315-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1