Detailed information NTG1165157

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACE4RG_RS06650
• Genome accession: NZ_OZ059819
• Coordinates: 1356092..1357135 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate H2_22S00635-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1351092..1362135

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACE4RG_RS06620	-	1351707..1351817 (+)	111	WP_014937049.1	hypothetical protein	-
ACE4RG_RS06625	-	1351846..1352259 (+)	414	WP_025174370.1	hypothetical protein	-
ACE4RG_RS06630	-	1352448..1353434 (-)	987	WP_000999712.1	aromatic acid exporter family protein	-
ACE4RG_RS06635	map	1354018..1354776 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACE4RG_RS06640	-	1354993..1355379 (+)	387	WP_001110182.1	hypothetical protein	-
ACE4RG_RS06645	liaF	1355394..1356095 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACE4RG_RS06650	vraS	1356092..1357135 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACE4RG_RS06655	vraR	1357125..1357754 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACE4RG_RS06660	-	1357867..1359084 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACE4RG_RS06665	-	1359362..1359637 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACE4RG_RS06670	-	1359644..1360108 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACE4RG_RS06675	-	1360255..1360455 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACE4RG_RS06680	-	1360458..1361714 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1165157 ACE4RG_RS06650 WP_001017131.1 1356092..1357135(+) (vraS) [Staphylococcus aureus isolate H2_22S00635-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1165157 ACE4RG_RS06650 WP_001017131.1 1356092..1357135(+) (vraS) [Staphylococcus aureus isolate H2_22S00635-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1