Detailed information NTG1165104

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACE4RB_RS00240
• Genome accession: NZ_OZ059818
• Coordinates: 46917..47960 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate E4_22S00627-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 41917..52960

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACE4RB_RS00210	-	42532..42642 (+)	111	WP_014937049.1	hypothetical protein	-
ACE4RB_RS00215	-	42671..43084 (+)	414	WP_025174370.1	hypothetical protein	-
ACE4RB_RS00220	-	43273..44259 (-)	987	WP_000999712.1	aromatic acid exporter family protein	-
ACE4RB_RS00225	map	44843..45601 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACE4RB_RS00230	-	45818..46204 (+)	387	WP_001110182.1	hypothetical protein	-
ACE4RB_RS00235	liaF	46219..46920 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACE4RB_RS00240	vraS	46917..47960 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACE4RB_RS00245	vraR	47950..48579 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACE4RB_RS00250	-	48692..49909 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACE4RB_RS00255	-	50187..50462 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACE4RB_RS00260	-	50469..50933 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACE4RB_RS00265	-	51080..51280 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACE4RB_RS00270	-	51283..52539 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1165104 ACE4RB_RS00240 WP_001017131.1 46917..47960(+) (vraS) [Staphylococcus aureus isolate E4_22S00627-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1165104 ACE4RB_RS00240 WP_001017131.1 46917..47960(+) (vraS) [Staphylococcus aureus isolate E4_22S00627-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1