Detailed information NTG1165098

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: ACE4RF_RS12215
• Genome accession: NZ_OZ059817
• Coordinates: 2432402..2433751 (+)
• Length: 449 a.a.
• NCBI ID: WP_000815652.1
• Uniprot ID: Q8VUV4
• Organism: Staphylococcus aureus isolate E6_22S00629-1
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	2426795..2442166	2432402..2433751	within	0

Gene organization within MGE regions

Location: 2426795..2442166

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACE4RF_RS12195	-	2426795..2428285 (-)	1491	WP_000554504.1	RNA-binding domain-containing protein	-
ACE4RF_RS12200	-	2428903..2429952 (-)	1050	WP_000613248.1	hypothetical protein	-
ACE4RF_RS12205	ssb	2430091..2430381 (+)	291	WP_001036437.1	cassette chromosome ssDNA-binding protein	-
ACE4RF_RS12210	cch1	2430381..2432168 (+)	1788	WP_000122621.1	cassette chromosome replicative helicase	-
ACE4RF_RS12215	ccrA	2432402..2433751 (+)	1350	WP_000815652.1	cassette chromosome recombinase CcrA	Machinery gene
ACE4RF_RS12220	ccrB	2433773..2435401 (+)	1629	WP_001186604.1	cassette chromosome recombinase CcrB	Machinery gene
ACE4RF_RS12225	-	2435923..2436273 (+)	351	WP_000849672.1	SAUGI family uracil-DNA glycosylase inhibitor	-
ACE4RF_RS12230	-	2436360..2436671 (+)	312	WP_000700851.1	DUF960 family protein	-
ACE4RF_RS12235	-	2436686..2437192 (+)	507	WP_001092189.1	DUF1643 domain-containing protein	-
ACE4RF_RS12240	-	2437241..2438851 (+)	1611	Protein_2367	IS1182 family transposase	-
ACE4RF_RS12245	-	2438842..2439087 (-)	246	Protein_2368	type I restriction enzyme endonuclease domain-containing protein	-
ACE4RF_RS12250	-	2439074..2440060 (-)	987	WP_001549960.1	beta-lactam sensor/signal transducer MecR1	-
ACE4RF_RS12255	mecA	2440157..2442166 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52616.30 Da
• Isoelectric Point: 10.0062

>NTDB_id=1165098 ACE4RF_RS12215 WP_000815652.1 2432402..2433751(+) (ccrA) [Staphylococcus aureus isolate E6_22S00629-1]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYRVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYDYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTSSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHILTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQAMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=1165098 ACE4RF_RS12215 WP_000815652.1 2432402..2433751(+) (ccrA) [Staphylococcus aureus isolate E6_22S00629-1]
ATGAAACAAGTTATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACACAATTAATTCAACAAGGACAATGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
TTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATATCGTGTTCATATCTTAAGTGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGATTATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGTCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACATCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACATATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATAAATGGGCATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAGCCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-248)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-321)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q8VUV4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	97.55	100	0.976
ccrA	Staphylococcus aureus COL	74.833	100	0.748