Detailed information NTG1161743

Bioinformatically predicted

Overview

• Name: endA
• Type: Machinery gene
• Locus tag: U8955_RS08705
• Genome accession: NZ_OY769914
• Coordinates: 1734080..1734904 (-)
• Length: 274 a.a.
• NCBI ID: WP_038804570.1
• Uniprot ID: A0A7T2ZWS1
• Organism: Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746
• Function: cleavage of dsDNA into ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1729080..1739904

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U8955_RS08690 (SDENT7746_08720)	amiA	1730103..1732082 (-)	1980	WP_038804568.1	peptide ABC transporter substrate-binding protein	Regulator
U8955_RS08700 (SDENT7746_08730)	-	1732608..1733939 (-)	1332	WP_038804569.1	hemolysin family protein	-
U8955_RS08705 (SDENT7746_08735)	endA	1734080..1734904 (-)	825	WP_038804570.1	DNA/RNA non-specific endonuclease	Machinery gene
U8955_RS08710 (SDENT7746_08740)	-	1734945..1735136 (-)	192	WP_000791880.1	DNA-directed RNA polymerase subunit beta	-
U8955_RS08715 (SDENT7746_08745)	murA	1735126..1736406 (-)	1281	WP_038804571.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
U8955_RS08720	-	1736429..1736659 (-)	231	WP_080563327.1	DUF1146 family protein	-
U8955_RS08725 (SDENT7746_08750)	sepM	1736715..1737752 (-)	1038	WP_038804572.1	SepM family pheromone-processing serine protease	Regulator
U8955_RS08730 (SDENT7746_08755)	coaD	1737736..1738224 (-)	489	WP_038804573.1	pantetheine-phosphate adenylyltransferase	-
U8955_RS08735 (SDENT7746_08760)	rsmD	1738214..1738753 (-)	540	WP_038804574.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
U8955_RS08740 (SDENT7746_08765)	asnA	1738818..1739810 (-)	993	WP_038804575.1	aspartate--ammonia ligase	-

Sequence

Protein

• Length: 274 a.a.
• Molecular weight: 30045.73 Da
• Isoelectric Point: 9.9038

>NTDB_id=1161743 U8955_RS08705 WP_038804570.1 1734080..1734904(-) (endA) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
MNKKTRQALIGLLIFLLLSAGSYYIKQMQLTSNTPKTKVSQKKQASEAPSQELAESVLTESIKNQIKGDLEWNGAGAFIV
NGNKTNLDAKVSSKPYADNKTKPVGKETVPTVANAILSKATRQYKNREETGNGSTSWTPPGWHQVKNLKGTYTHAVDRGH
LLGYALIGGLDGFDASTSNPKNIAVQTAWANQAQAEDSTGQNYYESLVRKALDQNKRVRYRVTLHYATNEDLVPSASQIE
AKSSDGELEFNVLIPNVQKGIQLDYRTGQVTVTN

Nucleotide

• Length: 825 bp

>NTDB_id=1161743 U8955_RS08705 WP_038804570.1 1734080..1734904(-) (endA) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
ATGAACAAAAAAACGAGACAGGCTCTGATAGGGCTACTCATATTCTTACTATTATCTGCTGGTAGCTATTATATCAAGCA
GATGCAGTTGACATCAAACACGCCTAAAACCAAAGTTAGTCAGAAAAAACAAGCTTCAGAAGCTCCTAGTCAGGAGTTGG
CTGAAAGTGTCTTAACTGAGTCAATCAAAAACCAAATCAAGGGTGATCTCGAGTGGAATGGAGCAGGGGCCTTCATTGTC
AATGGCAATAAAACCAATCTAGATGCCAAGGTTTCTAGCAAACCCTATGCGGATAATAAAACAAAACCAGTCGGGAAAGA
GACAGTCCCAACTGTTGCCAATGCCATCTTATCCAAAGCCACTCGTCAGTATAAGAATCGTGAAGAGACTGGAAATGGAT
CTACCTCTTGGACGCCACCAGGGTGGCATCAGGTCAAGAATCTAAAGGGGACCTATACACATGCAGTTGACAGAGGACAC
CTGCTGGGCTATGCCTTAATAGGTGGTTTGGATGGTTTTGATGCCTCTACCAGCAATCCCAAGAACATTGCAGTCCAGAC
AGCTTGGGCGAATCAAGCGCAAGCTGAGGATTCGACAGGTCAGAACTACTATGAGAGTTTGGTCAGAAAAGCCTTGGACC
AGAATAAGAGAGTCCGTTATCGGGTGACGCTTCACTATGCGACAAATGAGGATCTAGTTCCATCCGCTTCACAAATCGAA
GCCAAGTCTTCGGATGGTGAATTGGAATTCAATGTCCTGATCCCCAATGTTCAAAAGGGAATCCAGCTTGATTACCGAAC
AGGTCAAGTCACAGTGACAAACTAG

Domains

Predicted by InterproScan.

• DNA/RNA non-specific endonuclease (Endonuclease_NS) (76-273)

3D structure

• AlphaFold DB: A0A7T2ZWS1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
endA	Streptococcus pneumoniae Rx1	89.377	99.635	0.891
endA	Streptococcus pneumoniae D39	89.377	99.635	0.891
endA	Streptococcus pneumoniae R6	89.377	99.635	0.891
endA	Streptococcus pneumoniae TIGR4	89.377	99.635	0.891