Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   U8955_RS03385 Genome accession   NZ_OY769914
Coordinates   664501..666759 (-) Length   752 a.a.
NCBI ID   WP_038804980.1    Uniprot ID   A0A7T2ZUZ8
Organism   Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 659501..671759
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U8955_RS03365 (SDENT7746_03390) - 660487..661830 (+) 1344 WP_038804977.1 DEAD/DEAH box helicase -
  U8955_RS03370 (SDENT7746_03395) metK 662299..663489 (+) 1191 WP_000003926.1 methionine adenosyltransferase -
  U8955_RS03375 (SDENT7746_03400) - 663560..663859 (-) 300 WP_000767191.1 DUF1827 family protein -
  U8955_RS03380 (SDENT7746_03405) - 663918..664370 (-) 453 WP_038804979.1 NUDIX hydrolase -
  U8955_RS03385 (SDENT7746_03410) clpE 664501..666759 (-) 2259 WP_038804980.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  U8955_RS03390 (SDENT7746_03415) - 666996..667226 (-) 231 WP_000443579.1 DUF1797 family protein -
  U8955_RS03395 (SDENT7746_03420) - 667417..668100 (+) 684 WP_038804981.1 amino acid ABC transporter permease -
  U8955_RS03400 (SDENT7746_03425) - 668100..668834 (+) 735 WP_038804982.1 amino acid ABC transporter ATP-binding protein -
  U8955_RS03405 (SDENT7746_03430) - 668868..669188 (+) 321 WP_038804984.1 TfoX/Sxy family protein -
  U8955_RS03410 (SDENT7746_03435) - 669337..670194 (+) 858 WP_038804985.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  U8955_RS03415 (SDENT7746_03440) - 670199..670972 (+) 774 WP_000673624.1 HAD hydrolase family protein -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83978.31 Da        Isoelectric Point: 5.1820

>NTDB_id=1161715 U8955_RS03385 WP_038804980.1 664501..666759(-) (clpE) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
MLCQNCKINDSTIHLYTNINGQQKQIDLCQNCYKIIKTDPNNTLFKGMTDLNNRDFDPFGDFFNDLNNFRPSSNNIPPTQ
SGDGHGGNGGYGPQNRGPLQTPPSQERGLLEEYGINITEIARRGDIDPVIGRDEEIIRVIEILNRRTKNNPVLIGEPGVG
KTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSAGDG
NMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGVQKKYEDYHHVKYTDAAIEA
AATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKAQATREEDFEKAAYFRDQIAKYKEMQKN
KVTDQDTPIISEKTIEHIIEQKTNIPVGELKEKEQSQLIHLAEDLKAHVIGQDEAVDKIAKAIRRNRVGLGTPNRPIGSF
LFVGPTGVGKTELSKQLAIELFGSANSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDEVEK
AHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRFDGI
IEFKPLSKDNLLQIVELMLADVNKRLSSNNIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDYYLENPSEK
DLKAIMTSNGKIQIKSAKKSEKAEENASEKEE

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=1161715 U8955_RS03385 WP_038804980.1 664501..666759(-) (clpE) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
ATGCTCTGTCAAAACTGTAAAATAAACGACTCAACAATTCATCTGTATACCAATATCAATGGACAGCAAAAACAAATTGA
TCTCTGTCAAAATTGCTATAAAATTATCAAAACAGACCCAAACAATACCCTCTTTAAAGGAATGACTGACCTAAACAATC
GTGACTTTGATCCTTTCGGAGACTTTTTCAATGATTTGAACAATTTCAGACCTTCTTCTAATAACATTCCTCCCACTCAA
TCAGGTGATGGTCACGGTGGAAATGGGGGTTATGGGCCTCAAAACCGCGGTCCACTTCAAACACCTCCTAGCCAAGAAAG
AGGACTCCTAGAGGAATATGGTATCAACATTACTGAGATTGCTCGTAGAGGAGATATTGACCCTGTTATCGGTCGAGATG
AGGAGATTATTCGCGTTATCGAAATCCTCAACCGTCGAACAAAAAACAATCCTGTCCTCATCGGAGAACCAGGTGTTGGT
AAAACAGCCGTTGTGGAAGGTCTAGCTCAGAAGATTGTCGATGGCGATGTTCCCCATAAACTCCAAGGCAAGCAGGTCAT
CCGTCTGGATGTGGTCAGTCTAGTTCAAGGAACAGGGATTCGAGGCCAATTTGAAGAGCGTATGCAAAAGCTCATGGAAG
AGATACGCAAACGTGAGGATATCATTCTCTTTATCGACGAAATCCATGAAATTGTCGGTGCGGGATCTGCTGGCGATGGC
AATATGGATGCAGGAAATATCCTCAAACCTGCCCTTGCCCGTGGTGAATTGCAACTGGTCGGTGCTACTACTCTCAATGA
ATACCGCATCATTGAAAAAGATGCTGCTTTGGAGCGCCGTATGCAGCCTGTCAAGGTAGATGAACCAACTGTCGAAGAAA
CCATTACCATCCTCAAAGGGGTTCAAAAGAAATACGAAGACTACCATCACGTCAAGTATACCGATGCTGCTATCGAAGCA
GCTGCTACTCTTTCCAATCGTTACATCCAAGATCGTTTCTTGCCTGACAAGGCTATTGACCTTTTAGACGAAGCCGGTTC
AAAGATGAATTTGACGCTGAACTTTGTTGATCCTAAAGTGATTGATCAACGCTTGATTGAAGCTGAAAATCTCAAGGCAC
AAGCTACACGAGAGGAAGACTTTGAAAAAGCTGCCTACTTCCGTGATCAGATTGCCAAGTACAAGGAAATGCAAAAGAAC
AAGGTGACCGATCAGGATACTCCAATCATCAGCGAGAAAACGATTGAACATATCATCGAGCAGAAAACCAATATCCCTGT
TGGGGAGCTAAAAGAAAAAGAACAGTCTCAATTGATCCATCTAGCAGAAGACCTCAAGGCCCATGTTATCGGACAAGACG
AGGCTGTCGATAAGATTGCCAAAGCCATCCGTCGTAATCGTGTTGGACTTGGTACTCCCAACCGCCCAATCGGAAGTTTC
CTCTTTGTCGGACCAACTGGTGTCGGTAAGACAGAACTTTCCAAACAACTAGCCATTGAGCTCTTTGGTTCTGCTAACAG
CATGATTCGCTTTGATATGAGTGAATACATGGAAAAACACAGCGTGGCTAAGTTAGTCGGAGCCCCTCCAGGCTATGTCG
GCTACGATGAAGCTGGTCAGTTAACGGAAAAAGTTCGTCGCAATCCTTACTCTCTCATCCTTCTCGATGAAGTTGAAAAA
GCCCACCCAGATGTGATGCACATGTTCCTCCAAGTCTTGGACGATGGTCGTTTGACTGATGGGCAAGGACGAACAGTTAG
CTTTAAGGATGCCATCATTATCATGACCTCAAATGCGGGTACTGGTAAGGCCGAAGCCAGCGTTGGTTTTGGAGCTGCTC
GTGAAGGTCGAACCAACTCTGTTCTCGGTGAACTCGGCAACTTCTTTAGTCCTGAGTTTATGAACCGTTTTGACGGCATC
ATCGAATTTAAACCTCTCAGCAAGGACAACCTTCTCCAAATCGTCGAACTCATGCTAGCAGATGTCAACAAACGCCTCTC
CAGCAACAATATCCACCTTGATGTGACAGACAAGGTCAAGGAAAAGTTGGTTGACTTGGGATATGATCCAAAAATGGGAG
CACGGCCACTCCGCCGTACCATTCAAGACCATATCGAGGATGCTATCACAGACTACTACCTTGAAAACCCAAGTGAAAAA
GACCTCAAGGCAATTATGACAAGCAATGGCAAGATTCAAATCAAATCTGCCAAGAAAAGTGAGAAAGCAGAAGAGAATGC
TTCTGAAAAAGAAGAATAA

Domains

Predicted by InterproScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(152-271)

AAA domain (Cdc48 subfamily) (AAA_2)

(475-638)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(646-720)

AAA lid domain (AAA_lid_9)

(290-387)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7T2ZUZ8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

94.305

100

0.947
  clpE Streptococcus pneumoniae D39

94.305

100

0.947
  clpE Streptococcus pneumoniae R6

94.305

100

0.947
  clpE Streptococcus pneumoniae TIGR4

94.172

100

0.945
  clpE Streptococcus mutans UA159

83.156

100

0.834
  clpC Lactococcus lactis subsp. cremoris KW2

76.291

100

0.766
  clpC Bacillus subtilis subsp. subtilis str. 168

52.308

86.436

0.452
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.546

86.702

0.412
  clpC Streptococcus thermophilus LMD-9

46.751

83.91

0.392
  clpC Streptococcus pneumoniae Rx1

47.343

82.58

0.391
  clpC Streptococcus pneumoniae D39

47.343

82.58

0.391
  clpC Streptococcus pneumoniae TIGR4

47.343

82.58

0.391
  clpC Streptococcus thermophilus LMG 18311

46.508

83.777

0.39
  clpC Streptococcus mutans UA159

46.508

83.777

0.39

Multiple sequence alignment