Detailed information NTG0115776

Bioinformatically predicted

Overview

• Name: endA
• Type: Machinery gene
• Locus tag: SMUFR_RS06970
• Genome accession: NZ_CP007016
• Coordinates: 1450196..1451077 (-)
• Length: 293 a.a.
• NCBI ID: WP_002262935.1
• Uniprot ID: Q8DT59
• Organism: Streptococcus mutans UA159-FR
• Function: cleavage of dsDNA into ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1445196..1456077

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMUFR_RS06945 (SMUFR_1316)	vicR	1446090..1446797 (-)	708	WP_002262930.1	response regulator YycF	Regulator
SMUFR_RS06950 (SMUFR_1317)	-	1447150..1447932 (+)	783	WP_002262931.1	amino acid ABC transporter ATP-binding protein	-
SMUFR_RS06955 (SMUFR_1318)	-	1447929..1448741 (+)	813	WP_002262932.1	transporter substrate-binding domain-containing protein	-
SMUFR_RS06960 (SMUFR_1319)	-	1448759..1449463 (+)	705	WP_002262933.1	amino acid ABC transporter permease	-
SMUFR_RS06965 (SMUFR_1320)	-	1449478..1450128 (+)	651	WP_002262934.1	amino acid ABC transporter permease	-
SMUFR_RS06970 (SMUFR_1321)	endA	1450196..1451077 (-)	882	WP_002262935.1	DNA/RNA non-specific endonuclease	Machinery gene
SMUFR_RS06975 (SMUFR_1322)	-	1451119..1451307 (-)	189	WP_002262936.1	DNA-directed RNA polymerase subunit beta	-
SMUFR_RS06980 (SMUFR_1323)	murA	1451310..1452581 (-)	1272	WP_002262937.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
SMUFR_RS06985 (SMUFR_1324)	-	1452647..1452880 (-)	234	WP_002285829.1	DUF1146 family protein	-
SMUFR_RS06990 (SMUFR_1325)	-	1453153..1453569 (-)	417	WP_002262939.1	F0F1 ATP synthase subunit epsilon	-
SMUFR_RS06995 (SMUFR_1326)	atpD	1453583..1454989 (-)	1407	WP_002262940.1	F0F1 ATP synthase subunit beta	-
SMUFR_RS07000 (SMUFR_1327)	-	1455015..1455893 (-)	879	WP_002262941.1	F0F1 ATP synthase subunit gamma	-

Sequence

Protein

• Length: 293 a.a.
• Molecular weight: 32130.72 Da
• Isoelectric Point: 9.5337

>NTDB_id=115776 SMUFR_RS06970 WP_002262935.1 1450196..1451077(-) (endA) [Streptococcus mutans UA159-FR]
MTRKTNKSQRKQQKLCLSLLAALSVFVCTYIATSDHIADSNPIKQAAQLLTGKNKDILSNGSMSHQATPSQELANTVMTD
AVKNALGRQIEWSGAGSFIINHNKTDLNADVASQPYASNQTKIVQGQTVPTVANALLSKATRQYRNRQETGNGRTNWQPA
GWHQLYDLPGDYDHAVDRGHLLAYALVGGLKRFDASTSNPQNVATQAAWANEANSSNSRGQNYYETLIRKALDSHKRVRY
RVTLIYDDNNDILASGSHLEAKSSDGSLEFNVFIPNVQSGLTFDYATGQVKAN

Nucleotide

• Length: 882 bp

>NTDB_id=115776 SMUFR_RS06970 WP_002262935.1 1450196..1451077(-) (endA) [Streptococcus mutans UA159-FR]
ATGACTAGAAAAACGAACAAGTCTCAGCGAAAACAGCAAAAATTATGCTTATCTCTCCTTGCTGCTTTGAGCGTATTTGT
TTGTACTTATATTGCAACCAGTGATCATATTGCTGATAGTAACCCTATAAAGCAGGCTGCCCAATTATTGACAGGTAAAA
ACAAGGATATACTTTCAAATGGTTCAATGAGCCATCAAGCGACTCCCAGTCAAGAATTAGCCAATACTGTTATGACGGAT
GCAGTAAAAAATGCCTTGGGTAGACAAATTGAATGGAGTGGTGCAGGTTCTTTCATTATTAATCATAATAAAACTGACCT
TAACGCTGATGTTGCTAGCCAACCGTATGCTAGTAATCAGACCAAAATCGTTCAAGGACAGACAGTACCAACAGTAGCAA
ATGCTTTGTTAAGTAAGGCTACTCGTCAGTACCGAAACCGCCAAGAGACAGGAAATGGCAGGACAAATTGGCAGCCAGCA
GGCTGGCATCAGCTTTATGATTTGCCGGGTGACTATGATCACGCGGTTGATCGTGGACACTTATTGGCTTATGCTTTGGT
TGGTGGTTTGAAACGATTTGATGCTTCAACGAGTAATCCTCAAAATGTAGCAACACAAGCAGCTTGGGCTAATGAAGCCA
ATAGTTCAAACTCAAGGGGACAAAATTATTATGAAACACTGATTAGAAAAGCTTTGGATAGTCATAAGCGTGTTCGTTAT
CGTGTGACTCTTATCTATGATGACAACAATGATATCTTAGCCAGTGGCAGTCATCTAGAAGCCAAATCATCAGATGGCAG
TCTAGAGTTCAATGTCTTTATTCCTAATGTTCAAAGCGGTTTGACCTTTGATTATGCAACAGGACAAGTTAAGGCAAATT
AA

Domains

Predicted by InterproScan.

• DNA/RNA non-specific endonuclease (Endonuclease_NS) (99-251)

3D structure

• AlphaFold DB: Q8DT59

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
endA	Streptococcus pneumoniae Rx1	64.103	79.863	0.512
endA	Streptococcus pneumoniae D39	64.103	79.863	0.512
endA	Streptococcus pneumoniae R6	64.103	79.863	0.512
endA	Streptococcus pneumoniae TIGR4	64.103	79.863	0.512