Detailed information NTG0115756

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: SMUFR_RS02670
• Genome accession: NZ_CP007016
• Coordinates: 525017..527278 (-)
• Length: 753 a.a.
• NCBI ID: WP_002263569.1
• Uniprot ID: Q8DVD0
• Organism: Streptococcus mutans UA159-FR
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 520017..532278

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMUFR_RS02650 (SMUFR_0483)	ileS	520517..523309 (+)	2793	WP_002262075.1	isoleucine--tRNA ligase	-
SMUFR_RS02660 (SMUFR_0484)	-	524082..524384 (-)	303	WP_002263571.1	DUF1827 family protein	-
SMUFR_RS02665 (SMUFR_0485)	-	524451..524906 (-)	456	WP_002263570.1	NUDIX hydrolase	-
SMUFR_RS02670 (SMUFR_0486)	clpE	525017..527278 (-)	2262	WP_002263569.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
SMUFR_RS02675 (SMUFR_0487)	argF	527535..528515 (+)	981	WP_002263568.1	ornithine carbamoyltransferase	-
SMUFR_RS02680 (SMUFR_0488)	-	528592..528822 (+)	231	WP_002263567.1	YkuJ family protein	-
SMUFR_RS02695 (SMUFR_0491)	-	530475..531161 (+)	687	WP_002263566.1	amino acid ABC transporter permease	-
SMUFR_RS02700 (SMUFR_0492)	-	531161..531895 (+)	735	WP_002263565.1	amino acid ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 753 a.a.
• Molecular weight: 83733.90 Da
• Isoelectric Point: 5.0597

>NTDB_id=115756 SMUFR_RS02670 WP_002263569.1 525017..527278(-) (clpE) [Streptococcus mutans UA159-FR]
MLCQNCKLNEATIHLYANVNGQQKQIDLCQNCYQIMKTDPENGPLNHLSQQNSSSINPFFDDFFGDLNNFRAFNNQDLPN
TPPTQAGGGNGNGGNNRRPGGPQQQASQKPNGLLEEFGINLTDIARKGEIDPVIGRDEEITRVIEILNRRTKNNPVLIGE
PGVGKTAVVEGLAQKIVDGDVPQKLHGKNVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRQDVILFIDEIHEIVGAGS
AGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVAETITILKGIQPKYEDYHHVKYTDE
AIEAAANLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDHRLIEAENLKAQATRDEDYEKAAYFRDQIAKYKE
MQSAKLDKENTPVITEKNIEVIVEQKTNIPVGELKEKEQSQLIHLADDLKTRVIGQDAAVDKIAKAIRRNRVGLGTPNRP
IGSFLFVGPTGVGKTELSKQLAIELFGSEDSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILLD
EVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEANVGFGASREGRTNSVLGELGNFFSPEFMNR
FDGIIEFQALSKDNLLQIVSLMLDDVNQRLAVNAIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQEHIEDAITDFYLEH
PEQKELKAIMTSNGKIVIKASNKVETVTKATSD

Nucleotide

• Length: 2262 bp

>NTDB_id=115756 SMUFR_RS02670 WP_002263569.1 525017..527278(-) (clpE) [Streptococcus mutans UA159-FR]
ATGCTCTGTCAAAATTGTAAATTAAATGAAGCGACTATTCATCTATATGCTAATGTTAATGGTCAGCAAAAGCAGATTGA
CCTTTGTCAAAATTGTTATCAAATTATGAAAACAGATCCTGAAAATGGACCTTTAAATCATCTTTCGCAACAAAATTCAT
CATCCATCAATCCTTTCTTTGATGATTTCTTTGGCGATTTGAATAATTTTCGTGCCTTTAATAATCAAGATCTGCCAAAC
ACACCGCCAACACAAGCTGGCGGCGGCAATGGCAACGGAGGCAATAATCGCCGTCCCGGCGGACCTCAGCAACAGGCCTC
CCAAAAGCCAAATGGGTTGCTTGAAGAGTTTGGTATTAATTTAACAGATATTGCGCGCAAGGGTGAAATTGATCCTGTTA
TTGGCCGTGATGAAGAAATCACAAGGGTTATCGAAATTCTCAACCGTCGCACAAAGAATAATCCTGTTCTTATTGGAGAA
CCGGGTGTCGGTAAAACTGCTGTTGTCGAAGGACTGGCGCAAAAAATTGTTGATGGTGATGTTCCACAAAAATTACATGG
AAAAAATGTCATTCGTCTGGACGTCGTCAGCCTTGTTCAAGGTACTGGTATTCGAGGCCAATTTGAAGAACGGATGCAAA
AGCTAATGGAAGAAATCCGTCAACGTCAAGATGTTATTCTTTTCATTGATGAAATTCATGAAATTGTTGGTGCTGGTTCT
GCTGGCGATGGCAATATGGATGCCGGAAATATTTTAAAACCCGCTTTGGCACGCGGTGAGCTTCAACTTGTTGGTGCTAC
AACACTCAATGAATATCGGATTATTGAAAAAGATGCCGCTTTGGAACGTCGAATGCAACCCGTAAAAGTTGATGAACCTA
GTGTTGCAGAAACCATAACGATTCTTAAAGGTATTCAGCCCAAATATGAAGATTACCATCATGTAAAGTATACAGATGAA
GCGATTGAAGCTGCTGCAAATCTTTCAAATCGTTACATTCAGGATCGTTTCTTACCTGATAAGGCTATTGATCTTCTAGA
TGAAGCTGGCTCTAAAATGAATTTAACACTTAACTTTGTAGATCCTAAAGAAATTGATCACCGCTTGATTGAAGCCGAAA
ATCTAAAAGCTCAAGCAACCCGTGATGAGGATTATGAAAAAGCAGCTTACTTCCGTGATCAAATTGCCAAATACAAGGAA
ATGCAATCCGCTAAACTTGATAAGGAGAATACTCCTGTTATTACAGAAAAAAATATTGAAGTAATTGTCGAGCAAAAGAC
CAATATTCCTGTTGGTGAATTAAAAGAAAAGGAACAATCACAATTAATTCATCTCGCTGACGATCTTAAAACGCGTGTTA
TTGGACAGGATGCTGCTGTTGATAAAATTGCTAAAGCTATTCGCCGCAATCGTGTTGGACTAGGCACTCCAAATCGGCCA
ATTGGTTCTTTCCTTTTTGTCGGCCCTACTGGTGTTGGTAAAACGGAACTCTCTAAACAATTAGCCATTGAGCTTTTTGG
TTCTGAAGATAGTATGATTCGTTTCGATATGAGTGAATACATGGAAAAACATGCTGTGGCTAAACTTGTTGGTGCACCTC
CGGGATATGTCGGTTATGAAGAAGCTGGTCAGTTAACCGAAAAAGTTCGTCGCAACCCTTATTCATTGATCTTACTCGAT
GAAGTTGAAAAAGCTCACCCAGATGTCATGCATATGTTCTTACAAGTGCTTGATGATGGTCGTCTAACGGATGGGCAAGG
ACGCACTGTCAGCTTTAAGGATACTATTATTATCATGACCTCAAATGCTGGTACAGGGAAATCTGAAGCTAATGTTGGTT
TTGGTGCCAGTCGAGAAGGCCGTACTAATTCTGTTCTAGGCGAATTGGGTAACTTCTTTAGCCCTGAATTTATGAACCGT
TTTGATGGTATCATCGAATTTCAGGCTTTAAGCAAGGATAATCTTCTTCAAATTGTTTCTCTCATGCTGGATGACGTTAA
TCAACGTTTAGCTGTTAATGCTATTCACCTTGATGTAACTGATAAAGTTAAAGAAAAATTGGTTGATCTCGGTTATGATC
CTAAAATGGGAGCAAGACCGCTGCGTCGTACTATCCAAGAACATATTGAAGATGCTATTACGGATTTCTACTTAGAGCAT
CCTGAACAAAAAGAACTAAAAGCTATTATGACAAGCAATGGCAAAATTGTTATCAAGGCTTCTAACAAAGTCGAGACGGT
TACCAAAGCAACTTCAGATTAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (294-391)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (650-721)

• AAA domain (Cdc48 subfamily) (AAA_2) (479-642)

• ATPase family associated with various cellular activities (AAA) (AAA) (156-275)

3D structure

• AlphaFold DB: Q8DVD0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	100	100	1
clpE	Streptococcus pneumoniae Rx1	82.754	99.336	0.822
clpE	Streptococcus pneumoniae D39	82.754	99.336	0.822
clpE	Streptococcus pneumoniae R6	82.754	99.336	0.822
clpE	Streptococcus pneumoniae TIGR4	82.754	99.336	0.822
clpC	Lactococcus lactis subsp. cremoris KW2	76.424	100	0.766
clpC	Bacillus subtilis subsp. subtilis str. 168	53.313	86.189	0.459
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.846	86.321	0.413
clpC	Streptococcus pneumoniae Rx1	49.355	82.337	0.406
clpC	Streptococcus pneumoniae D39	49.355	82.337	0.406
clpC	Streptococcus pneumoniae TIGR4	49.194	82.337	0.405
clpC	Streptococcus thermophilus LMD-9	47.764	83.134	0.397
clpC	Streptococcus thermophilus LMG 18311	47.444	83.134	0.394
clpC	Streptococcus mutans UA159	47.011	82.205	0.386