Detailed information NTG1150526

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DYY95_RS11185
• Genome accession: NZ_LT996891
• Coordinates: 2192826..2193869 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 24117-WT
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2187826..2198869

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DYY95_RS11145	-	2188193..2188303 (+)	111	WP_001790257.1	hypothetical protein	-
DYY95_RS11150	-	2188332..2188745 (+)	414	WP_001566709.1	hypothetical protein	-
DYY95_RS11160	-	2189235..2190221 (-)	987	WP_000999713.1	FUSC family protein	-
DYY95_RS11170	map	2190752..2191510 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
DYY95_RS11175	-	2191727..2192113 (+)	387	WP_001110179.1	hypothetical protein	-
DYY95_RS11180	liaF	2192128..2192829 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DYY95_RS11185	vraS	2192826..2193869 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DYY95_RS11190	vraR	2193859..2194488 (+)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
DYY95_RS11195	-	2194600..2195817 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
DYY95_RS11200	-	2196095..2196370 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
DYY95_RS11205	-	2196377..2196841 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DYY95_RS11210	-	2196988..2197188 (+)	201	WP_000180460.1	DUF1128 family protein	-
DYY95_RS11215	-	2197191..2198447 (+)	1257	WP_072419726.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1150526 DYY95_RS11185 WP_001017131.1 2192826..2193869(+) (vraS) [Staphylococcus aureus isolate 24117-WT]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1150526 DYY95_RS11185 WP_001017131.1 2192826..2193869(+) (vraS) [Staphylococcus aureus isolate 24117-WT]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGCATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1