Detailed information NTG1150442

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DYY93_RS11185
• Genome accession: NZ_LT996889
• Coordinates: 2192823..2193866 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 24117-REV
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2187823..2198866

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DYY93_RS11145	-	2188190..2188300 (+)	111	WP_001790257.1	hypothetical protein	-
DYY93_RS11150	-	2188329..2188742 (+)	414	WP_001566709.1	hypothetical protein	-
DYY93_RS11160	-	2189232..2190218 (-)	987	WP_000999713.1	FUSC family protein	-
DYY93_RS11170	map	2190749..2191507 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
DYY93_RS11175	-	2191724..2192110 (+)	387	WP_001110179.1	hypothetical protein	-
DYY93_RS11180	liaF	2192125..2192826 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DYY93_RS11185	vraS	2192823..2193866 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DYY93_RS11190	vraR	2193856..2194485 (+)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
DYY93_RS11195	-	2194597..2195814 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
DYY93_RS11200	-	2196092..2196367 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
DYY93_RS11205	-	2196374..2196838 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DYY93_RS11210	-	2196985..2197185 (+)	201	WP_000180460.1	DUF1128 family protein	-
DYY93_RS11215	-	2197188..2198444 (+)	1257	WP_072419726.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1150442 DYY93_RS11185 WP_001017131.1 2192823..2193866(+) (vraS) [Staphylococcus aureus isolate 24117-REV]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1150442 DYY93_RS11185 WP_001017131.1 2192823..2193866(+) (vraS) [Staphylococcus aureus isolate 24117-REV]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGCATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1